Patents by Inventor Praveen Kumar Vemula

Praveen Kumar Vemula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130280334
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: September 23, 2011
    Publication date: October 24, 2013
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20120321573
    Abstract: The present invention relates to compositions and methods for inhibiting metal exposure to tissues.
    Type: Application
    Filed: October 1, 2010
    Publication date: December 20, 2012
    Applicants: THE GENERAL HOSPITAL CORPORATION, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Richard Rox Anderson
  • Publication number: 20120263765
    Abstract: A composition includes an isolated cell; at least one particle within said cell; and at least one active agent associated with the particle, wherein the active agent is capable of being released from the cell. A method includes administration of such a cell to a subject.
    Type: Application
    Filed: October 15, 2010
    Publication date: October 18, 2012
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Jeffrey M. Karp, Debanjan Sarkar, Praveen Kumar Vemula
  • Publication number: 20120251443
    Abstract: The present disclosure provides compositions and methods based on implantable contrast agents that are useful for imaging tissue and organs.
    Type: Application
    Filed: October 1, 2010
    Publication date: October 4, 2012
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: C. Keith Ozaki, Jeffrey M. Karp, Frank Rybicki, Dimitrios Mitsouras, Praveen Kumar Vemula
  • Publication number: 20120201863
    Abstract: The present invention relates to a method for thickening a hydrophobic liquid. When a hydrophobic liquid is thickened in accordance with the invention, the liquid becomes significantly denser. Preferably, the hydrophobic liquid becomes a gel.
    Type: Application
    Filed: July 29, 2010
    Publication date: August 9, 2012
    Inventors: George John, Swapnil R. Jadhav, Praveen Kumar Vemula
  • Publication number: 20110229565
    Abstract: This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.
    Type: Application
    Filed: September 17, 2009
    Publication date: September 22, 2011
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, George John, Greg Cruikshank
  • Publication number: 20110206740
    Abstract: The present invention is directed to methods and compositions for engineering the surface of a cell, wherein a targeting moiety and/or a particle are attached to the cell membrane. The particle can further comprise a therapeutic agent for drug delivery. The compositions disclosed herein are useful in the treatment of diseased or damaged tissue by targeting cells for the purpose of tissue regeneration, drug delivery or a combination of both.
    Type: Application
    Filed: April 29, 2009
    Publication date: August 25, 2011
    Inventors: Jeffrey M. Karp, Debanjan Sarkar, Praveen Kumar Vemula
  • Publication number: 20110189250
    Abstract: The present invention generally relates to a method of making nanoparticles and uses thereof. In particular, the invention relates to methods of making metal nanoparticles (MNPs). The invention also relates to antimicrobial uses of the nanoparticles.
    Type: Application
    Filed: January 15, 2009
    Publication date: August 4, 2011
    Inventors: George John, Praveen Kumar Vemula, Pulickel Ajayan, Ashavani Kumar
  • Publication number: 20100129451
    Abstract: A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis.
    Type: Application
    Filed: November 24, 2008
    Publication date: May 27, 2010
    Inventors: George John, Praveen Kumar Vemula