Patents by Inventor Qingwu Jin

Qingwu Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALTERNATIVE PROCESSES FOR THE PREPARATION OF TUBULYSINS AND INTERMEDIATES THEREOF
    Publication number: 20230002440
    Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 5, 2023
    Applicant: Seattle Genetics, Inc.
    Inventors: Kun-Liang WU, Qingwu JIN, Wendel DOUBLEDAY
  • ONE STEP SYNTHESIS FOR ALKYL 2-FLUOROACRYLATES
    Publication number: 20230002306
    Abstract: A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 5, 2023
    Inventors: Qingwu Jin, Michael Whitacre
  • PROCESS FOR THE PREPARATION OF TUBULYSINS AND INTERMEDIATES THEREOF
    Publication number: 20220323601
    Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.
    Type: Application
    Filed: June 8, 2022
    Publication date: October 13, 2022
    Inventors: Kun-Liang WU, Qingwu JIN, Wendel DOUBLEDAY
  • Process for the preparation of tubulysins and intermediates thereof
    Patent number: 11389543
    Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 19, 2022
    Assignee: Seagen Inc.
    Inventors: Kun-Liang Wu, Qingwu Jin, Wendel Doubleday
  • PROCESS FOR THE PREPARATION OF TUBULYSINS AND INTERMEDIATES THEREOF
    Publication number: 20200297864
    Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 24, 2020
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Kun-Liang Wu, Qingwu Jin, Wendel Doubleday
  • PREPARATION OF NUCLEOSIDES RIBOFURANOSYL PYRIMIDINES
    Publication number: 20100056770
    Abstract: The present process provides an improved method for the preparation of 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydrox-ymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase.
    Type: Application
    Filed: October 5, 2007
    Publication date: March 4, 2010
    Inventors: Steven D. Axt, Keshab Sarma, Justin Vitale, Jiang Zhu, Bruce Ross, Suguna Rachakonda, Qingwu Jin, Byoung-kwon Chun
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
    Patent number: 7582756
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: September 1, 2009
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Preparation of nucleosides ribofuranosyl pyrimidines
    Publication number: 20080139802
    Abstract: The present process provides an improved method for converting 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactones derivatives to 3-fluoro-3-methyl-2-chlorofuran compounds which are useful for the synthesis of nucleosides and improved processes for the synthesis of the D-ribonolactone compounds.
    Type: Application
    Filed: October 10, 2007
    Publication date: June 12, 2008
    Inventors: Steven D. Axt, Byoung-Kwon Chun, Qingwu Jin, Suguna Rachakonda, Bruce Ross, Keshab Sarma, Justin Vitale, Jiang Zhu
  • 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20080045709
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • Salts and polymorphs of a pyrrole-substituted indolinone compound
    Patent number: 7247627
    Abstract: The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: July 24, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Andrei Blasko, Qingwu Jin, Qun Lu, Michael A. Mauragis, Dian Song, Brenda S. Vonderwell
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
    Publication number: 20070027149
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 1, 2007
    Inventors: Huiping Guan, Congxin Liang, Connie Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • Process for preparing indolinone derivatives
    Patent number: 7119209
    Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: October 10, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Qingwu Jin, Michael A. Mauragis, Paul D. May
  • Process for preparing indolinone derivatives
    Publication number: 20050171357
    Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 4, 2005
    Inventors: Qingwu Jin, Michael Mauragis, Paul May
  • Salts and polymorphs of a pyrrole-substituted indolinone compound
    Publication number: 20050118255
    Abstract: The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.
    Type: Application
    Filed: September 30, 2004
    Publication date: June 2, 2005
    Inventors: Andrei Blasko, Qingwu Jin, Qun Lu, Michael Mauragis, Dian Song, Brenda Vonderwell
  • Quinuclidines-substituted-multi-cyclic-heteroaryls for treatment of disease
    Publication number: 20050059698
    Abstract: The invention provides the malate salt of compounds of Formula I: A-NH-C(O)-B.X??Formula I wherein X is malate salt, including D- or L-; wherein A is wherein B is or pharmaceutical composition, racemic mixture, or pure enantiomer thereof. The compounds of Formula I are useful to treat diseases or conditions in which ?7 is known to be involved.
    Type: Application
    Filed: May 4, 2004
    Publication date: March 17, 2005
    Inventors: Jon Selbo, Michael Hawley, Qingwu Jin, Daniel Walker
  • 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
    Publication number: 20040102510
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: September 8, 2003
    Publication date: May 27, 2004
    Applicants: SUGEN, INC., PHARMACIA & UPJOHN COMPANY
    Inventors: Huiping Guan, Congxin Liang, Connie Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Process for preparing indolinone derivatives
    Publication number: 20030229229
    Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.
    Type: Application
    Filed: February 14, 2003
    Publication date: December 11, 2003
    Inventors: Qingwu Jin, Michael A. Mauragis, Paul D. May
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
    Patent number: 6653308
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: November 25, 2003
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors
    Publication number: 20030092917
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: February 15, 2002
    Publication date: May 15, 2003
    Applicant: SUGEN, INC.
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis