Patents by Inventor Pietro Bollinger
Pietro Bollinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8258128Abstract: The present invention relates to novel aza-thia-benzoazulene derivatives of formula I as defined in the claims, their preparation, the use of these novel compounds for the preparation of pharmaceutical compositions, the use of these novel compounds and compositions for managing arthritis and arthritis-related conditions as well as in the treatment of pain in animals and humans. More particularly, the present invention relates to pharmaceutical, preferably veterinary compositions and methods for reducing inflammation and pain associated with acute inflammation of body parts, particularly joints, due to injury or due to arthritic conditions or other disease conditions.Type: GrantFiled: February 21, 2007Date of Patent: September 4, 2012Assignee: Novartis AGInventors: Pietro Bollinger, Mahavir Prashad, Bernhard Riss, Janet Dawson King, Peter C. Hiestand, Yugang Liu, Jonathan King, Vincent Schmid, Friedrich Schuerch
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Publication number: 20090131408Abstract: The present invention relates to novel aza-thia-benzoazulene derivatives of formula I as defined in the claims, their preparation, the use of these novel compounds for the preparation of pharmaceutical compositions, the use of these novel compounds and compositions for managing arthritis and arthritis-related conditions as well as in the treatment of pain in animals and humans. More particularly, the present invention relates to pharmaceutical, preferably veterinary compositions and methods for reducing inflammation and pain associated with acute inflammation of body parts, particularly joints, due to injury or due to arthritic conditions or other disease conditions.Type: ApplicationFiled: February 21, 2007Publication date: May 21, 2009Inventors: Pietro Bollinger, Mahavir Prashad, Bernhard Riss, Janet Dawson King, Peter C. Hiestand, Yugang Liu, Jonathan King, Vincent Schmid, Friedrich Schuerch
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Patent number: 6255100Abstract: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.Type: GrantFiled: September 9, 1999Date of Patent: July 3, 2001Assignee: Novartis AGInventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, RenéP. Traber, Roland Wenger, Pietro Bollinger
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Patent number: 5981479Abstract: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.Type: GrantFiled: May 26, 1998Date of Patent: November 9, 1999Assignee: Novartis AGInventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
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Patent number: 5767069Abstract: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, ?MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.Type: GrantFiled: April 24, 1995Date of Patent: June 16, 1998Assignee: Novartis AGInventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
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Patent number: 5525590Abstract: Cyclosporins wherein the residue at the 1-position (typically -MeBmt- or -dihydro-MeBmt-) is 3'O-acylated or 3'-oxo or -C.sub.1-4 alkoxyimino substituted, or wherein the residue at the 2-position is .beta.-O-acyl or .beta.-oxo substituted, or wherein the residue at the 2-position is -Ile-, or wherein the residue at the 11-position is -MeAls-, -MeIle- or -MealloIle- as well as various naturally occurring cyclosporins/dihydro-derivatives thereof, are useful in reversing resistance to chemotherapy, in particular resistance to cytostatic or anti-neoplastic therapy. Various of these cyclosporins and intermediates for their production are novel. Intermediates wherein the residue (e.g. -MeBmt-, -dihydro-MeBmt- etc.) at the 1-position is 8'-alkoxy or 7'-desmethyl-7'-hydrocarbyl substituted are novel and useful as immunosuppressants, anti-inflammatory and anti-parasitic agents.Type: GrantFiled: November 10, 1994Date of Patent: June 11, 1996Assignee: Sandoz Ltd.Inventors: Pietro Bollinger, Johann J. Bolsterli, Trevor G. Payne
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Patent number: 5096921Abstract: .alpha.-[10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]-carboxyli c acids, or physiologically-hydrolysable and -acceptable esters or pharmaceutically acceptable salts thereof are useful for effecting monokine inhibition, in particular interleukin-1 release or secretion inhibition, as a therapeutic means other than anti-inflammatory or anti-pyretic means.Type: GrantFiled: August 2, 1990Date of Patent: March 17, 1992Assignee: Sandoz Ltd.Inventors: Pietro Bollinger, Hans U. Gubler, Jorg Schnyder
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Patent number: 4956381Abstract: .alpha.-[10-oxy-4H-benzo[4,5]cycloheptal[1,2-b]thiophen-4-ylidene]-carboxyl ic acids, or physiologically-hydrolysable and -acceptable esters or pharmaceutically acceptable salts thereof are useful for effecting monokine inhibition, in particular interleukin-1 release or secretion inhibition, as a therapeutic means other than anti-inflammatory or anti-pyretic means.Type: GrantFiled: October 25, 1988Date of Patent: September 11, 1990Assignee: Sandoz Ltd.Inventors: Pietro Bollinger, Hans U. Gubler, Jorg Schnyder
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Patent number: 4740518Abstract: .alpha.-[5H-dibenzo[a,d]cyclohepten-5-ylidene]-carboxylic acids e.g. of formula I ##STR1## wherein R.sub.1 is H, C.sub.1-4 alkyl or phenyl-(C.sub.1-4 alkyl), R.sub.2 is H or C.sub.1-4 alkyl and ring A is unsubstituted or halo- or hydroxy-substituted, as well as the physiologically-hydrolysable and -acceptable esters thereof have valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic properties.Type: GrantFiled: July 14, 1987Date of Patent: April 26, 1988Assignee: Sandoz Ltd.Inventor: Pietro Bollinger
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Patent number: 4384996Abstract: Novel cyclosporins having an -Allylgly- residue in the 2-position and/or a -(D)-Ser- residue in the 8-position and process for their production. The novel cyclosporins are useful as pharmaceuticals, e.g. as immunosuppressive and anti-inflammatory agents.Type: GrantFiled: January 6, 1982Date of Patent: May 24, 1983Assignee: Sandoz Ltd.Inventors: Pietro Bollinger, Johann J. Bolsterli, Hans Kobel
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Patent number: 4273784Abstract: The present invention concerns prostaglandins having a cyclopropane ring in the 2,3 position.Type: GrantFiled: March 28, 1979Date of Patent: June 16, 1981Assignee: Sandoz Ltd.Inventor: Pietro Bollinger