Abstract: A knowledge graph updating method, an apparatus, an electronic device, a storage medium and a program thereof, relates to the field of computer technology. The method includes: receiving an updating request of a technical knowledge graph, the updating request includes: a technical-event node of the technical knowledge graph; extracting historical event information corresponding to the technical-event node from the technical knowledge graph; and updating event information of the technical-event node after a current time by using a target-technical-event prediction model; wherein, the target-technical-event prediction model is obtained by training a technical-event prediction model with the historical event information.

Abstract: Provided is a fusion protein of human serum albumin or a wild type thereof and human interleukin-2 or a mutation thereof, said fusion protein has a significantly extended in vivo half-life relative to recombinant interleukin-2, can be used alone for treating a tumor, and improves anti-tumor efficacy of an anti-PD-1 antibody or an anti PD-L1-antibody.