Abstract: The present invention relates to a composition for preventing, improving or treating a mental disorder, the composition containing a Lactobacillus sp. bacteria-derived vesicle as an active ingredient. The present inventors have confirmed that, when a Lactobacillus sp. bacteria-derived vesicle is administered to a stress and depression animal model, resistance to stress efficiently increases, and an effect of treating chronically persisting long-term depression behavior is exhibited, and thus the Lactobacillus sp. bacteria-derived vesicle, according to the present invention, is expected to be capable of being usefully employed in developing a medicine or a functional health food, etc., for preventing, reducing the symptoms of or treating a mental disorder such as stress, anxiety disorder, post-traumatic stress disorder, panic disorder, depression, autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia.

Abstract: The present invention relates to a method of diagnosing Alzheimer's dementia by bacterial metagenomic analysis, and more particularly, to a method of diagnosing Alzheimer's dementia and mild cognitive impairment by analyzing an increase or decrease in contents of specific bacterial extracellular vesicles by performing bacterial metagenomic analysis using normal person and subject-derived samples. The extracellular vesicles secreted from bacteria present in the environment are absorbed into the body and penetrate into brain tissue to have a direct influence on a cognitive function such as Alzheimer's dementia, and since Alzheimer's dementia is difficult to be diagnosed early before symptoms are shown, effective treatment is difficult.

Abstract: The present invention relates to a composition for preventing, improving or treating a mental disorder, the composition containing a Lactobacillus sp. bacteria-derived vesicle as an active ingredient. The present inventors have confirmed that, when a Lactobacillus sp. bacteria-derived vesicle is administered to a stress and depression animal model, resistance to stress efficiently increases, and an effect of treating chronically persisting long-term depression behavior is exhibited, and thus the Lactobacillus sp. bacteria-derived vesicle, according to the present invention, is expected to be capable of being usefully employed in developing a medicine or a functional health food, etc., for preventing, reducing the symptoms of or treating a mental disorder such as stress, anxiety disorder, post-traumatic stress disorder, panic disorder, depression, autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia.

Abstract: Disclosed is a pharmaceutical composition containing a compound useful for inhibiting neurotoxicity caused by beta amyloid. The pharmaceutical composition of the present disclosure contains 1,3,5,7-tetrakis(aminomethyl)adamantane, an analogous compound thereof or a salt thereof as an active ingredient. The inventors have studied methods for reducing the toxicity of beta amyloid oligomers based on the formation mechanism of dodecamers in consideration of the fact that especially the dodecamers from among the beta amyloid oligomers exhibit a significant activity as a toxin for synapses and neurons in cranial nerve diseases. The inventors have confirmed that the disclosed compound can induce structural epitope deformation of the dodecamer and thereby reduce toxicity of the beta amyloid oligomers.

Abstract: The present invention is related to a transgenic animal inducing Alzheimer's disease. More particularly, the present invention is a vector for transformation of animal comprising a carboxyl-terminal fragments of mutant human beta amyloid protein which contains Indiana mutation (?CTF99) and a transgenic mouse inducing Alzheimer's disease prepared by microinjection of the same into a pronuclei of a fertilized oocyte. The transgenic mouse of the present invention exhibited clinical symptoms of Alzheimer's disease such as decreased of cognitive ability and memory, and increases of anxiety. Therefore, the transgenic mouse of the present invention will be useful animal model for a research of Alzheimer's disease. Particularly, since the transgenic mouse of the present invention showed more remarkable decreases of cognitive ability than any other transgenic animal model for Alzheimer's disease known in the art, the transgenic mouse of the present invention can be used as an animal model for disease relating anxiety.