Patents by Inventor Praveen Paul
Praveen Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230212499Abstract: The bioprocessing perfusion system (10) includes a bioreactor (12) and a feed flow path (14). A first tangential flow filter (16) is coupled to the bioreactor (12) via the feed flow path (14) and a second tangential flow filter (18) is coupled to the bioreactor (12) via the feed flow path (14). The first tangential flow filter (16) is a microfiltration-type filter and the second tangential flow filter (18) is an ultrafiltration-type filter. The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to a receiving unit (58) via the permeate flow path (60). The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to the bioreactor (12) via the retentate flow path (46).Type: ApplicationFiled: July 13, 2021Publication date: July 6, 2023Inventors: Sahebagouda Alagur, Prashanth Hosabettu Mohan, Praveen Paul
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Publication number: 20230031710Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.Type: ApplicationFiled: December 17, 2020Publication date: February 2, 2023Inventors: Praveen Paul, Sahebagouda Alagur, Thomas Falkman, Prashanth Hosabettu Mohan
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Publication number: 20220372422Abstract: Systems (100) and methods for perfusion control in a bioreactor (120) are provided. The system (100) comprises a media container (110) connected to the bioreactor (120) and weighing scales (113, 123) measure weight of the bioreactor (120) and the media container (110). A plurality of controllers (225, 245) are connected to the weighing scales and configured to continuously feed the media from media container (110) to the bioreactor (120) at a user defined rate using a motor pump (112). A filter (130) is provided to receive feed from the bioreactor (120) through a recirculation line (121) and a permeate flow line (141) is connected to the filter (130) to flow out the permeate from the filter (130).Type: ApplicationFiled: August 5, 2020Publication date: November 24, 2022Inventors: Sudeep Kumar DAM, Praveen PAUL, Prashanth H M, Pradeep KUMAR, Victor JOSE, Sahebagouda ALAGUR, Mandar Chandrakant NARVEKAR, Thomas FALKMAN, Ajay GORE
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Patent number: 11452976Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: GrantFiled: December 22, 2017Date of Patent: September 27, 2022Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Patent number: 11415241Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.Type: GrantFiled: July 19, 2019Date of Patent: August 16, 2022Assignee: Cytiva Sweden ABInventors: Prashanth Hosabettu Mohan, Ajit S. Vernekar, Praveen Paul, Krishnadev Madhavan Nair, Manjunath Bhat
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Patent number: 11326142Abstract: Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.Type: GrantFiled: August 25, 2016Date of Patent: May 10, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Haresh Digambar Patil, Anoop Bhargav, Praveen Paul, Sebastian John
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Publication number: 20210395664Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).Type: ApplicationFiled: September 20, 2019Publication date: December 23, 2021Inventors: Praveen Paul, Prashanth Hosabettu Mohan, Ajay Gore, Sahebagouda Alagur
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Publication number: 20210261900Abstract: A method includes inducing a first quantity of a feed fluid (28) to flow along a first direction (72) from a bioreactor (12) to a tangential flow filter (16) to separate the first quantity of the feed fluid (28) into a permeate fluid (42) and a retentate fluid (48). Further, the control unit (66) is operated to control at least one feed flow control device (24, 26) to inhibit the flow of first quantity of the feed fluid (28). Furthermore, the control unit (66) is operated to control the at least one feed flow control device (24, 26) to direct at least one of further flow of a second quantity of the feed fluid (28) from the bioreactor (12), a portion of the permeate fluid (42), and a portion of a nutrient fluid, along a second direction (74) opposite to the first direction (72) via the tangential flow filter (16).Type: ApplicationFiled: August 20, 2019Publication date: August 26, 2021Inventors: Anoop Bhargav, Praveen Paul, Prashanth Hosabettu Mohan, Ajay Gore, Pradeep Kumar, Victor Jose, Sahebagouda Alagur, Melissa Marie Semple, Mark David Roberts
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Publication number: 20210140558Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.Type: ApplicationFiled: July 19, 2019Publication date: May 13, 2021Inventors: Prashanth Hosabettu Mohan, Ajit S. Vernekar, Praveen Paul, Krishnadev Madhavan Nair, Manjunath Bhat
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Patent number: 10995312Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Patent number: 10995310Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Patent number: 10934518Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: GrantFiled: January 29, 2016Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Publication number: 20190388855Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: ApplicationFiled: December 22, 2017Publication date: December 26, 2019Inventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Publication number: 20190309251Abstract: A tray configured to be provided on a base station of a bioreactor system, said tray comprising a bottom and surrounding side walls and being configured to hold a bioreactor bag, said bottom comprising at least two bottom parts, whereof one is a middle part of the bottom, wherein at least one of the bottom parts is movable into at least a first and a second position, wherein said first position provides the bottom parts substantially flush with each other providing a substantially plane bottom of the tray and said second position provides a bottom of the tray having a recessed middle part.Type: ApplicationFiled: October 26, 2017Publication date: October 10, 2019Applicant: General Electric CompanyInventors: Haresh Digambar PATIL, Anoop BHARGAV, Praveen PAUL, Sebastian JOHN
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Publication number: 20190017011Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: ApplicationFiled: August 25, 2016Publication date: January 17, 2019Applicant: General Electric CompanyInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Publication number: 20180251715Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180251722Abstract: Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Haresh Digambar PATIL, Anoop BHARGAV, Praveen PAUL, Sebastian JOHN
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Publication number: 20180250666Abstract: Disclosed is biomanufacturing apparatus (1) comprising a housing (20), a substantially enclosed bioreactor chamber (30) inside the housing and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use the tray (40) including a heater (42) for contacting a bioreactor and heating the same, and the apparatus further comprising secondary heating (53) for heating air surrounding the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180002655Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: ApplicationFiled: January 29, 2016Publication date: January 4, 2018Inventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Patent number: D776825Type: GrantFiled: February 10, 2016Date of Patent: January 17, 2017Assignee: General Electric CompanyInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary