Abstract: Functionalized benzocycloheptenes are one of the most important classes of bicyclic framework that have been investi-gated in different areas of biological activities. The claimed invention provides preparations of benzocycloheptene analogues, inhibitors of PI3K and MK2, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I, II, III, IV, V and VI may be used as anti type 2 diabetes, antipyretic, anti-inflammatory, antiepileptic, anticancer, antiulcer, CNS-stimulant, and CNS-depressant. These benzocycloheptene derivatives are useful in treatment of PI3K and MK2 related disorders.

Abstract: The present invention relates to 5-methyl substituted furan compounds of general formula (I) and process for the preparation thereof: ORlR2 R3CH3(1) Particularly, the present invention relates to a metal catalyst and hydrogen gas free, atom-economy, highly selective and low-cost process for the preparation of methyl substituted furan compounds from different aldehyde substituted furan compounds.

Abstract: A tubular string includes a first tubular member with a pin end with pin threads and a pin external load shoulder. The tubular string also includes a second tubular member with a box end with a box external load shoulder and box threads, the pin threads being threadable into the box threads to form a connection, wherein the pin external load shoulder has an outer diameter (OD) that is different than an OD of the box external load shoulder. A load distribution sleeve is locatable between the first and second tubular members when threaded together and includes a first end facing the first tubular member and a second end facing the second tubular member, wherein the ODs of the load distribution sleeve first and second ends match the ODs of the pin and box external load shoulders respectively. The load distribution sleeve contacts the pin and box external load shoulders and distributes a make-up load between the pin and box external load shoulders when the connection is made up.

Abstract: A tubular string includes a first tubular member with a pin end with pin threads and a pin external load shoulder. The tubular string also includes a second tubular member with a box end with a box external load shoulder and box threads, the pin threads being threadable into the box threads to form a connection, wherein the pin external load shoulder has an outer diameter (OD) that is different than an OD of the box external load shoulder. A load distribution sleeve is locatable between the first and second tubular members when threaded together and includes a first end facing the first tubular member and a second end facing the second tubular member, wherein the ODs of the load distribution sleeve first and second ends match the ODs of the pin and box external load shoulders respectively. The load distribution sleeve contacts the pin and box external load shoulders and distributes a make-up load between the pin and box external load shoulders when the connection is made up.

Abstract: The present invention relates to a new protocol for “Process development for 5-hydroxymethylfurfural (5-HMF) synthesis from carbohydrates”. A convenient, atom-economic, highly selective and cost-effective process has been developed for the preparation of 5-HMF from cellulose, hemicellulose, starch, different sources of carbohydrates and further extended to glucose and fructose.

Abstract: The present invention relates to a new protocol for “Process development for 5-hydroxymethylfurfural (5-HMF) synthesis from carbohydrates”. A convenient, atom-economic, highly selective and cost-effective process has been developed for the preparation of 5-HMF from cellulose, hemicellulose, starch, different sources of carbohydrates and further extended to glucose and fructose.

Abstract: A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and ?,?-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.

Abstract: A downhole tool includes a downlinking system deployed in a downhole tool body having an internal through bore. The downlinking system includes a differential pressure transducer configured to measured a pressure difference between drilling fluid in the internal through bore and drilling fluid external to the tool (in the borehole annulus). The differential transducer is electrically connected with an electronic controller (deployed substantially anywhere in the drill string) that is configured to receive and decode pressure waveforms.

Abstract: The present invention relates to new compounds of the formula (I), (II), or (III) wherein R1, R2, R3, R4, R5 and W are as defined herein, and pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloid disease, such as observed in Alzheimer's disease, infectious diseases, PAI-I related disease, and in the manufacture of medicaments for such treatment.

Abstract: A downhole steering tool includes distinct hydraulic and electronics modules deployed about a shaft. The hydraulics module includes a plurality of hydraulically actuated blades. The electronics module includes electronic circuitry configured to control blade actuation. The hydraulics and electronics modules are physically and electrically connected to one another via a timed connection.

Abstract: A downhole tool includes a downlinking system deployed in a downhole tool body having an internal through bore. The downlinking system includes a differential pressure transducer configured to measured a pressure difference between drilling fluid in the internal through bore and drilling fluid external to the tool (in the borehole annulus). The differential transducer is electrically connected with an electronic controller (deployed substantially anywhere in the drill string) that is configured to receive and decode pressure waveforms.

Abstract: A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and ?,?-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.

Abstract: A downhole tool includes a slip ring assembly deployed radially between a shaft and a housing. The slip ring assembly may be configured as a stand-alone assembly and is further configured to provide a plurality of distinct electrical communication channels between the shaft and housing. These communication channels are suitable for transmitting electrical power and/or electronic data. Electrical connection is made between the housing and the slip ring assembly via a connector block that is fastened to a plurality of stator rings in the slip ring assembly. The connector block extends radially outward from the stator rings and physically engages an opening in the housing thereby rotationally coupling the stator rings to the housing.

Abstract: A downhole tool includes a downlinking system deployed in a downhole tool body having an internal through bore. The downlinking system includes a differential pressure transducer configured to measured a pressure difference between drilling fluid in the internal through bore and drilling fluid external to the tool (in the borehole annulus). The differential transducer is electrically connected with an electronic controller (deployed substantially anywhere in the drill string) that is configured to receive and decode pressure waveforms.

Abstract: A downhole steering tool includes distinct hydraulic and electronics modules deployed about a shaft. The hydraulics module includes a plurality of hydraulically actuated blades. The electronics module includes electronic circuitry configured to control blade actuation. The hydraulics and electronics modules are physically and electrically connected to one another via a timed connection.

Abstract: The present invention relates to new compounds of the formula (I), (II), or (III) wherein R1, R2, R3, R4, R5 and W are as defined herein, and pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloid disease, such as observed in Alzheimer's disease, infectious diseases, PAI-I related disease, and in the manufacture of medicaments for such treatment.

Abstract: A downhole tool includes a slip ring assembly deployed radially between a shaft and a housing. The slip ring assembly may be configured as a stand-alone assembly and is further configured to provide a plurality of distinct electrical communication channels between the shaft and housing. These communication channels are suitable for transmitting electrical power and/or electronic data. Electrical connection is made between the housing and the slip ring assembly via a connector block that is fastened to a plurality of stator rings in the slip ring assembly. The connector block extends radially outward from the stator rings and physically engages an opening in the housing thereby rotationally coupling the stator rings to the housing.

Abstract: The present invention relates to new compounds of formula (I), (II), or (III) wherein R1, R2, R3, R4, R5 and W are as defined herein, and methods of using the compounds to inhibit PAI-1 and to treat PAI-1 related disorders.