Abstract: Data format conversion processing of an accelerator accessed by a processor of a computing environment is reduced. The processor and accelerator use different data formats, and the accelerator is configured to perform an input conversion to convert data from a processor data format to an accelerator data format prior to performing an operation using the data, and an output conversion to convert resultant data from accelerator data format back to processor data format after performing the operation. The reducing includes determining that adjoining operations of a process to run on the processor and accelerator are to be performed by the accelerator, where the adjoining operations include a source operation and destination operation. Further, the reducing includes identifying for removal output data format conversion of output data of the source operation for input to the destination operation, and input data format conversion of the input to the destination operation.

Abstract: Disclosed are an optimization method and apparatus for an Interferometric Synthetic Aperture Radar (InSAR) time-series phase. The optimization method includes: obtaining a time-series SAR data set, and performing registration and L-looks processing on the time-series SAR data set to obtain an L-looks intensity data set and an interferometric data set respectively; taking the L-looks intensity data set as a reference, obtaining a preset digital elevation model (DEM) and a preset land cover image, performing registration and geocoding on the preset DEM to obtain a digital elevation in a SAR image coordinate system, and performing registration and geocoding on the preset land cover image to obtain a land cover image in the SAR image coordinate system; performing a differential operation on the interferometric data set to obtain a differential interferometric data set; and estimating a covariance matrix at each spatial pixel position, and estimating and obtaining an optimized time-series phase.

Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Abstract: A semiconductor structure and its fabrication method are provided in the present disclosure. The method includes providing a layer to-be-etched, including first regions and second regions. The method further includes forming a plurality of discrete first sacrificial layers on the layer to-be-etched, where a plurality of openings is between the plurality of first sacrificial layers and includes first openings on the first regions. The method further includes forming initial sidewall spacer structures on sidewalls of the plurality of first sacrificial layers, where the initial sidewall spacer structures include first sidewall spacers, and the first sidewall spacers fill the first openings. The method further includes, using the first sidewall spacers as an alignment mark, forming a first mask layer on the layer to-be-etched and the initial sidewall spacer structures, where the first mask layer exposes a portion of the layer to-be-etched and a portion of the initial sidewall spacer structures.

Abstract: The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire expression and high-throughput screening. The invention also relates to primers useful for PCR amplification of nucleotide sequences encoding human antibody variable domains.

Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.

Abstract: The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire expression and high-throughput screening. The invention also relates to primers useful for PCR amplification of nucleotide sequences encoding human antibody variable domains.

Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.

Abstract: The invention relates to Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) antagonists, such as antibodies and fragments, as well as methods, uses and combinations.

Abstract: A source code defining record structure of data is received. The source code includes data tags which provide information for processing to be performed on the data. Data tagging metadata is generated based on the source code, and the data tagging metadata includes record structure information and the data tags. And data is processed according to the data tagging metadata.

Abstract: A computer-implemented method for proactive change verification is provided. Aspects include analyzing runtime execution characteristics from a plurality of base activity metrics and a plurality of experimental activity metrics and creating a plurality of activity pairs wherein each activity pair comprises a base activity metric and its corresponding experimental activity metric. Aspects also include identifying significant activity pairs from the plurality of activity pairs wherein the experimental activity significantly deviates from its corresponding base activity and classifying significant activity pairs by deviation type. Aspects further include sorting activity pairs by their impact and removing activity pairs that have an impact of less than a threshold amount, wherein the threshold amount is based on the deviation type.

Abstract: Techniques for profile clustering for homogenous instance analysis are described herein. An aspect includes collecting for each of a plurality of homogenous instances in a cloud computing environment, respective profiling information, the profiling information comprising counter data. Another aspect includes identifying a code unit for analysis. Another aspect includes aggregating counters corresponding to the code unit for each of the plurality of homogenous instances from the respective profiling information. Another aspect includes determining a cluster comprising a subset of the plurality of homogenous instances based on the aggregated counters.

Abstract: In one embodiment of the present disclosure, an original graph including nodes is obtained. The nodes of the original graph are reordered to generate a reordered graph. Non-zero elements in an adjacency matrix for the reordered graph are clustered as compared with an adjacency matrix for the original graph. The adjacency matrix for the reordered graph is encoded with integers. The integers correspond to non-empty blocks in the adjacency matrix for the reordered graph.

Abstract: Techniques for profile clustering for homogenous instance analysis are described herein. An aspect includes collecting for each of a plurality of homogenous instances in a cloud computing environment, respective profiling information, the profiling information comprising counter data. Another aspect includes identifying a code unit for analysis. Another aspect includes aggregating counters corresponding to the code unit for each of the plurality of homogenous instances from the respective profiling information. Another aspect includes determining a cluster comprising a subset of the plurality of homogenous instances based on the aggregated counters.

Abstract: A method, computer system, and computer program product for accelerating class data loading in a containers environment are provided. In response to a first container in a containers environment being created from a first image, at least one archive file containing a set of classes from the first image can be loaded. Then a respective class sharing file for each of the at least one archive file can be generated. The class sharing file is stored in a shared location. A second container in the containers environment is created from a second image. If a class sharing file from the archive is found in the shared location, that class sharing file can be used.

Abstract: Antibodies that bind to the circumsporozoite protein (CSP) of Plasmodium falciparum. Use of such antibodies as anti-malarial agents, to confer protection against infection by malarial parasites such as P. falciparum by insect vector transmission. Diagnosis of malaria using anti-CSP antibodies. Methods of determining efficacy of candidate vaccine compositions in development and testing of anti-malarial vaccines.

Abstract: A computer-implemented method, a computer system, and a computer program product for trajectory similarity search is provided. The present invention may include, in response to receiving, by one or more processors, a search request for at least one trajectory similar to a query trajectory, determining, by one or more processors, a respective similarity between a query trajectory and a plurality of trajectories by calculating, in a synchronized way, a spatial distance measure and a time difference measure between the query trajectory and the plurality of trajectories. The present invention may further include, identifying, by one or more processors, the at least one trajectory from the plurality of trajectories based on the respective similarity between the query trajectory and the plurality of trajectories.