Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: The present disclosure describes compositions and methods for treating ornithine transcarbamylase (OTC) deficiency. The compositions include a lipid formulation and messenger RNA (mRNA) encoding an OTC enzyme. The lipid formulations can comprise an ionizable cationic lipid in a lipid nanoparticle encapsulating the mRNA.

Abstract: What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus, method, and computer program product are described that provide for a visual indication of an operation to be performed, such that a user, upon applying a first portion of a user input, may be able to determine from the visual indication whether the input applied, when completed, will cause the desired operation to be performed. The apparatus may provide for the display of a screen having a representation of interactive content, and an input may be received from the user that includes a contact component and a movement component, such as a stroke gesture. In response to receipt of the contact component and prior to receipt of the movement component, the apparatus may provide for a visual indication of an operation to be performed. The operation may be executed based on receipt of at least a portion of the movement component.

Abstract: A method for providing a notification mechanism may include causing provision of a notification bar at an edge of a touch screen display in response to an occurrence of an event where the notification bar provides information indicative of the event, enabling, responsive to user input, extension of the notification bar away from the edge of the touch screen display to display one or more levels of other notification classes in addition to the information indicative of the event, causing presentation of the notification bar to remain in an extended position away from the edge of the touch screen display so as to display one or more levels of notification classes upon cessation of the user input and causing, responsive to exposure of each level that has a subsequent level thereafter, an indication of existence of the subsequent level. A corresponding apparatus and computer program product are also provided.

Abstract: A graphical user interface for a computer program, the interface comprising an array of main panes each providing access to a particular aspect of the program, the panes being in register with one another at a vertex corresponding to the area in which all the panes meet, each of the panes being adapted to expand as a pointing device highlights a pane, the expansion of said pane relative to the other panes wherein the panes remain in register with one another at the vertex as a pane expands.

Abstract: The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).

Abstract: This invention relates to a system (2000) for providing individual users access to audio/visual content which has been broadcast to a plurality of users on a scheduled basis. The system comprises means for storing the content, means for enabling a user to download the content in the form of a downloadable file, and means for enabling a user to view the content by opening and playing the downloaded file. The means for opening and playing the downloaded file preferably being adapted to open and/or play the downloaded file only within a fixed time period after the scheduled broadcast time of the content.

Abstract: A method is provided for controlling and customizing a display screen of a user interface which includes at least two sections of display elements with the display elements of one section being displayed in a different manner, such as being sized greater, than the display elements of another section. The method also defines a spatial relationship of the at least two sections. The method also includes receiving an input indicating a selection of a display element and causing the performance of an operation associated with the display element. A corresponding apparatus and computer program product are also provided.

Abstract: This invention relates to a system (2000) for providing individual users access to audio/visual content which has been broadcast to a plurality of users on a scheduled basis. The system comprises means for storing the content, means for enabling a user to download the content in the form of a downloadable file, and means for enabling a user to view the content by opening and playing the downloaded file. The means for opening and playing the downloaded file preferably being adapted to open and/or play the downloaded file only within a fixed time period after the scheduled broadcast time of the content.

Abstract: An apparatus comprising at least one processor; and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to perform at least the following: identify user application events associated with one or more contacts of an electronic device; and collate the user application events associated with one or more particular contacts, with the corresponding particular contact.

Abstract: An apparatus, method, and computer program product are described that provide for a visual indication of an operation to be performed, such that a user, upon applying a first portion of a user input, may be able to determine from the visual indication whether the input applied, when completed, will cause the desired operation to be performed. The apparatus may provide for the display of a screen having a representation of interactive content, and an input may be received from the user that includes a contact component and a movement component, such as a stroke gesture. In response to receipt of the contact component and prior to receipt of the movement component, the apparatus may provide for a visual indication of an operation to be performed. The operation may be executed based on receipt of at least a portion of the movement component.

Abstract: A method for providing a notification mechanism may include causing provision of a notification bar at an edge of a touch screen display in response to an occurrence of an event where the notification bar provides information indicative of the event, enabling, responsive to user input, extension of the notification bar away from the edge of the touch screen display to display one or more levels of other notification classes in addition to the information indicative of the event, causing presentation of the notification bar to remain in an extended position away from the edge of the touch screen display so as to display one or more levels of notification classes upon cessation of the user input and causing, responsive to exposure of each level that has a subsequent level thereafter, an indication of existence of the subsequent level. A corresponding apparatus and computer program product are also provided.

Abstract: A method is provided for controlling and customizing a display screen of a user interface which includes at least two sections of display elements with the display elements of one section being displayed in a different manner, such as being sized greater, than the display elements of another section. The method also defines a spatial relationship of the at least two sections. The method also includes receiving an input indicating a selection of a display element and causing the performance of an operation associated with the display element. A corresponding apparatus and computer program product are also provided.

Abstract: A graphical user interface for a computer program, the interface comprising an array of main panes each providing access to a particular aspect of the program, the panes being in register with one another at a vertex corresponding to the area in which all the panes meet, each of the panes being adapted to expand as a pointing device highlights a pane, the expansion of said pane relative to the other panes wherein the panes remain in register with one another at the vertex as a pane expands.

Abstract: The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since 127 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).

Abstract: This invention relates to a system (2000) for providing individual users access to audio/visual content which has been broadcast to a plurality of users on a scheduled basis. The system comprises means for storing the content, means for enabling a user to download the content in the form of a downloadable file, and means for enabling a user to view the content by opening and playing the downloaded file. The means for opening and playing the downloaded file preferably being adapted to open and/or play the downloaded file only within a fixed time period after the scheduled broadcast time of the content.