Patents by Inventor Pyung-Gang Lee

Pyung-Gang Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED BOTULINUM NEUROTOXIN A PROTEASE DOMAIN WITH IMPROVED EFFICACY
    Publication number: 20240158773
    Abstract: Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified protease domains of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations, isolated modified protease domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.
    Type: Application
    Filed: March 14, 2022
    Publication date: May 16, 2024
    Applicant: Children's Medical Center Cprporation
    Inventors: Min Dong, Pyung-Gang Lee
  • IMPROVED RECEPTOR-BINDING DOMAIN OF BOTULINUM NEUROTOXIN A AND USES THEREOF
    Publication number: 20240082369
    Abstract: Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified receptor binding domain of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations. Isolated modified receptor binding domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.
    Type: Application
    Filed: December 20, 2021
    Publication date: March 14, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Min Dong, Pyung-Gang Lee