Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to receive a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.

Abstract: The eye sampling device (10) comprises supporting means (12) comprising a sampling surface (11), the supporting means being elastically deformable between a rest position and a sampling position and conformed so that, upon being used for sampling, the sampling surface applied in the sampling position in a coinciding way onto a sampling area (2), is detached therefrom according to a peeling movement when passing from the sampling position to a rest position.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.

Abstract: The invention relates to a device for packaging and dispensing a generally liquid or viscous product, including a container for containing the product to be packaged and dispensed in the form of clean or sterile calibrated doses or drops using a dispensing accessory including a tip, wherein the assembly of the container and the accessory includes an additional flexible and deformable chamber actuated simultaneously with the accessory and capable of either sucking the residual drop at the end of said accessory after dispensing a calibrated dose or drop, or of blowing said calibrated dose or drop without permitting the formation of a residual drop. The invention can be used for packaging and dispensing clean or sterile products, in particular doses or drops in the field of ophthalmology.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: An animal-machine audio interaction system includes a sound monitor for monitoring the sounds made by one or more animals, a sound segmenter for identifying coherent sound segments within the sounds made by the animal(s), a sound analyzer for analyzing and assigning a category to each sound segment, an output sound selector for selecting an output sound appropriate to the category assigned by the sound analyzer, and a sound output unit for outputting the selected output sound to the animal(s). A different control protocol may be used to define the categories assigned to the animal sounds and to determine the respective audio responses that are appropriate to the different sound categories. During operation of the system, a closed-loop audio interaction is set up between the animal(s) and the system. This interaction may be used for various purposes, such as investigating animal behaviour, entertaining the animal(s) and controlling animal behaviour.

Abstract: A new type of Markovian sequence generator and generation method generates a Markovian sequence having controllable properties, notably properties that satisfy at least one control criterion which is a computable requirement holding on items in the sequence. The Markovian sequence is generated chunkwise, each chunk containing a plurality of items in the sequence. During generation of each chunk a search is performed in the space of Markovian sequences to find a chunk-sized series of items which enables the control criterion to be satisfied. The search can be performed using a generate and test approach in which chunk-sized Markovian sequences are generated then tested for compliance with the requirement(s) of the control criteria.

Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: A system and method is provided for generating a multi-dimensional contextual platform that may be used to manage, diagnose, and communicate with patients in a medical practice. In particular, the system may provide a website that may provide dynamic, avatar-based interfaces that include a doctor interface and a patient interface. A doctor may create a subscription with an operator of the website in order to find new patients and view patient health records across multiple dimensions. A patient may create a subscription with the operator to locate a doctor and maintain open communications with the doctor. Once subscribed, the doctor and patient may use the website to enhance the overall healthcare experience by using social networking aspects of the website to facilitate doctor and patient communication in real-time.

Abstract: The feed connector (270) capable of interacting with a device for delivering active principles comprising a reservoir delimited by at least two lateral walls of substantially cylindrical shape and extending opposite one another, is characterized in that it includes means (202, 203, 204, 205) for dispensing active principles into the reservoir that are arranged such that said reservoir is filled substantially uniformly between the two lateral walls.

Abstract: A set of temporal phases are defined, occurring successively during the playback of music (or other content) to a user. Each temporal phase is associated with a set of selection criteria. If the user operates a selection device (which can be a computer mouse button) while a piece of music or other content is being played back, the selection phase applicable at the time of user-action is determined and further content is selected based on the selection criteria associated with the applicable phase. This enables the user, with minimal action, to influence the content being rendered. The selection criteria can be related to the meta-data of the content being played back at the time of user action. The meaning attributed to the applicable temporal phase can be varied depending on the pressure of the mouse button click.

Abstract: Meta-data (tags) for an audiovisual file can be generated by prompting a user to input certain tags (meta-data) descriptive of the audiovisual file, to serve as an initial estimate of the tags, and then revising the initial estimate (notably to expand it and/or render it more precise) based on the assumption that the relationships which hold between the different tags for a set of manually-tagged training examples will also hold for the tags of the input file now being tagged.

Abstract: The invention concerns a device for ocular delivery of an active principle by peroperative intraocular iontophoresis or electroporation comprising a reservoir (7) for receiving a solution comprising the active principle, means for diffusing (8, 6) the active principle connected to the reservoir, means for injecting (4) the solution into the reservoir, and means (5) for exerting suction of the content of the reservoir during an injection of the solution therein by the injection means.

Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.

Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.

Abstract: The invention relates to a connector assembly (10) for the transfer of fluids, particularly fluids comprising an active agent from a reservoir to a medical device for dosage, comprising: a first connector element (20), pertaining to the reservoir with first fixing means (23), a second connector element (10), pertaining to the medical dosage device with second fixing means (12), cooperating with the first fixing means to give an irreversible connection between the two elements. The first and second elements are embodied such as to cooperate with other by clipping on a single translational movement of a connector element relative to the other to produce the irreversible connection, characterized in that at least one of the connection elements is embodied with means to render the same breakable.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.