Abstract: The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Abstract: The present disclosure discloses a treatment process and treatment system of enhanced up-flow multiphase wastewater oxidation. The treatment process includes the following steps: 1) the wastewater is fed into the up-flow multiphase wastewater oxidation system for oxidation treatment; 2) the wastewater is fed to the solid-liquid separation system for solid-liquid separation, the separated heterogeneous catalytic carrier (5) is fed back to the up-flow multiphase wastewater oxidation system, and the wastewater is fed to the neutralization and degassing system; 3) the wastewater is fed to the neutralization and degassing system to adjust a pH of the wastewater to 5.5-7.5, and then is degassed by stirring; 4) the wastewater is fed to the flocculation and sedimentation system for sludge-water separation, a supernatant is discharged, and an outward harmless treatment is performed after a pressure filtration of a sedimentary iron sludge.

Abstract: The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Abstract: Provided are an anti-Claudin18.2 antibody or an antigen binding fragment thereof, a pharmaceutical composition comprising an anti-Claudin18.2 antibody or an antigen binding fragment thereof, and uses thereof. The antibody and Claudin18.2 have significant binding activity and affinity, have efficient in-vitro ADCC cytotoxic activity against a tumor cell, and can be applied in the preparation of an antineoplastic drug.

Abstract: A maintenance tool for an insulator of a direct current transmission line comprises clamping devices and a tensioning device. The clamping devices are mounted at the two sides of the insulator through clamping, and the tensioning device is connected between the clamping devices. The clamping devices comprise a closed clamp (1), a single serial clamping device (2) and a wire end clamping device (30). The clamping device has advantages such as strong overall strength and bearing capacity, small size, light weight, and reliable working, and can be applied to replacement of various insulators on the direct current transmission line, reliably ensuring safe commissioning and regular maintenance of transmission lines.

Abstract: A maintenance tool for an insulator of a direct current transmission line comprises clamping devices and a tensioning device. The clamping devices are mounted at the two sides of the insulator through clamping, and the tensioning device is connected between the clamping devices. The clamping devices comprise a closed clamp (1), a single serial clamping device (2) and a wire end clamping device (30). The clamping device has advantages such as strong overall strength and bearing capacity, small size, light weight, and reliable working, and can be applied to replacement of various insulators on the direct current transmission line, reliably ensuring safe commissioning and regular maintenance of transmission lines.