Abstract: Disclosed is a reusable actuator for use with a drug container including a stopper comprising a container having a closed end, an open end, and a sidewall extending therebetween in a longitudinal direction, an electrode disposed inside the container for use in generating a gas, an actuating element disposed at and closing the open end of the container, the actuating element and the container defining an actuator interior, wherein the actuating element is movable relative to the container in the longitudinal direction by a gas pressure of the gas in the actuator interior, such that the actuating element applies a force to the stopper to cause a drug delivery from the drug container, and a retracting mechanism for use in removing the gas to assist the actuating element's retraction for reuse.

Abstract: Disclosed is a method for controlling an electrochemical pump, comprising: providing an electrochemical pump, and causing a control circuit of the electrochemical pump to generate a pulse signal to enable an electrochemical reaction on electrodes of the electrochemical pump, wherein the pulse signal has alternating on-periods and off-periods where the pulse signal is off, and wherein each on-period has a plurality of on-times where the pulse signal is on and a plurality of off-times where the pulse signal is off, the on- and off-times being alternatingly arranged.

Abstract: An electrochemical pump adopts a hybrid pulse to intermittently activate an electrochemical reaction. The abovementioned electrochemical pump can save power effectively to prolong the lifetime of the electrochemical pump. In addition, an electrochemical pump increases the bonding strength between electrodes and a substrate by covering edges of the electrodes with an insulating layer to avoid electrode delamination caused by high-power electrochemical reactions. A delivery device using the abovementioned electrochemical pump is also disclosed.

Abstract: A micro-delivery device includes a substrate having an upper surface; a shell disposed on the upper surface of the substrate and defining a chamber between the shell and the substrate; a planar electrode disposed on the upper surface of the substrate; a separator disposed in the chamber and dividing the chamber into an upper reservoir and a lower reservoir; and a cannula inserted in an opening of the rigid shell and in fluid communication with the upper reservoir.

Abstract: The electrochemical pump unit of mesh combined electrode of the present invention is connected to a drug injection container for operation, when it is connected to the power supply, the cathode (or anode) enters into electrochemical reaction with the electrolyte of the superabsorbent material layer through the mesh electrode to release a first gas, the first gas flows through the screen meshes of mesh electrode immediately without obstruction loss; the anode (or cathode) enters into electrochemical reaction with the electrolyte on the opposite side of superabsorbent material layer through the plane electrode to release a second gas, the second gas flows through the inter fibrous small space/channels of superabsorbent material layer and the screen meshes of mesh electrode; as the first gas and the second gas increase, the piston is pushed, and the medicament is pushed.

Abstract: A multistage gas-actuated drug supply device is connected to a drug injection container, the features include a gas supply unit, providing a gas; a plunger unit, composed of a plurality of hollow tubes, one end is connected to the gas supply unit, the hollow tubes can be stretched by the gas; a plunger top, connected to the other end of the plunger unit, pushing a medicament as the hollow tubes stretch; a gas chamber, penetrating the plunger unit, connected to the gas supply unit, holding the gas and stretching the hollow tubes as the gas increases, the gas chamber is further expanded; a limit part, located in the coupling end of the connected hollow tubes, limiting the collapsing length of the hollow tubes; and an airtight piece, located in the coupling end of the connected hollow tubes, sealing the gas chamber.

Abstract: An electrochemical pump adopts a hybrid pulse to intermittently activate an electrochemical reaction. The abovementioned electrochemical pump can save power effectively to prolong the lifetime of the electrochemical pump. In addition, an electrochemical pump increases the bonding strength between electrodes and a substrate by covering edges of the electrodes with an insulating layer to avoid electrode delamination caused by high-power electrochemical reactions. A delivery device using the abovementioned electrochemical pump is also disclosed.

Abstract: The present invention provides a delivery device which comprises a substrate, a rigid shell a diaphragm, a cannula, an electrode and an electronic device chamber. The substrate has a first side and a second side. The second side is opposite to the first side. The rigid shell is disposed on the first side of the substrate. A chamber is defined by the rigid shell and the substrate. The diaphragm is configured within the chamber to divide the chamber into an upper reservoir and a lower reservoir. The cannula penetrating through the rigid shell and in fluid communication with the upper reservoir. The electrode is disposed on the first side of the substrate. The electronic device chamber is electrically connecting to the electrode.

Abstract: The disclosure provides an electrochemical pump which comprises a substrate and at least one planar electrode and a micro-delivery device comprising the same. The substrate has an upper surface. The planar electrode is disposed on the upper surface and comprises at least one sharp corner.

Abstract: Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded o the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.

Abstract: The present invention provides a delivery device which comprises a substrate, a rigid shell a diaphragm, a cannula, an electrode and an electronic device chamber. The substrate has a first side and a second side. The second side is opposite to the first side. The rigid shell is disposed on the first side of the substrate. A chamber is defined by the rigid shell and the substrate. The diaphragm is configured within the chamber to divide the chamber into an upper reservoir and a lower reservoir. The cannula penetrating through the rigid shell and in fluid communication with the upper reservoir. The electrode is disposed on the first side of the substrate. The electronic device chamber is electrically connecting to the electrode.

Abstract: Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded o the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.

Abstract: In various embodiments, a needle is employed in refilling drug-delivery devices.

Abstract: Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.

Abstract: Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded to the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.

Abstract: A method for detecting bone structure includes allocating at least one bone portion from a bone image composed by pixels each including luminance value relating to bone structural parameter; aligning a major axis of principal axes of moment of inertia of the bone portion to a principal axis of Cartesian coordinate system; a cortical bone area of the bone portion intersecting at least one principal plane perpendicular to the principal axis, and each principal plane forming an outer and inner contour line of the cortical bone area; processing an analytic algorithm for the bone structural parameter; calculating distributed state of the bone structural parameter in each principal plane to obtain a distributed state of the bone structural parameter of the bone portion; and obtaining a distributed state of the bone structural parameter of the bone portion by assembling distributed state of the bone structural parameter of each bone portion.

Abstract: The present invention provides a method and system for detection of bone structure, the method executing operation process and image reconstruction according to an image of a skeleton captured by CT scanner, to present distributed state of a bone structural parameter of the skeleton for diagnosing.

Abstract: Elastomeric check valves for use, e.g., in small pump devices, may include a molded elastomeric valve body forming a pocket that extends from an opening at the valve inlet to a terminus inside the valve body, and having a slit extending from the terminus to a valve outlet.

Abstract: Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made based on the flow “tail” that occurs in a piston- or plunger-type pump as relaxation of the plunger material continues to push fluid out of the drug reservoir; this residual flow eventually ceases after the plunger returns to its natural state.

Abstract: The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.