Abstract: The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

Abstract: A light-emitting device is provided. The light-emitting device generates a white light and includes at least one light-emitting diode. The at least one light-emitting diode generates a light beam with a broadband blue spectrum and includes a first semiconductor layer, a second semiconductor layer and a multiple quantum well structure. The multiple quantum well structure is located between the first semiconductor layer and the second semiconductor layer, and includes well layers and barrier layers. The well layers include a first well layer, a second well layer and third well layers different in indium concentrations. The first well layer has the largest indium concentration, and the third well layers have the smallest indium concentration.

Abstract: There is provided a light emitting device, for example a grow-light, comprising: a first solid-state light source that generates blue light with a blue photon flux; and a second solid-state light source that generates red light with a red photon flux; wherein a ratio of the blue photon flux to red photon flux is from about 1:3 to about 3:1. It may be that the broadband blue light substantially matches at least one of: the absorption peak wavelength of chlorophyll-a; the absorption peak wavelength of chlorophyll-b; and the absorption peak wavelength of carotenoid.

Abstract: The present disclosure provides LPA antagonists, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating LPA-associated diseases, disorders, and conditions.

Abstract: Techniques for MRI pre-scan method may automatically determine and apply a compensation frequency to correct for inhomogeneous magnetic fields, improving the efficiency and quality of clinical examinations. The method may include executing a first pulse sequence with an MRI system, acquiring multiple magnetic resonance signals at different offset frequencies from the same location, and recording corresponding k space data. Variations between the k space data may be calculated and used to determine the compensation frequency. By applying the compensation frequency to correct for inhomogeneous magnetic fields, artifacts in MRI images can be eliminated, resulting in higher quality images. This method offers a quantitative and automated solution for compensating for inhomogeneous magnetic fields during MRI pre-scans, improving the accuracy and efficiency of clinical examinations. The invention also includes a dedicated MRI pre-scan device.

Abstract: A light-emitting diode is provided. The light-emitting diode includes a P-type semiconductor layer, a N-type semiconductor layer, and a light-emitting stack located therebetween. The light-emitting stack includes a plurality of well layers and a plurality of barrier layers that are alternately stacked, the well layers includes at least one first well layer, at least one second well layer, and third well layers that have different indium concentrations. The first well layer has the largest indium concentration, and the third well layers have the smallest indium concentration. Three of well layers that are closest to the P-type semiconductor layer are the third well layers, and the first well layer is closer to the N-type semiconductor layer than the P-type semiconductor layer.

Abstract: The present invention belongs to the field of medicinal chemistry. Disclosed are a pyridine oxynitride, a preparation method therefor and the use thereof. Specifically, the present invention relates to a series of sodium ion channel blockers with a new structure, a preparation method therefor and the use thereof. The structure thereof is as shown in general formula (I) below. The compounds or a stereoisomer, a racemate, a geometric isomer, a tautomer, a prodrug, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof and a pharmaceutical composition can be used for treating or/and preventing related diseases mediated by a sodium ion channel (NaV).

Abstract: A method and apparatus for susceptibility-weighted imaging, and a magnetic resonance imaging system. The method includes, in planar echo imaging of a plurality of excitations, performing flow compensation in directions of layered encoding, phase encoding, and frequency encoding for echoes of each excitation; after determination of excitation each time, when a linear reordering mode is adopted, for excitation each time, collecting each echo towards space k in a positive direction or a negative direction from the central echo of the plurality of echoes, and collecting echoes of the current excitation in a direction opposite to a direction of collecting echoes of the previous excitation; and subjecting the collected echoes to susceptibility-weighted imaging. An aspect of the present disclosure allows a reduction of flow artifacts in an image created by susceptibility-weighted imaging based on a planar echo sequence.

Abstract: A method for protecting content of online conversational content. The method provides for scanning content of an online conversational exchange between a first device and a second device. A sensitive object included in the content of the online conversation exchange is identified, based on object type information accessible from a protection policy included in respective user profiles. A pseudonymized-object-holder is assigned to the identified sensitive object according to the protection policy of the respective user profiles, and the identified sensitive object identified in the content of the online conversation exchange and stored on both the first device and the second device is replaced with a pseudonymized-object-holder, based on the sensitive-object protection policy of the respective user profiles.

Abstract: There is provided a light emitting device, for example a grow-light, comprising: a grow-light comprising: a broadband blue solid-state light source that generates broadband blue light with a peak emission wavelength from 420 nm to 495 nm and a full width at half maximum of at least 30 nm. It may be that the broadband blue light substantially matches at least one of: the absorption peak wavelength of chlorophyll-a; the absorption peak wavelength of chlorophyll-b; and the absorption peak wavelength of carotenoid.

Abstract: The invention provides an indolizine compound represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method and a use thereof. The indolizine compound has an inhibitory effect on wild-type and/or mutant EZH2 or EZH1, and is expected to be developed into a novel drug for anti-tumor or for the treatment of autoimmune diseases.

Abstract: Techniques are disclosed based on balanced steady state free precession sequence. The techniques include determining a readout gradient of climbing period, platform period, and descent period, and performing a balanced steady state free precession sequence in which the readout gradient is applied in the readout direction, the analog-to-digital conversion module for collecting k-space data is activated during the climbing period maintained in the on state during the platform period, and deactivated during the descent period. The technique includes converting the k-space data collected by the analog-to-digital conversion module into uniform k-space data and generating a magnetic resonance image based on the uniform k-space data. The techniques yield more running time of the readout gradient for data acquisition, reduce the data reading time, and shorten the scanning time. The techniques also reduce the accumulated phase of the field non-uniformity in the echo interval to reduce black band artifacts.

Abstract: A method may include sending a first machine learning model to one or more optical systems in which the first machine learning model is configured to predict span losses in the optical systems. Each respective optical system may be configured to identify the span losses associated with the respective optical system and locally train the first machine learning model according to the respective identified span losses to obtain a respective local first machine learning model that includes one or more respective local model parameters. The method may include obtaining the respective local model parameters from each respective optical system without obtaining the corresponding respective locally trained first machine learning model. The method may also include generating a second machine learning model based on the obtained local model parameters. The second machine learning model may be used to predict occurrences of span losses corresponding to a given optical system.

Abstract: A method for replaying a log on a data node, a data node, and a database system are described. The method is used to improve a log replay speed, and includes: the data node obtaining a plurality of logs, wherein the plurality of logs includes at least one transaction commit log and at least one page operation log; and a first thread of a plurality of threads replaying the at least one page operation log, and a same second thread replaying all page operation logs including an operation on a same page. As such, log replay progress does not need to be synchronized between threads. A process in which the first thread replays the transaction commit log is independent of a process in which at least one second thread replays the at least one page operation log.

Abstract: The data acquisition device may include a fat-suppression pulse exertion module configured to exert a fat-suppression pulse on an imaging area at set intervals, the fat-suppression pulse being able to suppress an initial fat signal to a negative value and keep the fat signal corresponding to the intermediate echo datum of the echo data collected between two fat-suppression pulses within [0, a], and a being a preset threshold close to 0, and an excitation and acquisition module, configured to exert a radio frequency pulse train and a series of phase encoding gradients after each fat-suppression pulse, collect the corresponding echo data, and fill the echo data into K-space in linear filling mode.

Abstract: A light emitting diode package structure is provided. The light emitting diode package structure includes first and second chips. A value of an intensity of a peak wavelength of a first shoulder wave of the first chip divided by an intensity of a peak wavelength of a first main wave of the first chip is defined as a first intensity ratio. A value of an intensity of a peak wavelength of a second shoulder wave of the second chip divided by an intensity of a peak wavelength of a second main wave of the second chip is defined as a second intensity ratio. The first and second chips satisfy “a difference between the intensities of the peak wavelengths of the first and second main waves being less than or equal to 2.5 nanometers” and “a difference between the first and second intensity ratios being greater than 0.1”.

Abstract: A Time-of-flight (TOF) MRI scanning method may include: a TOF MRI scan including a first slice selection gradient applied in the Z direction at the same time as an RF pulse being applied to an imaging target; after applying the RF pulse and first slice selection gradient has ended, applying a slice selection encoding gradient and a phase encoding gradient in the Z direction and Y direction respectively; when application of the slice selection encoding gradient and phase encoding gradient ends, applying a readout gradient in the X direction; when application of the readout gradient ends, applying a tracking saturation pulse to the imaging target, and simultaneously applying a second slice selection gradient in the Z direction; when application of the tracking saturation pulse ends, applying a spoiler gradient in the X, Y and/or Z directions of the magnetic field. The method advantageously reduces the TOF MRI scanning time.

Abstract: A light emitting device is provided. The light emitting device includes a light emitting assembly having a first light emitting diode package structure and a second light emitting diode package structure. The light emitting assembly can generate a mixed light source having a spectral deviation index. The first light emitting diode package structure can generate a first light source having a first spectral deviation index. The second light emitting diode package structure can generate a second light source having a second spectral deviation index. When the first light source and the second light source are within a range from 460 to 500 nm, a sum of the first spectral deviation index and the second spectral deviation index is within a range from ?0.3 to 0.3, and a difference between the first spectral deviation index and the second spectral deviation index is at least greater than 0.2.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: An example method may include obtaining network information of a network and determining a second path from a first node of multiple nodes to a second node of the multiple nodes. The network information may include a network topology that may include the multiple nodes and multiple links connecting the multiple nodes. The multiple links may include a first routing metric and a second routing metric. The network information may also include multiple first paths from each node of the multiple nodes to all other nodes of the multiple nodes along the multiple links. The multiple first paths may be determined based on the first routing metric. The determining the second path may include selecting path segments for the second path along the multiple links based on the path segments being included in the multiple first paths based on the second routing metric of the multiple links included in the path segments.