Patents by Inventor Po-Shun Lee

Po-Shun Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANUCLEATED CELLS FOR THE TREATMENT OF DISEASES
    Publication number: 20210299181
    Abstract: The present disclosure takes advantage of non-naturally existing, novel, anucleated platelets or platelet-like cells or platelet variants (collectively referred to as PLCs) or derivatives thereof (i.e., genetically engineered), which share at least one common receptor, ligand or an antigen with endogenous cells that are targets for autoantibodies and effectuate their clearance. The present disclosure also takes advantage of viral adhesion or entry receptors or genetically engineered PLCs or derivatives thereof, which are engineered to express viral adhesion or entry receptors, that specifically binds to viral proteins on viruses or viral particles and effectuate their clearance.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Inventors: Sunita R. Hett, Karen Weisinger, Yang Peng, Kyle P. McLaughlin, Christian G. Peters, Andrew R. Zukauskas, Brenden W. Smith, Silvia Giannini, Po-Shun Lee
  • METHODS OF IDENTIFYING CFTR MODULATORS
    Publication number: 20190154661
    Abstract: The present disclosure is directed to methods of identifying CFTR modulators using non-mutant or mutant CFTR expressing cells in the presence of a CFTR amplifier compound.
    Type: Application
    Filed: May 9, 2017
    Publication date: May 23, 2019
    Inventors: John Miller, Lawrence J. Drew, II, Po-Shun Lee
  • Diagnostic and therapeutic uses of gelsolin in renal failure
    Patent number: 10272136
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: April 30, 2019
    Assignees: The General Hospital Corporation, The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ravi Thadhani, Thomas P. Stossel, Po-Shun Lee, Ananth Karumanchi
  • TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS
    Publication number: 20190091220
    Abstract: The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising administering to a subject having the cancer a pharmaceutically-effective amount of a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. In some embodiments, the condition associated with mTORC1 hyperactivation is tuberous sclerosis complex (TSC). In some embodiments, the condition associated with mTORC1 hyperactivation is lymphangioleiomyomatosis (LAM). In some embodiments, the condition associated with mTORC1 hyperactivation is TSC2-deficient cancer.
    Type: Application
    Filed: April 26, 2018
    Publication date: March 28, 2019
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Po-Shun LEE, Jane YU, Yang SUN
  • METHODS OF TREATING PULMONARY DISEASES AND DISORDERS
    Publication number: 20190022071
    Abstract: The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.
    Type: Application
    Filed: August 31, 2016
    Publication date: January 24, 2019
    Inventor: Po-Shun Lee
  • Use of gelsolin to treat infections
    Patent number: 10022424
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: July 17, 2018
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Po-Shun Lee
  • Targeting PARP1 for treatment of TSC and cancers
    Patent number: 9987275
    Abstract: The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising administering to a subject having the cancer a pharmaceutically-effective amount of a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. In some embodiments, the condition associated with mTORC1 hyperactivation is tuberous sclerosis complex (TSC). In some embodiments, the condition associated with mTORC1 hyperactivation is lymphangioleiomyomatosis (LAM). In some embodiments, the condition associated with mTORC1 hyperactivation is TSC2-deficient cancer.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: June 5, 2018
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Po-Shun Lee, Jane Yu, Yang Sun
  • DIAGNOSTIC AND THERAPEUTIC USES OF GELSOLIN IN RENAL FAILURE
    Publication number: 20170189483
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Application
    Filed: January 17, 2017
    Publication date: July 6, 2017
    Inventors: RAVI THADHANI, THOMAS P. STOSSEL, PO-SHUN LEE, ANANTH KARUMANCHI
  • TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS
    Publication number: 20170049771
    Abstract: The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising administering to a subject having the cancer a pharmaceutically-effective amount of a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. In some embodiments, the condition associated with mTORC1 hyperactivation is tuberous sclerosis complex (TSC). In some embodiments, the condition associated with mTORC1 hyperactivation is lymphangioleiomyomatosis (LAM). In some embodiments, the condition associated with mTORC1 hyperactivation is TSC2-deficient cancer.
    Type: Application
    Filed: April 23, 2015
    Publication date: February 23, 2017
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Po-Shun LEE, Jane YU, Yang SUN
  • Diagnostic and therapeutic uses of gelsolin in renal failure
    Patent number: 9575072
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: February 21, 2017
    Assignees: The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Ravi Thadhani, Thomas P. Stossel, Po-Shun Lee, Ananth Karumanchi
  • USE OF GELSOLIN TO TREAT MULTIPLE SCLEROSIS AND TO DIAGNOSE NEUROLOGIC DISEASES
    Publication number: 20130230455
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Application
    Filed: April 12, 2013
    Publication date: September 5, 2013
    Applicants: BloodCenter Research Foundation, Inc., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • Use of gelsolin to treat multiple sclerosis and to diagnose neurologic disease (stossel)
    Patent number: 8440622
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: May 14, 2013
    Assignees: The Brigham and Women's Hospital, Inc., BloodCenter Research Foundation, Inc.
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • Use Of Gelsolin To Treat Multiple Sclerosis And To Diagnose Neurologic Disease (Stossel)
    Publication number: 20100021428
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Application
    Filed: March 14, 2007
    Publication date: January 28, 2010
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • DIAGNOSTIC AND THERAPEUTIC USES OF GELSOLIN IN RENAL FAILURE
    Publication number: 20090258830
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Application
    Filed: January 23, 2009
    Publication date: October 15, 2009
    Inventors: Ravi Thadhani, Thomas P. Stossel, Po-Shun Lee, Ananth Karumanchi
  • USE OF GELSOLIN TO TREAT INFECTIONS
    Publication number: 20080261260
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: January 23, 2008
    Publication date: October 23, 2008
    Inventors: Thomas P. Stossel, Po-Shun Lee
  • USE OF GELSOLIN TO TREAT INFECTIONS
    Publication number: 20080125370
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: February 6, 2008
    Publication date: May 29, 2008
    Inventors: Thomas P. Stossel, Po-Shun Lee
  • USE OF GELSOLIN TO TREAT INFECTIONS
    Publication number: 20080118945
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: January 23, 2008
    Publication date: May 22, 2008
    Inventors: Thomas Stossel, Po-Shun Lee
  • Use of gelsolin to treat infections
    Publication number: 20060009386
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: May 12, 2005
    Publication date: January 12, 2006
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas Stossel, Po-Shun Lee