Abstract: Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic schemes are also disclosed.

Abstract: The present disclosure provides a process for the preparation a premix of raltegravir potassium form 3 with excipients. This premix may be used in the manufacture of pharmaceutical formulations containing raltegravir.

Abstract: Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic schemes are also disclosed.

Abstract: The present disclosure provides a process for the preparation a premix of raltegravir potassium form 3 with excipients. This premix may be used in the manufacture of pharmaceutical formulations containing raltegravir.

Abstract: The present disclosure provides a process for the preparation of 2-(2-amino propan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxamide by debenzylation of benzyl(2-{4-[(4-fluorobenzyl)carbamoyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl}propan-2-yl)carbamate. This process may be used in the synthesis of raltegravir and pharmaceutically acceptable salts thereof.

Abstract: A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates for the synthesis of canagliflozin (Formula 4, Formula 4a, Formula 4b and Formula 5) are also disclosed. The process involves the reduction of the compound of formula 3 in the presence of a metal hydride and an organic solvent to obtain the compound of formula 4, converting this into a compound of formula 5 which in turn is converted into canagliflozin.

Abstract: Disclosed are a system, a method and/or an apparatus of a shareable virtual non-volatile storage device for a server. In one embodiment, the system includes a server, a storage array, a management processor, and a switching fabric. The storage array includes a storage device coupled with a controller associated with a shared driver to receive a data request from the server at a remote location from the storage array through the switch fabric via a communication link to direct the data request to the storage device coupled with it and transmit data to the server through the switch fabric. A virtual storage device is generated in the server to enable the server to share the shared driver in the storage array with other servers through the switch fabric between the server and the storage array. The server distributes the data across the storage devices through the shared driver.

Abstract: The present invention relates to a non-solvated crystalline Darunavir, process for its preparation and pharmaceutical composition comprising it. The present invention also relates to a process for the preparation of amorphous Darunavir from a non-solvated crystalline Darunavir.

Abstract: The present invention relates to a non-solvated crystalline Darunavir, process for its preparation and pharmaceutical composition comprising it. The present invention also relates to a process for the preparation of amorphous Darunavir from a non-solvated crystalline Darunavir.

Abstract: The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Abstract: A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R, 3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R, 3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.

Abstract: The present invention relates an improved process for the preparation of 2-arylthiazole derivatives which are intermediates of Febuxostat and further conversion to Febuxostat or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to a novel process for the preparation of Fosamprenavir or its pharmaceutically acceptable salts thereof by using novel intermediates.

Abstract: Disclosed are a system, a method and/or an apparatus of a shareable virtual non-volatile storage device for a server. In one embodiment, the system includes a server, a storage array, a management processor, and a switching fabric. The storage array includes a storage device coupled with a controller associated with a shared driver to receive a data request from the server at a remote location from the storage array through the switch fabric via a communication link to direct the data request to the storage device coupled with it and transmit data to the server through the switch fabric. A virtual storage device is generated in the server to enable the server to share the shared driver in the storage array with other servers through the switch fabric between the server and the storage array. The server distributes the data across the storage devices through the shared driver.

Abstract: The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Abstract: A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R,3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.

Abstract: The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

Abstract: A method in a computer network for automatically detecting a most advantageous protocol for communication by a client computer, said client computer being configured to be coupled to a server computer via a computer network. The method includes initiating a plurality of protocol threads for sending from the client computer to the server computer, a plurality of data requests. Each of the data requests employs a different protocol and a different connection. The data requests are configured to solicit, responsive to the data request, a set of responses from the server computer. Each of the responses employs a protocol associated with a respective one of the data requests. The method further includes receiving at the client computer at least a subset of the responses. The method also includes initiating a control thread at the client computer.

Abstract: The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

Abstract: The production of synchronization scripts and associated annotated multimedia streams for servers and client computers coupled to each other by a diverse computer network which includes local area networks (LANs) and/or wide area networks (WANs) such as the intermet. Annotated multimedia streams can include a compressed video stream for display in a video window, an accompanying compressed audio stream and annotations. Synchronization scripts include annotation streams for synchronizing the display of video streams with annotations, e.g., displayable events, such textual/graphical data in the form of HTML pages with Java applets to be displayed in one or more event windows. The producer includes a capture module and an author module for capturing video streams and generating annotation streams, respectively. The capture module compresses the video stream using a suitable compression format.