Abstract: Disclosed herein is a multilayer coating system present on a substrate and including at least two coating layers L1 and L2 different from one another, namely a first coating layer L1 applied over at least a portion of the substrate, and a second topcoat layer L2 applied over the first coating layer L1, where the topcoat layer L2 is formed from a coating composition including at least one block copolymer containing a backbone and at least two blocks B1 and B2 and side chains S1 and S2 including different polymeric moieties M1 and M2. Also disclosed herein are a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a method of using a coating composition including the block copolymer for improving, in particular for increasing, the chromaticity of the multilayer coating system.

Abstract: Disclosed herein is a multilayer coating system present on a substrate and including at least three coating layers L1, L2 and L3 different from one another, namely a first pigmented coating layer L1 applied over at least a portion of the substrate, a second coating layer L2 applied over the first pigmented coating layer L1, and a third coating layer L3 applied over the second coating layer L2, where the second coating layer L2 is formed from a coating composition including at least one block copolymer containing a backbone and at least two blocks B1 and B2 and side chains S1 and S2 including different polymeric moieties M1 and M2. Also disclosed herein are a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a method of using a coating composition including the block copolymer for improving the chromaticity of the multilayer coating system.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides a diagnostic kit for metastasis and invasion of breast cancer and a use of an shRNA molecule for silencing expression of human LINC01614. The shRNAs obtained by the invention can interfere with the expression of LINC01614, thereby reducing the migration and invasion ability of tumor cells, inhibiting the expression of EMT proteins, and inhibiting tumor formation and lung metastasis in an animal model in vivo. The invention provides a new solution for targeted therapy of breast cancer. Therefore, the kit for diagnosing metastasis and invasion of breast cancer and the medication for treating metastasis and invasion of breast cancer are developed. The invention provides a new way and strategy for diagnosing and treating metastasis and invasion of breast cancer.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: Described herein is an aqueous basecoat composition. Also described herein are a method of coating a substrate and use of the aqueous basecoat composition for improving the performance properties of basecoat materials.

Abstract: Described herein is a polymeric pigment dispersant, a process for preparation of the polymeric pigment dispersant and a pigment dispersion including the pigment dispersant that is used for coating and in printing ink, automotive basecoat, auto-motive clearcoat, mill base, furniture coatings and wood coatings.

Abstract: Pigmented masonry compositions are provided that include chemically treated carbon black pigments having attached an organic group including an ionic or an ionizable group, the ionic or ionizable group being present at a level from 1.0 to 3.0 ?mol/m2. The compositions exhibit excellent color consistency and jetness and provide consistent color after long term exposure to high levels of moisture.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: The invention provides composite particles comprising core particles having organosilica particles disposed about the core particles. The invention also provides a process for making the composite particles.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: An aqueous carbon black millbase, an aqueous carbon black liquid coating, and a method of making the millbase and liquid coating are provided. The carbon blacks are modified carbon blacks that are engineered to be able to be stirred into an aqueous vehicle without high energy milling of the carbon black. The modified carbon blacks include low organic treatment levels and the millbase and liquid coating do not require large quantities of dispersant. The resulting coatings exhibit excellent viscosity, color, hiding power and stability.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: CMP processes, tools and slurries utilize composite particles that include core particles having organosilica particles disposed about the core particles. Using these processes, tools and slurries can enhance removal rates, reduce defectivity and increase cleanability with respect to comparable systems and substrates.

Abstract: An aqueoue carbon black millbase, an aqueous carbon black liquid coating, and a method of making the millbase and liquid coating are provided. The carbon blacks are modified carbon blacks that are engineered to be able to be stirred into an aqueous vehicle without high energy milling of the carbon black. The modified carbon blacks include low organic treatment levels and the millbase and liquid coating do not require large quantities of dispersant. The resultant coatings exhibit excellent viscosity, color, hiding power and stability.

Abstract: CMP processes, tools and slurries utilize composite particles that include core particles having organosilica particles disposed about the core particles. Using these processes, tools and slurries can enhance removal rates, reduce defectivity and increase cleanability with respect to comparable systems and substrates.

Abstract: Described herein are methods for treating and/or ameliorating a paramyxovirus infection that include using compound (A), or a pharmaceutically acceptable salt thereof.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: The present invention relates to surface modified organic black pigments, surface modified carbon blacks, pigment mixtures and dispersions formed with these pigments, curable compositions, black matrices, and products incorporating them. The surface modified organic black pigment can have attached at least one organic group having the formula -X-Z, wherein X, which is directly attached to the pigment, represents an arylene group, a heteroarylene group, an alkylene group, an aralkylene group, or an alkarylene group, and Z represents at least one ionic group, at least one ionizable group, at least one nonionic group, at least one polymeric group, or any combinations thereof. Also disclosed are carbon black pigment combinations with the surface modified organic black pigments, low dielectric black dispersions, films, and black matrices containing them. Methods of preparing and making these various materials also are provided.