Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A salt of a nitrogen-containing fused heterocyclic compound or a crystal form thereof, and a preparation method therefor, a pharmaceutical composition thereof, and a use thereof, in particular, a salt of compound I as shown below or a crystal form thereof, and a preparation method, a pharmaceutical composition and a use. The salt of compound I or the crystal form thereof exhibits at least one of the following advantages: improved bioavailability, great mechanical properties, improved chemical stability, excellent fluidity, great compressibility, and improved dissolution characteristics.

Abstract: A metabolic enzyme-induced micro-nano plastic particle biodegradation method and a product analysis method therefor are disclosed. The biodegradation method includes the following steps: step (1), cutting an appropriate quantity of plastic products into small pieces; step (2), placing the plastic products in a ball mill tank and milling the plastic products in vacuum in a ball mill; step (3), weighing and dispersing the milled plastic sample with water to prepare a dispersion with a concentration; step (4), mixing the micro-nano plastic dispersion with a metabolic enzyme solution, and placing the mixed solution in a vortex oscillator for mixing well; and step (5), incubating the mixed solution in a waterproof incubator. The present invention provides for the first time a method for biodegradation and metabolism of micro-nano plastics under mild conditions and under the induction of a metabolic enzyme, namely, glutathione S-transferase.

Abstract: Provided is a touch display panel. The touch display panel includes a drive back plate; a light-emitting device, disposed on the drive back plate; an encapsulation layer, disposed on a side of the light-emitting device distal from the drive back plate; and a touch layer, disposed on a side of the encapsulation layer distal from the light-emitting device, wherein the touch layer includes a first touch electrode layer and a second touch electrode layer laminated in sequence, and the touch layer further includes a touch insulating layer.

Abstract: A liquid-cooled plate radiator is disclosed. The liquid-cooled plate radiator includes a radiator body. A coolant liquid runner for circulating a coolant liquid is formed inside the radiator body. The coolant liquid runner includes a plurality of radiating sub-runners. Then, a plurality of fin units are arranged on the radiating sub-runners along a flow direction of the coolant liquid. The fin unit has a plurality of fins extending side by side along the flow direction of the coolant liquid. Moreover, the fins of the front and rear adjacent fin units on the radiating sub-runners are staggered, thereby increasing the radiating area, enhancing the disturbance of the coolant liquid when flowing inside the radiating sub-runners, and improving the radiating efficiency. Thus, the technical problems of limited radiating area and low radiating efficiency caused by a single linear coolant liquid runner are solved.

Abstract: Disclosed a method for predicting permeability of a multi-mineral phase digital core based on deep learning. In the present disclosure, a three-dimensional digital core is constructed and a pore structure is randomly generated; after a plurality of multi-mineral digital core images is acquired by performing image segmentation on the three-dimensional digital core, permeability corresponding to each of the multi-mineral digital core images is acquired by simulation using multi-physics field simulation software and a multi-mineral digital core data set is constructed based on the plurality of multi-mineral digital core images and the permeability corresponding to each of the multi-mineral digital core images; an SE-ResNet18 convolutional neural network is constructed and trained with the multi-mineral digital core data set; and an image of a multi-mineral core to be predicted is input into the trained SE-ResNet18 convolutional neural network to determine the permeability of the multi-mineral core.

Abstract: Provided are methods and apparatus for automated process configuration and information storage. In an example, a computer-implemented method includes (i) accessing a database of information describing a plurality of steps, where the steps are ordered; (ii) retrieving, from the database, information describing a step in the plurality of steps; (iii) presenting, via a user interface, the information describing the step; (iv) requesting, via the user interface, a user input in response to the presented information; (v) receiving, from the user interface, information describing the user input; (vi) storing, in the database, the information describing the user input, where the storing includes affiliating the information describing user input and the information describing the step with a corresponding identifier; and (vii) identifying, based upon the user input, a next step in the plurality of steps. Other methods and apparatus are also disclosed.

Abstract: Some embodiments provide an automated method for defining externally routable Pods within a Kubernetes cluster. In some embodiments, the Pod operates in a guest cluster has its own VPC (virtual private cloud) network in a datacenter with several other guest clusters that have their own VPC networks and their own set of managers. In some embodiments, a Pod within a GC can be made externally routable so that it can be directly addressable from an external client outside of the Pod's network by using two new Kubernetes CRDs (custom resource definitions), which are an IPPool CRD and a RouteSet CRD. Examples of such external clients include VMs or Pods in another GC or a supervisor cluster connected to the particular GC through a gateway, or from a machine outside of the network of all of the GCs or SC.

Abstract: The present invention relates to the technical field of endoscopes, and discloses a confocal endoscope with a fixing device.

Abstract: Provided by the present application are a method and a device for constructing integrated space-terrestrial network, the method including: obtaining a target constellation and standardizing a relative motion between each target satellite in the target constellation and earth's surface according to a principle of making a satellite running in a recursive earth-repeat orbit have fixed satellite subpoint trajectories; obtaining a recursively extended topological structure according to the target constellation; according to the extended topological structure, dividing geographical cells and obtaining a mapping relationship between the geographical cells and the satellite subpoint trajectories to facilitate network addressing and networking management based on geographical location; and performing, based on a deployment rule, a recursive incremental deployment according to the extended satellite network topological structure, and realizing integrated space-terrestrial network.

Abstract: Embodiments of a channel hole plug structure of 3D memory devices and fabricating methods thereof are disclosed. The memory device includes an alternating layer stack disposed on a substrate, an insulating layer disposed on the alternating dielectric stack, a channel hole extending vertically through the alternating dielectric stack and the insulating layer, a channel structure including a channel layer in the channel hole, and a channel hole plug in the insulating layer and above the channel structure. The channel hole plug is electrically connected with the channel layer. A projection of the channel hole plug in a lateral plane covers a projection of the channel hole in the lateral plane.

Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.

Abstract: A gas-exhausting apparatus includes a gas-exhausting body and a gas-exhausting mechanism. The gas-exhausting mechanism includes a connecting assembly and a gas-ventilating member. The connecting assembly includes first and second connecting members. The first connecting member is provided with a first through hole for communicating with an inside of the battery cell. The second connecting member is provided with a second through hole for communicating with an outside of the battery cell. The first connecting member is configured to attach to a surface of the gas-ventilating member facing the inside of the battery cell. The second connecting member is configured to attach to a surface of the gas-ventilating member facing away from the inside of the battery cell. An orthographic projection of the first through hole on the gas-ventilating member and an orthographic projection of the second through hole on the gas-ventilating member are arranged to be staggered from each other.

Abstract: A resource processing method and apparatus. The method is achieved by a computer configured to execute the following steps: generating a resource allocation chart based on a resource allocation request; processing the resource allocation chart and generating an access entrance of the resource allocation chart; opening the access entrance to enable at least one third party resource supplier to respond to the resource allocation request via the access entrance. The method further comprises: when the resources are not available or not suitable for allocation, receiving a resource allocation chart, wherein the resource allocation chart is based on the resource allocation request; generating an access entrance of the resource allocation chart; opening the access entrance to at least one third party resource supplier; and receiving the allocated resources from the at least one third party resource supplier by responding to the resource allocation request through the access entrance.

Abstract: Disclosed are various approaches for workflow service application searching. In some aspects, a search query is entered through a search element of a workflow application on a client device. A request is transmitted from a workflow application to a workflow service, to search within an application based on the search query. Application content corresponding to the search query and the application is received from the workflow service. A search result is provided based on the application content and without opening the application on the client device.

Abstract: A display panel and a display device are disclosed. The display panel includes a photoresist layer, a liquid crystal layer, and a total reflection layer. Liquid crystal molecules included in the liquid crystal cells have a first refractive index and a second refractive index. The first refractive index is greater than the second refractive index, and a refractive index of the total reflection units matches with the first refractive index. The display panel and the display device not only have advantages of low manufacturing cost and eye protection, but can also achieve color and dynamic display.

Abstract: A method for preparing acetic acid by catalyst including the following steps is provided, S1. preparing the hydrotalcite carrier by hydrothermal method; S2. ion exchange; S3. liquid phase reduction; S4. placing the CoPd/LDH catalyst obtained in S3 in a two-channel fixed bed step-by-step continuous reactor, carrying out the reaction at 100-400° C. and 0.1-20 MPa, synthesizing acetic acid by alternating feeding of CH4+H2+H2O and CO2+H2+H2O, with the alternating time of 50-300 s. The present invention replaces the traditional process of acetic acid production including the steps of methane and carbon dioxide reforming to produce syngas. The process flow is short, the reaction conditions are mild, and the energy consumption and cost are greatly reduced.

Abstract: A light-emitting device, a light-emitting substrate, and a method for manufacturing the light-emitting device. The light-emitting device includes at least one light-emitting structure. The light-emitting structure includes: a first semiconductor layer; a light-emitting layer; a second semiconductor layer, doping ions of the second semiconductor layer and a first semiconductor layer being oppositely charged; a barrier structure provided with an opening for exposing the second semiconductor layer, the orthographic projection of the opening on the base substrate being located in the orthographic projection of the light-emitting layer on the base substrate, and the area of the opening being smaller than that of the light-emitting layer; and a landing electrode located on the side of the barrier structure facing away from the second semiconductor layer, the landing electrode being in contact with the second semiconductor layer by means of the opening.

Abstract: A nuclear emergency multifunctional operation robot includes a base, a mechanical arm, a tool change-over device, and motion supporting devices. The base includes a pedestal, a mounting seat A, a mounting seat B, a mounting seat C, a rotation driving mechanism A, and a rotation driving mechanism B. The front end of the mechanical arm is connected to the mounting seat B; the tool change-over device includes a male connector and a female connector which are abutted with or separated from each other; and the motion supporting devices are used to drive the nuclear emergency multifunctional operation robot to move. The present disclosure has the advantages that the base can be integrated with various end tools, so that the operation robot conveniently changes over tools according to operation needs to conduct various types of operations.

Abstract: An assembled subway station and a construction method thereof are provided. The assembled subway station includes a plurality of components combined in a ring shape, comprising a bottom plate component, two bottom corner components, two side wall components, a middle plate component, two top corner components, and a top plate component. Connection surfaces of each component are each provided with a concave-convex structure being matched with another concave-convex structure on a relevant connection surface of an adjacent component. Butt joint positions of two adjacent components are filled with sealing structures. The embedded grooves of two adjacent components are oppositely arranged, and connecting members for exerting opposite fastening forces on the two adjacent components are installed in the oppositely arranged embedded grooves.