Patents by Inventor Poothappillai Kasinathan

Poothappillai Kasinathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGENIC ANIMALS AND USES THEREOF
    Publication number: 20110231943
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Application
    Filed: April 6, 2011
    Publication date: September 22, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: JAMES M. ROBL, YOSHIMI KUROIWA, POOTHAPPILLAI KASINATHAN, ISAO ISHIDA, KAZUMA TOMIZUKA
  • Method of producing xenogenous antibodies using a bovine
    Patent number: 7928285
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: April 19, 2011
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: James M. Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka
  • Transgenic ungulates capable of human antibody production
    Patent number: 7803981
    Abstract: The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: September 28, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: James M. Robl, Philippe Collas, Eddie Sullivan, Poothappillai Kasinathan, Richard A. Goldsby, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara Osborne
  • Transgenic animals and uses thereof
    Publication number: 20090222935
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Application
    Filed: June 25, 2008
    Publication date: September 3, 2009
    Inventors: James M. Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka
  • Transgenic animals and uses thereof
    Patent number: 7420099
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: September 2, 2008
    Assignee: Kirin Holdings Kabushiki Kaisha
    Inventors: James M. Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka
  • Transgenic bovines capable of human antibody production
    Patent number: 7414170
    Abstract: The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: August 19, 2008
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: James M. Robl, Poothappillai Kasinathan, Richard A. Goldsby, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara Osborne
  • Transgenic ungulates capable of human antibody production
    Publication number: 20080040821
    Abstract: The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
    Type: Application
    Filed: June 20, 2007
    Publication date: February 14, 2008
    Inventors: James Robl, Philippe Collas, Eddie Sullivan, Poothappillai Kasinathan, Richard Goldsby, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara Osborne
  • Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
    Patent number: 7253334
    Abstract: The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: August 7, 2007
    Assignee: Aurox, LLC
    Inventors: Philippe Collas, James M. Robl, Eddie Sullivan, Poothappillai Kasinathan
  • Transgenic animals and uses thereof
    Publication number: 20060041945
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Application
    Filed: April 21, 2005
    Publication date: February 23, 2006
    Applicants: Hematech, LLC, Kirin Beer Kabushiki Kaisha
    Inventors: James Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka