Abstract: The present application relates to a fixed dose combination comprising lacosamide and levetiracetam, as well as to dosage regimens including such fixed dose combinations. The fixed dose combinations are suitable for the oral or parenteral treatment of various diseases, including in particular epilepsy and/or epileptic seizures.

Abstract: The present invention provides a pulse detonation insert that induces flow obstructions within the pulse detonation chambers, wherein the flow obstructions are operable to induce turbulence within a primary fluid flow passing over the obstructions. This turbulence may take the form of vortices that enhance the mixing of the oxidizer and fuel within the primary flow. Additionally, supports couple to the pulse detonation chamber walls and flow obstructions to hold the flow obstructions in place within the pulse detonation chamber. The combustion/Detonation of the mixed oxidizing fuel results in an increased velocity of the primary flow exiting the pulse detonation chamber and reduced the amount of unburnt fuel within the exhaust.

Abstract: A turbine disk assembly including a rotatable cylindrical member rotatably coupled to a shaft and a plurality of turbine blades extend circumferentially outward from said cylindrical member. The turbine blades include at least two different geometrical shapes, a first of the geometrical shapes is configured to facilitate extracting power from a first pulsed detonation combustor product stream. A second of said geometrical shapes is configured to facilitate extracting power from a second pulsed detonation combustor product stream that is different from the first pulsed detonation combustor product stream.

Abstract: A detonation chamber for a pulse detonation combustor including: a plurality of dimples disposed on at least a portion of an inner surface of the detonation chamber wherein the plurality of dimples enhance a turbulence of a fluid flow through the detonation chamber

Abstract: A pulse detonation device for dividing a pulse detonation shock wave into an primary and control portion to reduce the strength of a propagating shock wave and/or change its direction. The device contains a flow separator which directs a portion of the shock wave into itself, thus reducing the shock wave's strength. In one configuration, the control region converges in cross-sectional area so as to accelerate the flow in the control region, while the primary region diverges to slow the flow in the primary region. The flow in the control region is directed, at an angle, into the flow of the primary region to impede and/or redirect the flow of the primary region.

Abstract: A pulse detonation (PD) assembly includes at least one PD chamber having a wall, which defines cooling holes arranged along at least a portion of the PD chamber. A manifold extends around the PD chamber. The manifold and PD chamber are separated by a bypass region. A PD assembly with reverse flow cooling includes at least one PD chamber. A sleeve extends around the PD chamber. The sleeve and PD chamber are separated by a reverse flow cooling passage configured to receive a flow of air and to flow the air in a reverse direction to supply the PD chamber. A PD assembly with bypass flow cooling includes at least one PD chamber and a manifold extending around the PD chamber(s), which are separated by a bypass region. The PD assembly further includes a mixing plenum configured to receive and mix the bypass flow from the bypass region and the detonation by-products from the PD chamber(s).

Abstract: The present invention provides a pulse detonation insert that induces flow obstructions within the pulse detonation chambers, wherein the flow obstructions are operable to induce turbulence within a primary fluid flow passing over the obstructions. This turbulence may take the form of vortices that enhance the mixing of the oxidizer and fuel within the primary flow. Additionally, supports couple to the pulse detonation chamber walls and flow obstructions to hold the flow obstructions in place within the pulse detonation chamber. The combustion/Detonation of the mixed oxidizing fuel results in an increased velocity of the primary flow exiting the pulse detonation chamber and reduced the amount of unburnt fuel within the exhaust.