Patents by Inventor Qizhan LIN

Qizhan LIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation method of new-type nanoparticles for loading emodin
    Patent number: 10421852
    Abstract: The invention relates to a preparation method of new-type nanoparticles for loading emodin, which comprises: using L.A, mPEG and stannous iso caprylate to synthesize a first intermediate product; using the first intermediate product, butanedioic anhydride and 4-dimethylaminopyridine to synthesize a second intermediate product; using the second intermediate product, 1-ethyl-(3-dimethylamino propyl) carbodiimide hydrochloride, N-hydroxysuccinimide and chitosan to synthesize a third intermediate product; using the third intermediate product and sodium periodate to synthesize a fourth intermediate product; using the fourth intermediate product and 5-amino-2-mercapto benzimidazole to synthesize the new-type thiolated nanoparticles. The nanoparticles loaded with emodin are used for intestinal tract dose, which may enhance the nanoparticles' adhesion ability, prolong residence time of drugs on mucosal membranes, and facilitate sustained-release of drug molecules.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: September 24, 2019
    Assignee: GUANGDONG PROVINCIAL HOSPITAL OF TCM
    Inventors: Xusheng Liu, Qizhan Lin, Chuan Zou, Fuhua Lu, Zhaoyu Lu, Xiuqing Wu, Yuchi Wu, Chunlan Ji
  • PREPARATION METHOD OF NEW-TYPE NANOPARTICLES FOR LOADING EMODIN
    Publication number: 20180258257
    Abstract: The invention relates to a preparation method of new-type nanoparticles for loading emodin, which comprises: using L.A, mPEG and stannous iso caprylate to synthesize a first intermediate product; using the first intermediate product, butanedioic anhydride and 4-dimethylaminopyridine to synthesize a second intermediate product; using the second intermediate product, 1-ethyl-(3-dimethylamino propyl) carbodiimide hydrochloride, N-hydroxysuccinimide and chitosan to synthesize a third intermediate product; using the third intermediate product and sodium periodate to synthesize a fourth intermediate product; using the fourth intermediate product and 5-amino-2-mercapto benzimidazole to synthesize the new-type thiolated nanoparticles. The nanoparticles loaded with emodin are used for intestinal tract dose, which may enhance the nanoparticles' adhesion ability, prolong residence time of drugs on mucosal membranes, and facilitate sustained-release of drug molecules.
    Type: Application
    Filed: November 16, 2017
    Publication date: September 13, 2018
    Inventors: Chuan ZOU, Zhaoyu LU, Yuchi WU, Xusheng LIU, Qizhan LIN, Fuhua LU, Xiuqing WU