Abstract: An aerosol generating device configured to operate with a consumable article includes a heating chamber configured to receive and heat at least a part of the consumable article and an expandable container containing a heat expandable material. The heating chamber includes at least one moveable element. The expandable container is configured to cause, by expansion of the heat expandable material, the moveable element to compress the part of the consumable article when it is received in the heating chamber and when the heating chamber is operated to heat the part of the consumable article.

Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an actuator assembly that is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.

Abstract: A nicotine product, and more particularly a nicotine pouch product container, a method of consuming a nicotine pouch product, and nicotine pouches and an oral product comprised in the nicotine pouch product container are provided. The nicotine pouch product container includes a plurality of nicotine pouches for nicotine oral delivery having a pH ranging from 7.5 to 11; and at least one oral product including a buffer component.

Abstract: Techniques for managing anomalies in a software system include monitoring the software system for anomalies via a plurality of signals and determining that signal results associated with the signals indicate a presence of an anomaly in the software system. The techniques also include identifying a hierarchy of sensors associated with the anomaly, where the hierarchy includes a parent sensor and a set of child sensors that are direct or indirect descendants of the parent sensor. The techniques additionally include executing the parent and child sensors to analyze the software system for one or more causes of the anomaly, and determining the cause(s) of the anomaly based on sensor results generated by the parent and child sensors. Finally, the techniques include causing remediation of the cause(s) of the anomaly based on one or more child sensors associated with the cause(s) and one or more resolutions mapped to the child sensor(s).

Abstract: A lubrication assembly and operating method are provided herein. The lubrication assembly includes a rotating component an axial recess positioned on an axial side of the rotating component, and a lubricant conveyor that remains stationary relative to the rotating component and extends into the axial recess to form a gap between axial recess and the first lubricant conveyor. The lubricant conveyor directs a lubricant toward the axial recess during rotation to generate a lubricant spray focused in a targeted direction.

Abstract: A fluid sump for accommodating a lubricating fluid and transmission housing for a vehicle comprising such a fluid sump. The fluid sump may comprise a first compartment for collecting the lubricating fluid, a second compartment in which the lubricating fluid can be brought in contact with a rotating member, and an intermediate compartment having a first opening for introducing the lubricating fluid from the first compartment into the intermediate compartment, a second opening for introducing the lubricating fluid from the intermediate compartment into the second compartment, and a floating element. In one or more examples, the first opening can be opened and closed by the floating element, and the first compartment, the intermediate compartment and the second compartment are provided with ambient pressure.

Abstract: A system and method for lubrication system are provided. The lubrication system includes a floater container including a floater compartment that contains a buoyant floater, where the floater container is coupled to a housing bulkhead and where the floater container includes an inlet opening in a first wall that is off-axis from a horizontal plane and forms an angle with a second wall. Further, the housing bulkhead includes an outlet opening positioned lower than the inlet opening and provides fluidic communication between the floater compartment and a rotating component compartment that contains a rotating component.

Abstract: A system and method for lubrication system are provided. The lubrication system includes a floater container including a floater compartment that contains a buoyant floater, where the floater container is coupled to a housing bulkhead and where the floater container includes an inlet opening in a first wall that is off-axis from a horizontal plane and forms an angle with a second wall. Further, the housing bulkhead includes an outlet opening positioned lower than the inlet opening and provides fluidic communication between the floater compartment and a rotating component compartment that contains a rotating component.

Abstract: Provided is an electronic equipment offering a plurality of controllable functionalities and that receives information designating a functionality selected amongst this plurality of controllable functionalities. The electronic equipment also receives a plurality of recordings of a same group of at least one user input for this selected functionality. The electronic equipment also applies a trained neural network model on this received plurality of recordings to recognize an input pattern. The electronic equipment also associates this recognized input pattern with this selected functionality, and stores this association in a memory. The electronic equipment also controls this selected functionality based on this stored association.

Abstract: A wet brake system, a method therefor, and a vehicle including such system, the system comprising: a housing enclosing a brake compartment, at least one friction plate rotatably disposed within the brake compartment, at least one separator plate disposed within the brake compartment, coupled to the housing and configured to be frictionally engaged with the at least one friction plate for braking the at least one friction plate, the at least one friction plate and the at least one separator plate configured to be at least partially submersed in a liquid held within the brake compartment, and a liquid reservoir, wherein a drain port is arranged such that the at least one friction plate when rotating is configured to convey liquid held within the brake compartment to the liquid reservoir via the drain port and a drain channel for draining the brake compartment.

Abstract: The present disclosure provides a method of treating or preventing metabolic disorders by administering agents that inhibit the activity of microRNAs that modulate metabolism.

Abstract: The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

Abstract: The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2-breast cancer patients.

Abstract: The present invention relates to methods and kits for the evaluation of risk and treatment of distant recurrence of breast cancer in a subject. The methods and kits can comprise combining the measured expression levels of a subset of genes selected from a 20-gene signature with tumor size and nodal status to determine the risk of distant recurrence.

Abstract: Apparatus (1) for checking the dimensions and/or shape of a complex-shaped body (3), comprising a checking support (5) on which the body to be checked is positioned, a robotic system (8) with an optical assembly (17) and a memory unit (19) for storing reference data relating to a reference shape of the body. A processing and control unit (18) controls movements of the optical assembly so as to obtain dimensional values relating to the body at predetermined measuring points, these dimensional values then being compared with the reference data stored in the memory unit. The apparatus further comprises reference elements (35) defined in the checking support in predetermined positions and a distance sensor (17) for acquiring actual positions of said reference elements. Local compensation parameters for correcting positioning errors of the robotic system are calculated for each of the reference elements on the basis of the predetermined positions and the actual positions acquired.

Abstract: Methods and systems for a transmission are provided. The method includes estimating a stroke position of the hydraulic control piston based on a pressure of a fluid in a hydraulic line and a valve and a coefficient of the hydraulic line, where the hydraulic line is coupled to a chamber of the hydraulic control piston. The method further includes controlling a pressure of fluid delivered from the valve to the hydraulic control piston based on the estimated stroke position to achieve a piston stroke set-point during a filling phase.

Abstract: The invention provides methods, compositions, and kits for characterizing open chromatin by dual DNA/protein tagging.

Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engageable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.

Abstract: Provided is an electronic equipment offering a plurality of controllable functionalities and that receives information designating a functionality selected amongst this plurality of controllable functionalities. The electronic equipment also receives a plurality of recordings of a same group of at least one user input for this selected functionality. The electronic equipment also applies a trained neural network model on this received plurality of recordings to recognize an input pattern. The electronic equipment also associates this recognized input pattern with this selected functionality, and stores this association in a memory. The electronic equipment also controls this selected functionality based on this stored association.

Abstract: The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.