Abstract: The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of metastases. The inventors showed in vivo that lung metastasis in GPVI deficient mice are reduced compared to controls. They demonstrated that GPVI is involved in platetet interaction with tumor cells and this interaction is mediated by EMMPRIN.). Using an anti-EMMPRIN antibody, they showed that the adhesion of platelets to tumors cells is decreased. In particular, the present invention relates to a method for the prophylactic treatment of metastases in a patient suffering from cancer comprising administering to the subject a therapeutically effective amount of an agent which inhibits the interaction between GPVI and EMMPRIN.

Abstract: The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of metastases. The inventors showed in vivo that lung metastasis in GPVI deficient mice are reduced compared to controls. They demonstrated that GPVI is involved in platetet interaction with tumor cells and this interaction is mediated by EMMPRIN.). Using an anti-EMMPRIN antibody, they showed that the adhesion of platelets to tumors cells is decreased. In particular, the present invention relates to a method for the prophylactic treatment of metastases in a patient suffering from cancer comprising administering to the subject a therapeutically effective amount of an agent which inhibits the interaction between GPVI and EMMPRIN.

Abstract: The present invention relates to processes and apparatus useful for the production of polymer powder, and in particular to processes and apparatus for the degassing of polymer powder.

Abstract: Polymerization unit for producing polymer powder having at least one polymerization reactor for the polymerization of light (co)monomer(s) having less than 7 carbon atoms, and heavy comonomer(s) having at least 7 carbon atoms, and a degassing section including two (and optionally a third) cylindrical degassing vessels in series. Light (co)monomer(s) are degassed in the first degassing vessel (V1) and recovered, and heavy comonomers are degassed in the second degassing vessel (V2) and recovered. The active polymer powder is optionally polished and/or optionally deactivated in the optional third degassing vessel (V3). The cross-sectional area (S2) of the second degassing vessel is greater than 1.5 times the cross-sectional area (S1) of the first degassing vessel [S2>1.5×S1], and vessels V1 and V2 are equipped with a vent recovery unit (VR) for respectively recovering the light (co-)monomer(s) (VR1) and the heavy comonomer(s) (VR2) from the gases exiting the vessels.

Abstract: The present invention relates to processes and apparatus useful for the production of polymer powder, and in particular to processes and apparatus for the degassing of polymer powder.

Abstract: The present invention relates to a chromium catalyzed ethylene copolymer powder exhibiting a superior fragmentation coefficient.

Abstract: The present invention relates to a chromium catalysed ethylene copolymer powder exhibiting a superior fragmentation coefficient.

Abstract: The invention concerns elastomeric copolymers of ethylene and propylene wherein the proportion by weight of units derived from ethylene is from 34 to 67% and the proportion by weight of units derived from propylene is from 33 to 66%. The copolymers are characterized in that 60% at least of the units derived from propylene are disposed in sequences of at least three successive units and that their fusion enthalpy, as measured after a given heat treatment, is lower than 15 cal/g (calories per gram) and in most cases is from 5 to 10 cal/g. The copolymers of the invention can be used in particular for the production of isotactic polypropylene compositions.

Abstract: The invention concerns a process for the production of copolymers of propylene and but-1-ene which can be used for the production of hollow bodies or heat-sealable films and wherein the proportion by weight of units derived from but-1-ene is from 10 to 40% and wherein the proportion of isolated ethyl branches is at least equal to the square of the proportion of units derived from propylene contained in said polymers. The process is characterized in that a gaseous mixture of propylene and but-1-ene is brought into contact, in the absence of liquid diluent, with a catalytic system which is stereospecific in the polymerization of propylene alone.

Abstract: The invention concerns a process for the production of elastomeric terpolymers of ethylene, propylene and dienes by the direct polymerization of the monomeric olefins in the gaseous state, in contact with a catalytic system comprising one or more solid compounds of titanium. The resulting terpolymers which are produced in the form of powders can be used without intermediate transformation for the production of molded or extruded articles.

Abstract: A method for the polymerization of olefins using a catalyst in the form of a solid compound of a transition metal in which the transition metal is at least partially reduced to a valency state lower than the maximum valency state, with the transition metal compound being subjected prior to use to pre-activation by contact with magnesium and one or more halogenated hydrocarbons and one or more organo-metallic compounds of Groups II and III.

Abstract: The method of polymerizing olefins which includes the preparation of a pre-activated compound of a transition metal of IVa, Va and VIa of the periodic table of elements, in which the transition metal is at least partially in a reduced valency state, in which the pre-activation is carried out by contacting the transition metal compound with an organomagnesium compound and then polymerizing the olefins in the presence of the pre-activated transition metal compound and an organo-aluminum compound.

Abstract: Atactic waxes and method for preparing same by polymerization of polyolefin alone or in combination with other monoolefins of the formula CH.sub.2 = CHR in which R is hydrogen or an alkyl radical having from 2 to 8 carbon atoms in which the polymerization is carried out at low pressure and in a hydrocarbon solvent in the presence of a catalyst formed of the product of the reaction of magnesium or a compound thereof, a compound of a transition metal selected from the sub-groups IVa, Va and VIa of the periodic classification of elements and an alkyl halide, and a co-catalyst in the form of an organometallic compound of a metal selected of groups II and III of the periodic classification of elements.