Patents by Inventor Pranab K. Chanda

Pranab K. Chanda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PCR-DIRECTED GENE SYNTHESIS FROM LARGE NUMBER OF OVERLAPPING OLIGODEOXYRIBONUCLEOTIDES
    Publication number: 20080182296
    Abstract: The present invention provides methods of PCR-directed gene synthesis that may be used for all genes, including those with a high G+C content and/or a long sequence. The invention relates to methods of gene synthesis using overlapping oligonucleotides and polymerase chain reaction (PCR), wherein several PCR parameters, e.g., the concentration of overlapping oligonucleotides, the type of DNA polymerase used, and the number of PCR amplification cycles, are optimized. Additionally, the invention relates to oligonucleotide design that allows for increased protein expression of synthesized genes.
    Type: Application
    Filed: January 31, 2008
    Publication date: July 31, 2008
    Inventors: Pranab K. Chanda, Bart W. Nieuwenhuijsen
  • Recombinant adenovirus vaccines
    Publication number: 20040170647
    Abstract: This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 2, 2004
    Applicant: Wyeth
    Inventors: Alan R. Davis, Michael D. Lubeck, Robert J. Natuk, Pranab K. Chanda, Shridhara C. S. Murthy, Shaw-Guang L. Lee, Paul P. Hung
  • Methods for producing an immune response against HIV-1
    Patent number: 6511845
    Abstract: This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: January 28, 2003
    Inventors: Alan R. Davis, Paul P. Hung, Michael D. Lubeck, Robert J. Natuk, Pranab K. Chanda, Shridhara C. S. Murthy, Shaw-Guang L. Lee
  • Isolation and purification of the R18 antigen of HTLV-III
    Patent number: 5063053
    Abstract: The isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a portein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-IIIB cell line from viral genomes of related viruses.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: November 5, 1991
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: Flossie Wong-Stal, Pranab K. Chanda, John Ghrayeb
  • Isolation and purification of the eighth gene of HTLV-III
    Patent number: 4963497
    Abstract: The present invention is the isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-III cell line from viral genomes of related viruses (i.e., other HTLV-III isolates, LAV, ARV, etc.).
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: October 16, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Flossie Wong-Staal, Pranab K. Chanda, John Ghrayeb