Abstract: An aircraft propulsion system includes a turbomachine and at least one electric motor. The motor includes a first half-motor and a second half-motor that include, respectively, a first stator and a second stator cooperating with a common rotor of the motor. The propulsion system further includes at least one first energy source (B) capable of delivering a DC voltage and at least one electric generator (PMG) driven by the turbomachine. The electric generator generates an AC voltage to form a second energy source and is associated with an active rectifier that transforms the AC voltage into a DC voltage. The value of the DC voltage is controlled by the active rectifier, the output of which is connected to the first energy source.

Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: The invention concerns a method for diagnosing a cancer in a subject, comprising a step of RT-MLPA on a biological sample obtained from the subject, in which the RT-MLPA step is carried out using at least one pair of probes comprising at least one probe chosen among the probes with SEQ ID NO: 1 to 13, and/or the probes with SEQ ID NO: 96 to 99, and/or the probes with SEQ ID NO: 866 to 938, and/or the probes with SEQ ID NO: 940 to 1104, and/or SEQ ID NO: 211 to 1312, and/or the probes with SEQ ID NO: 96 to 99, and/or the probes with SEQ ID NO: 1105 to 1107 and/or the probe with SEQ ID NO: 939 and/or the probes with SEQ ID NO: 1108 to 1123, each of the probes being fused, at at least one end, with a priming sequence, and at least one of the probes of the pair comprising a molecular barcode sequence.

Abstract: The present invention concerns an outboard propulsion device for a navigational seacraft comprising a propulsion means (4), at least one engine (1) supplying torque to a drive shaft (20) extending out of the engine and driving a transmission shaft (3) intended to supply torque to the propulsion means, the drive shaft and the propulsion shaft being in a fixed relative orientation, and a transmission means (2) connected at the input to the drive shaft (20) in order to receive the engine torque and transmit it, in the form of modified torque, to the transmission shaft (3) to which it is connected at the output, and the transmission shaft (3) is a double universal joint shaft (30, 31) that extends in an inclined manner between the transmission means (2) and the propulsion means (4).

Abstract: An aircraft propulsion system includes a turbomachine and at least one electric motor. The motor includes a first half-motor and a second half-motor that include, respectively, a first stator and a second stator cooperating with a common rotor of the motor. The propulsion system further includes at least one first energy source (B) capable of delivering a DC voltage and at least one electric generator (PMG) driven by the turbomachine. The electric generator generates an AC voltage to form a second energy source and is associated with an active rectifier that transforms the AC voltage into a DC voltage. The value of the DC voltage is controlled by the active rectifier, the output of which is connected to the first energy source.

Abstract: The present invention concerns an outboard propulsion device for a navigational seacraft comprising a propulsion means (4), at least one engine (1) supplying torque to a drive shaft (20) extending out of the engine and driving a transmission shaft (3) intended to supply torque to the propulsion means, the drive shaft and the propulsion shaft being in a fixed relative orientation, and a transmission means (2) connected at the input to the drive shaft (20) in order to receive the engine torque and transmit it at least partially to the transmission shaft.

Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Circuitry comprises a translation lookaside buffer to store data representing memory address translations, each memory address translation being between an input memory address range defining a contiguous range of one or more input memory addresses in an input memory address space and a translated output memory address range defining a contiguous range of one or more output memory addresses in an output memory address space; in which the translation lookaside buffer comprises a plurality of memory elements to store one or more arrays each having a base input memory address, a base output memory address and a plurality of entries each mapping an n-bit offset to an m-bit offset, each entry representing a memory address translation of an input memory address range defined by the respective n-bit offset relative to the base input memory address to a translated output memory address range defined by the respective m-bit offset relative to the base output memory address; in which n and m are positive integers and n

Abstract: An internal combustion engine having at least one crankcase for defining a guide housing in which at least one crankshaft is guided in rotation about an axis of rotation and lubricated by a lubricating fluid, the at least one crankcase being of the “dry-sump” type. Such an internal combustion engine has at least two pumps forming a pump train of pumps on a common axis, the pump train being fitted in a cylindrical bore of the at least one crankcase.

Abstract: Provided herein are synthetic analogs of withanolide natural products and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: A cylinder head, an element and a base plate of a longitudinal piston engine having a cylinder head body and a base plate comprising at least one element, the base plate being interposed between a combustion chamber and the cylinder head body, comprising an upper face facing the cylinder head body and an opposing lower face arranged to face the combustion chamber and being attached to the cylinder head body, the cylinder head body being made from a material with a mass density and hardness that are less than those of the material constituting the base plate. The base plate and the body are assembled by screws for fastening the base plate to the cylinder head that are located towards the periphery of the base plate and of the body and by at least one part for fastening the cylinder head to the base plate including a threaded end designed to be engaged in a corresponding orifice of the base plate, said orifice being located closer to the center of the base plate than the fastening screws.

Abstract: Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.

Abstract: Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-?B in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.

Abstract: The present invention relates to a combustion engine which includes at least one crankshaft rotating about a first rotation shaft; at least one output shaft outputting an engine torque, said output shaft rotating about a second rotation shaft separate from said first rotation shaft; at least one transmission assembly rotating about said first rotation shaft and being rotated by said crankshaft in order to transmit said engine torque to said output shaft.

Abstract: The present invention provides methods and uses for the diagnostic of a subject predisposed or suspected of developing a neurodegenerative disease or suffering from a neurodegenerative disease. The present invention also relates to methods and uses for identifying candidate compounds and to compounds for treating neurodegenerative disease. The present invention also relates to an animal model for neurodegenerative disease.

Abstract: The present invention relates to a combustion engine which includes at least one crankshaft rotating about a first rotation shaft; at least one output shaft outputting an engine torque, said output shaft rotating about a second rotation shaft separate from said first rotation shaft; at least one transmission assembly rotating about said first rotation shaft and being rotated by said crankshaft in order to transmit said engine torque to said output shaft.

Abstract: A plant detection device is provided that includes a robotic arm having gripping element that includes first and second curved grippers with opposing concave surfaces that move between an open and closed states, and the arm moves and vibrates the gripping element, a proximity force sensor that is disposed on the gripper and outputs a measurement signal of a force between the gripping element and an outgrowth from a stem of a plant under test to a computer, a force and frequency sensor that is orthogonal to the proximity force sensor outputs a gripping force measurement and a frequency response measurement of the stem of the plant under test to the computer, where the computer moves the gripping and vibrating arm according to the sensor signal outputs.

Abstract: An internal combustion engine having at least one crankcase for defining a guide housing in which at least one crankshaft is guided in rotation about an axis of rotation and lubricated by a lubricating fluid, the at least one crankcase being of the “dry-sump” type. Such an internal combustion engine has at least two pumps forming a pump train of pumps on a common axis, the pump train being fitted in a cylindrical bore of the at least one crankcase.