Abstract: The present invention belongs to the field of pharmaceutical manufacturing technology. The present invention provides a pharmaceutical composition of a conjugate and a preparation method thereof. The pharmaceutical composition is preferably administered by injection. The docetaxel conjugate has a structural formula as shown in the following formula: (I).

Abstract: The invention discloses a biological desulfurizer for removing organic sulfur in fracturing flowback fluid and application thereof. The biological desulfurizer includes a compound with a triazine structure formed by modifying chitosan with aldehydes and inorganic salts. The triazine structure has a good removal effect on hydrogen sulfide and organic sulfur such as mercaptan and sulfide. The biological desulfurizer of the invention has a sulfur capacity of up to 250 g/kg and a desulfurization efficiency of over 95% in 15 min. It can effectively remove the stink of sulfur-containing working water, improve the working environment of the well site, and reduce the impact of sulfur compounds on the atmospheric environment during the development of oil and gas fields.

Abstract: A pretreatment method for producing a raw material of lycopene, comprising: uniformly mixing tomato peel residue with a fermenting agent, an antioxidant and an enzyme preparation, and subjecting the resultant to light-proof anaerobic fermentation. The present invention employs bacteria-enzyme-combined fermentation technology, which prolongs the storage period of wet tomato peel residue, and also destroys the cell wall of tomato peels, thus facilitating exaction of lycopene and improving the purity of lycopene extracted in the later stage.

Abstract: The present invention relates to a method for preparing lycopene crystals with high purity and low harm. The method comprises the following steps: (1) mixing lycopene oleoresin with a mixed solvent consisting of an alkane and a lower alcohol, and heating and stirring the resultant for dissolution to form a homogenous solution; (2) cooling the homogenous solution for crystallization, filtering the resultant to obtain a filter cake; and (3) washing the filter cake successively using a lower alcohol and an alkane, and drying the resultant to obtain lycopene crystals. According to the method provided by the present invention, lycopene crystals can be obtained using a mixed solvent by means of one step crystallization, and the crystal content is further improved and harmful substances in the crystals are reduced by means of a two-step crystal washing process to obtain lycopene crystals with high purity and low harm.

Abstract: The present invention relates to a method for preparing lycopene crystals with high purity and low harm. The method comprises the following steps: (1) mixing lycopene oleoresin with a mixed solvent consisting of an alkane and a lower alcohol, and heating and stirring same for dissolution to form a homogenous solution; (2) cooling and crystallizing the homogenous solution, filtering same to obtain a filter cake; (3) washing the filter cake successively using a lower alcohol and an alkane, and drying same to obtain lycopene crystals. According to the method provided by the present invention, lycopene crystals can be obtained using a mixed solvent by means of one step crystallization, and the crystal content is further improved and harmful substances in the crystals are reduced by means of a two-step crystal washing process to obtain lycopene crystals with high purity and low harm.

Abstract: A pretreatment method for producing a raw material of lycopene, comprising: uniformly mixing tomato peel residue with a fermenting agent, an antioxidant and an enzyme preparation, and subjecting the resultant to light-proof anaerobic fermentation. The present invention employs bacteria-enzyme combined fermentation technology, which prolongs the storage period of wet tomato peel residue, and also destroys the cell wall of tomato peels, thus facilitating exaction of lycopene and improving the purity of lycopene extracted in the later stage.