Abstract: Disclosed herein are gene therapy vectors used for efficiently transducing cells to express a human ?-globin gene. Specifically disclosed is an expression vector which comprises: an expression cassette for a ?-globin gene, which comprises exons and introns of human ?-globin gene, as well as cis-acting elements including one or more of WPRE, SV40 polyadenylation signal and/or SV40 ori. The disclosed expression vectors have significantly enhanced viral vector packaging efficiency in viral vector packaging cell lines, which leads to effective integration of lentiviral vectors and high expression level of ?-globin gene in target cells. Also disclosed are pharmaceutical compositions and therapeutic methods utilizing such expression vectors.

Abstract: An electrode plate stacking method includes: determining, based on a first electrode plate, a conveying order of a plurality of second electrode plates, the first electrode plate being a continuous electrode plate, the plurality of second electrode plates including at least one upper electrode plate and at least one lower electrode plate, the plurality of second electrode plates being discontinuous electrode plates, and the conveying order being used for conveying the at least one upper electrode plate and the at least one lower electrode plate alternately; generating an identifier sequence for the plurality of second electrode plates based on the conveying order; and collecting first image data of each of the plurality of second electrode plates based on the identifier sequence in a process of conveying the plurality of second electrode plates in the conveying order.

Abstract: The present disclosure relates to the technical field of multimedia, and in particular, to a control method and apparatus for multimedia content display, an electronic device, and a medium. First multimedia content is displayed on a first page; and in response to a terminal device changing in a preset attitude, the first page is switched to a second page, and second multimedia content is displayed on the second page. That is, the switching of the first page to the second page is implemented by triggering the attitude change of the terminal device, thereby improving the interestingness of user interaction.

Abstract: The present application discloses a semi-dominant molecular marker related to maize dwarf and an application thereof, and relates to the technical field of maize molecular breeding. The molecular marker related to the maize dwarf is caused by a non-synonymous mutation from G to A in a maize gene Zm00001d013465, and the molecular marker is a nucleotide sequence composed of the non-synonymous mutation site and its upstream and downstream bases. The present application identifies a dwarf mutant, coded as E5779, from an EMS mutation population with maize B73 as the genetic background. By genome resequencing and Mutmap mapping, it is found that the mutant is caused by the non-synonymous mutation from G to A in the gene Zm00001d013465. The molecular marker is developed based on this, and the analysis and utilization of E5779 are helpful to improve the maize plant height and density-tolerant breeding, it has an important breeding application potential.

Abstract: The present invention provides a detection reagent and therapeutic target for B cell tumor after targeted therapy and related applications. The reagent composition comprises 3 groups of antibodies, with the first group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD24 an antibody, an anti-CD20 antibody, an anti-CD81 antibody, an anti-CD45 antibody; the second group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD20 antibody, an anti-CD72 antibody, an anti-CD45 antibody; and the third group of antibodies including an anti-cytoplasmic CD79a antibody. The reagent composition of the present invention can be applied for the detection of B-lymphocyte tumors after targeted therapy by flow cytometry.

Abstract: A JAK inhibitor may be used in preparation of a medicament. The medicament may be used for preventing and/or treating a disease or condition associated with an antitumor agent in a subject. A pharmaceutical composition may include the JAK inhibitor as may a kit. The JAK inhibitor may include a compound of formula (I) or a pharmaceutically acceptable salt thereof: Q, X, Y, and Z being independently N or C, and R1, R2 and R3 being independently a 5-6-membered aromatic ring, 5-6-membered heteroaromatic ring, 5-6-membered cycloalkyl, 5-6-membered heterocycloalkyl, amino, or amido, the aromatic ring, heteroaromatic ring, cycloalkyl, and/or heterocycloalkyl being optionally substituted by a substituent.

Abstract: A method for controlling a device for automatically adjusting an airway opening body position is provided. The device includes a horizontal base plate, a head support block, a back support plate, a neck support apparatus, a head cover assembly, and a programmable logic controller (PLC). The neck support apparatus is positioned between the head support block and the back support plate. The PLC is configured to controls a stroke of an electric cylinder according to the following equations: ?=1.235?+?, and ?=KX+B+C, where ? is a body position angle, the body position angle is an angle between a positive projection line of a connecting line from a mandibular angle to an external acoustic meatus on a symmetrical surface of a human body and the back support plate, and ? is a preset value ranging from 90° to 100°.

Abstract: The present disclosure relates to a construction method for a deformable anchor cable capable of being prestressed. The anchor cable includes an outer sleeve, a shrinkage pipe, an inner sleeve, a steel strand, an anchor and a tray. When the anchor cable is in use, a hole is drilled first, then the anchor cable is mounted in the drilled hole, and finally a prestress is applied to the steel strand of the anchor cable. According to the construction method, the construction is convenient; the anchor cable has the characteristics of high strength and large deformation, and can be easily prestressed; and the large deformation is realized by squeezing the inner sleeve by means of the anchor, which completely overcomes the problem of breaking a cold-drawn rod during the large deformation process.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: A method for scheduling and displaying three-dimensional annotations is provided, relating to the field of realistic three-dimensional visualization technology. The present disclosure covers data services, data scheduling schemes, data storage schemes, annotation avoidance schemes, and annotation efficient display schemes. Users can use this disclosure to schedule and display massive three-dimensional annotations in WebGL at high frame rates while consuming extremely low performance. It solves the problem of text inversion and non-hierarchical zooming of three-dimensional maps in traditional annotation and slicing services which can cause text to appear larger or smaller, breaking through the technical bottleneck that traditional annotation and slicing services that cannot be superposition displayed on 3D models.

Abstract: A method that includes collecting, by a computer, social network posts by social network friends of a user containing images. The method further includes identifying, by the computer, images within the social network posts containing the user through facial image recognition based on an image of the user in a user social network profile and determining, by the computer, information from the identified images containing the user within the social network posts for inclusion in the user social network profile. The method may further include updating, by the computer, the profile information of the user social network profile to include the information from the identified images containing the user within the social network posts.

Abstract: An information handling system may include at least one processor and a memory. The information handling system may be configured to: execute an application comprising a plurality of microservices on the at least one processor, wherein the application is configured to service external requests by executing a plurality of application programming interface (API) calls among the plurality of microservices; and for each API call: determine a span ID associated with such API call; determine a trace ID associated with a particular external request that is associated with such API call; and log the span ID and the trace ID.

Abstract: An electrode plate deviation correction method includes collecting, by sensors, deviation data of an edge of an electrode plate relative to a preset boundary, determining a deviation correction displacement of the electrode plate according to the deviation data, controlling, according to the deviation correction displacement, an unwinding apparatus for the electrode plate to adjust a position of the electrode plate so that the deviation data of the electrode plate relative to the preset boundary is within a target range.

Abstract: The present invention provides a flame-retardant pressure-sensitive adhesive, comprising reaction products of the following reaction compositions based a total weight of the reaction compositions as 100 wt. %: 35-99 wt. % of a (meth)acrylate copolymer containing a functional reactive functional group, the functional reactive functional group comprising one or a plurality of the following groups: carboxyl group, hydroxyl group and epoxy group; the (meth)acrylate copolymer containing the functional reactive functional group being formed by free radical polymerization of one or a plurality of monomers; and 1-65 wt. % of a reactive organophosphorus flame retardant capable of reacting with the functional reactive functional group, the reactive organophosphorus flame retardant being formed by reaction of reaction components comprising the following substances: a compound or oligomer containing n epoxy groups, wherein n>=2, and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide.

Abstract: A diaphragm detection method includes acquiring a target image of an electrode plate to be detected. The electrode plate to be detected includes an anode electrode plate and diaphragms respectively stacked on two sides of the anode electrode plate. The method further includes performing image processing on the target image to determine a target image region in the target image, and performing diaphragm misalignment detection on the electrode plate to be detected based on the target image region.

Abstract: A control method includes during a transmission process of a battery electrode plate to a defect rejection mechanism as driven by a drive mechanism, upon a defective electrode plate detection mechanism detecting that the battery electrode plate is a defective electrode plate, recording a first distance of the defective electrode plate, which is a distance from the defective electrode plate to the defect rejection mechanism; obtaining a second distance that the defective electrode plate moves as driven by the drive mechanism, during a transmission process of the defective electrode plate from the defective electrode plate detection mechanism to the defect rejection mechanism; updating the first distance of the defective electrode plate based on the second distance; and controlling the defect rejection mechanism to reject the defective electrode plate, under a condition that the updated first distance of the defective electrode plate satisfies a preset condition.

Abstract: Embodiments of the present application provide an apparatus and a method for manufacturing an electrode assembly. The apparatus includes a driving portion, used for driving pole pieces to fall them from the driving portion; and a first support portion, arranged below the driving portion, and used for receiving the falling pole pieces, so that the pole pieces are stacked on the first support portion. The distance between an initial position of the upper surface of the first support portion and the driving portion being in a range of W to 2W. The initial position is the position of the upper surface of the first support portion when receiving the first pole piece of the electrode assembly, and W is the length of each pole piece. The apparatus can effectively stack the pole pieces to obtain an electrode assembly, and has high stacking efficiency.

Abstract: Embodiments of nitric oxide (NO) generation apparatuses, systems, and methods are provided. In some embodiments, an NO generation apparatus may include a reaction chamber having a liquid region and a gas region. The liquid region may be configured to contain a reaction medium and the gas region may be configured to contain a product gas comprising NO. The NO generation apparatus may also include a plurality of electrodes disposed in the reaction medium, and may include an energy source electrically connected to the plurality of electrodes and configured to apply a predetermined voltage or a predetermined current to at least one of the plurality of electrodes to generate NO. The NO generation apparatus may also include an inlet circuit configured to receive a carrier gas, and may include at least one sparger in fluid communication with the inlet circuit and configured to emanate bubbles of the carrier gas in the reaction medium.