Patents by Inventor Pierre Trepagnier
Pierre Trepagnier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20120053429Abstract: A non-invasive analyte monitoring instrument has a radiation source for directing excitation radiation to a portion of a surface of a tissue wherein said source emits radiation at a plurality of different wavelengths that excites a target in said tissue causing said target to emit radiation such that the radiation received at the surface provides an analyte level indication of the patient. A radiation detector positioned to receive radiation emitted from the surface wherein said radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation.Type: ApplicationFiled: February 28, 2011Publication date: March 1, 2012Inventors: Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael J. Hopmeier, Nikiforos Kollias
-
Patent number: 7899518Abstract: Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.Type: GrantFiled: September 12, 2005Date of Patent: March 1, 2011Assignee: Masimo Laboratories, Inc.Inventors: Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael J. Hopmeier, Nikiforos Kollias
-
Publication number: 20060283845Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: ApplicationFiled: May 24, 2006Publication date: December 21, 2006Inventors: William Lauer, Pierre Trepagnier, Donald Smart, James Cordingley, Michael Plotkin
-
Publication number: 20060195022Abstract: Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.Type: ApplicationFiled: September 12, 2005Publication date: August 31, 2006Inventors: Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael Hopmeier, Nikiforos Kollias
-
Publication number: 20050211682Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: ApplicationFiled: May 17, 2005Publication date: September 29, 2005Inventors: William Lauer, Pierre Trepagnier, Donald Smart, James Cordingley, Michael Plotkin
-
Patent number: 6911622Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: GrantFiled: May 5, 2003Date of Patent: June 28, 2005Assignee: General Scanning, Inc.Inventors: William Lauer, Pierre Trepagnier, Donald Victor Smart, James Cordingley, Michael Plotkin
-
Patent number: 6721582Abstract: Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.Type: GrantFiled: February 20, 2001Date of Patent: April 13, 2004Assignee: Argose, Inc.Inventors: Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael J. Hopmeier, Nikiforos Kollias
-
Patent number: 6639668Abstract: The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention is useful for biomedical diagnostics, chemical analysis or other evaluation of the target sample.Type: GrantFiled: November 3, 2000Date of Patent: October 28, 2003Assignee: Argose, Inc.Inventor: Pierre Trepagnier
-
Publication number: 20030195401Abstract: An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.Type: ApplicationFiled: May 22, 2003Publication date: October 16, 2003Inventors: Wei Dong Tian, Pierre Trepagnier
-
Publication number: 20030189032Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: ApplicationFiled: May 5, 2003Publication date: October 9, 2003Applicant: General Scanning, a Massachusetts corporationInventors: William Lauer, Pierre Trepagnier, Donald Victor Smart, James Cordingley, Michael Plotkin
-
Patent number: 6597932Abstract: An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.Type: GrantFiled: February 20, 2001Date of Patent: July 22, 2003Assignee: Argose, Inc.Inventors: Wei Dong Tian, Pierre Trepagnier
-
Patent number: 6559412Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: GrantFiled: October 2, 2001Date of Patent: May 6, 2003Inventors: William Lauer, Pierre Trepagnier, Donald Victor Smart, James Cordingley, Michael Plotkin
-
Publication number: 20020133080Abstract: The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device of the invention comprises at least one scattering layer, which is preferably non-fluorescent, and a second layer containing one or more fluorophore. Light passes through the scattering layer and excites the fluorophore. Light emitted from the fluorophore passes back though the scattering layer and into collecting optics, which can be measured and that measurement used to correct for instrument drift.Type: ApplicationFiled: February 6, 2002Publication date: September 19, 2002Inventors: William Apruzzese, Pierre Trepagnier, Russell Gray, James Mansfield, Christopher Lambert
-
Publication number: 20020058864Abstract: The invention relates to devices and methods that improve the quality of optic measurements from surfaces such as skin and biological materials. Three methods for reducing spectral site to site variation in fluorescence and/or reflectance signals obtained from a sample surface are: repeated measurements taken at identifiable location(s) determined by fiducial marks, repeat of measurements at different locations on the sample, and tensioning the sample surface during measurement to alleviate surface heterogeneity. Combinations of these methodologies provide best results, and are expected to improve the ability to measure blood glucose non-invasively.Type: ApplicationFiled: November 13, 2001Publication date: May 16, 2002Inventors: James R. Mansfield, Robert G. Messerschmidt, Solomon Marini, Pierre Trepagnier
-
Publication number: 20020017510Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: ApplicationFiled: October 2, 2001Publication date: February 14, 2002Inventors: William Lauer, Pierre Trepagnier, Donald Victor Smart, James Cordingley, Michael Plotkin
-
Publication number: 20020016534Abstract: Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.Type: ApplicationFiled: February 20, 2001Publication date: February 7, 2002Inventors: Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael J. Hopmeier, Nikiforos Kollias
-
Publication number: 20020010401Abstract: This invention relates to a method for quantitating the relationship between an analyte level in in vivo tissue and the auto-fluorescent spectral characteristics in the tissue.Type: ApplicationFiled: May 16, 2001Publication date: January 24, 2002Inventors: Andrew Bushmakin, James R. Mansfield, Pierre Trepagnier
-
Publication number: 20010039483Abstract: This invention relates to the reduction of inter-subject variation via transfer standardization. According to the method, the effects of inter-subject variation on the analysis of spectra collected from the skin of two or more different subjects is reduced by correcting for the differences between spectra collected from said two or more subjects.Type: ApplicationFiled: February 20, 2001Publication date: November 8, 2001Inventors: Derek Brand, Jenny Freeman, James Mansfield, Pierre Trepagnier
-
Patent number: 6300590Abstract: The invention provides a system and method for vaporizing a target structure on a substrate. According to the invention, a calculation is performed, as a function of wavelength, of an incident beam energy necessary to deposit unit energy in the target structure. Then, for the incident beam energy, the energy expected to be deposited in the substrate as a function of wavelength is calculated. A wavelength is identified that corresponds to a relatively low value of the energy expected to be deposited in the substrate, the low value being substantially less than a value of the energy expected to be deposited in the substrate at a higher wavelength. A laser system is provided configured to produce a laser output at the wavelength corresponding to the relatively low value of the energy expected to be deposited in the substrate.Type: GrantFiled: December 16, 1998Date of Patent: October 9, 2001Assignee: General Scanning, Inc.Inventors: William Lauer, Pierre Trepagnier, Donald Victor Smart, James Cordingley, Michael Plotkin
-
Patent number: 5400132Abstract: Methods of compensating for errors in a laser pointing device, particularly for use in three-dimensional applications, by accurately controlling the angle that the laser beam makes in space.A method for rectifying a laser pointing device that aims a laser beam by deflecting the beam through a plurality of optical deflection devices each directed by a galvanometer controlled by an input. In the method, the laser pointing device is established in an accurate angular relationship to at least four fiducial points. The angular errors internal of the laser pointing device are determined by comparing actual galvanometer inputs to nominal galvanometer inputs, assuming no error in the established angular relationship. The actual galvanometer inputs are those that aim the laser beam at the fiducial points (while recognizing the existence of the internal errors), and the nominal galvanometer inputs are those that would aim the laser beam at the fiducial points assuming no internal errors in the laser pointing device.Type: GrantFiled: October 12, 1993Date of Patent: March 21, 1995Assignee: General ScanningInventor: Pierre Trepagnier