Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A method can include determining candidate sidelink resources by a user equipment (UE) for sidelink transmission on an unlicensed band from a sidelink resource selection window based on results of a sensing operation on the unlicensed band during a sidelink sensing window, selecting a sidelink resource from the candidate sidelink resources, performing a listen-before-talk (LBT) process on the unlicensed band to obtain a channel occupancy time (COT), and performing a sidelink transmission within the COT using the first sidelink resource. The selection of the sidelink resource can be based on an LBT time that is a predicted duration of a random backoff process of the first LBT process. Also, the first sidelink resource can be selected from the candidate sidelink resources without randomization.

Abstract: A method can include determining candidate sidelink resources by a user equipment (UE) for sidelink transmission on an unlicensed band from a sidelink resource selection window based on results of a sensing operation on the unlicensed band during a sidelink sensing window, selecting a sidelink resource from the candidate sidelink resources, performing a listen-before-talk (LBT) process on the unlicensed band to obtain a channel occupancy time (COT), and performing a sidelink transmission within the COT using the first sidelink resource. The selection of the sidelink resource can be based on an LBT time that is a predicted duration of a random backoff process of the first LBT process. Also, the first sidelink resource can be selected from the candidate sidelink resources without randomization.

Abstract: Apparatus and methods are provided for sidelink resource selection in unlicensed frequency bands. In one novel aspect, a combination of SL resource selection procedure and a listen-before-talk (LBT) procedure are used for resource selection in unlicensed frequency bands. In one embodiment, the LBT procedure is performed after the SL resource selection procedure. In one embodiment, the candidate resource selected by the SL resource selection procedure has an overbooking resource size larger than or equal to a resource size required for the SL data transceiving. In another embodiment, the overbooking resource size is dynamically determined based on one or more preconfigured conditions comprising an LBT failure probability, channel loading status information, and channel congestion control information. In yet another embodiment, the candidate resources are multi-consecutive-slot (MCSt) resources with configured multiple consecutive resource blocks.

Abstract: Tools for identifying risk of cerebral edema in a stroke patient are provided and include a method that involves identifying risk of cerebral edema when cytokines and chemokines are detected in a systemic blood sample from the subject.

Abstract: Provided are a tail point detection method and apparatus, a device, and a storage medium. The implementation scheme includes acquiring a target audio; identifying a sentence pattern type of the target audio; determining detection waiting duration according to the sentence pattern type; and determining a result of detecting a tail point of the target audio according to the detection waiting duration.

Abstract: A visualized surgical assembly is provided, characterized in that the visualized surgical assembly includes a disposable drainage tube and a functional tube for providing visualization function, the disposable drainage tube and the functional tube are connected detachable along the axial of the tube body, and the functional tube is provided with a self-destructive part for cutting the disposable drainage tube. A corresponding endoscope is also provided. The visualized surgical assembly is a combination structure of the disposable drainage tube and the functional tube which can provide visualization function. The disposable drainage tube can removable connect with the functional tube, and the functional tube can be repeated disinfection, which can reduce the cost and avoid the risk of cross infection.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The presently-disclosed subject matter generally to methods for identifying and analyzing biomarkers to determine group effects. The presently-disclosed subject matter also relates to methods for identifying genes and proteins that increase or decrease in response to ischemic stroke damage. The disclosed subject matter further describes methods of predicting edema and infarct volume in a patient. Also described herein are methods of determining the necessity of intervention for smokers. Further disclosed herein, are methods for testing therapies for ischemic stroke.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

Abstract: The present disclosure relates to the technical field of Internet, and provides a user registration method, a user login method and a device corresponding thereto. In these methods, a passport or the user card records identity information of the autonomous identity of a user, and the user can use the passport or the user card to access an application website, which is unlike the conventional method of performing the accessing through the account and the password. Moreover, the present disclosure further implements a series of mechanisms from the application to the use, concerning the passport and the user card.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A visualized surgical assembly is provided, characterized in that the visualized surgical assembly includes a disposable drainage tube and a functional tube for providing visualization function, the disposable drainage tube and the functional tube are connected detachable along the axial of the tube body, and the functional tube is provided with a self-destructive part for cutting the disposable drainage tube. A corresponding endoscope is also provided. The visualized surgical assembly is a combination structure of the disposable drainage tube and the functional tube which can provide visualization function. The disposable drainage tube can removable connect with the functional tube, and the functional tube can be repeated disinfection, which can reduce the cost and avoid the risk of cross infection.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.