Abstract: Disclosed are antibodies thereof that bind to coagulation factor XI (FXI) and/or its activated form factor XIa (FXIa), or to fragments of FXI and/or FXIa, and compositions containing the antibodies. Also disclosed are methods of preparing the antibodies and use of the antibodies for treating and/or preventing coagulation associated conditions such as thrombosis and complications or conditions associated with thrombosis.

Abstract: The invention discloses a monoclonal antibody against human GPR48 and application of the same. In the antibody provided by the present invention, the amino acid sequences of LCDR1, LCDR2, and LCDR3 in the light chain variable region are shown in positions 27-32, 50-52, and 89-97 of SEQ ID No.1 sequentially, and the amino acid sequences of HCDR1, HCDR2 and HCDR3 in the heavy chain variable region are shown in positions 26-33, 51-60 and 99-108 of SEQ ID No.2 sequentially. The antibody has strong specificity and sensitivity to GPR48 protein, and can be applied to immunological experimental techniques such as western blotting, immunofluorescence and immunohistochemistry; it can be applied to flow cytometry experimental techniques such as flow cyometry analysis and flow cytometry sorting; it can be applied to the scientific research of signaling pathways such as subcellular localization and protein interaction.

Abstract: This document describes systems and techniques for a current-limiting control strategy for single-loop droop-controlled grid-forming inverters. In aspects, a hysteresis module is configured to compare an output current detected across one or more transistors in an inverter controlled by the single-loop droop converter with a specified maximum current and to generate an overcurrent signal. The overcurrent signal presents a fault signal responsive to the output current exceeding the specified maximum current. A logic array is configured to logically combine gate control signals generated by the single-loop droop controller to selectively direct the one or more transistors to allow the output current to flow therethrough with the overcurrent signal to present modified gate control signals to the one or more transistors.

Abstract: Provided herein are inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use for inhibiting DNA methyltransferase 1. The invention relates to compounds, pharmaceutical compositions, and methods for inhibiting DNA methyltransferase 1.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: Inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use as therapeutic agents against various cancers. The invention relates to compounds, pharmaceutical compositions, methods for inhibiting DNA methyltransferase 1, and methods for treating cancer. The inhibitors are compounds of the general formula.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodified nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.

Abstract: The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodifide nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.

Abstract: A bezel mounting assembly includes a bezel (10), a front panel (30) defining a pair of apertures (31), and a locking device (20) attached to the bezel for securing the bezel to the front panel. The bezel includes a pair of pillars (121) and a pair of blocks (11) having a pair of posts (14). The locking device includes a pair of symmetric side plates (22) defining through slots (25) for slidably receiving the posts, a pair of resilient arms (27) extending from the side plates, an operating member (23), and a pair of catches (26). The locking device is slidably attached on the blocks, with the posts engagingly received in the through slots. The resilient arms are secured to the pillars at free ends thereof. The operating member is moved vertically so as to drive the catches to engage in and disengage from the apertures of the front panel.

Abstract: An enhanced operating environment for an Interactive Real-Time Distributed Navigation system is disclosed. In the present invention, an enhanced operating environment is provided by improving input and output techniques in a navigation system. Disclosed are methods for reducing the number of inputs to a navigational sytstem through a wireless device. Improved input methods include methods for entering non-deterministic information to retrieve deterministic information. Also disclosed are improved output techniques including methods for pacing navigational prompts provided by a navigation system. The invention is applicable to text, graphics or audible navigation systems.

Abstract: A method and system for interactive real-time distributed navigation employs improved techniques for input and output. The method and system may receive inputs through a wireless device. The operating environment simplifies and reduces these inputs. In some embodiments, the system receives non-deterministic input to generate deterministic information using a number of methods. The system may also employ improved output techniques including methods for pacing navigational prompts provided by a navigation system, and methods of providing navigational information to a number of users. The method and system are applicable to text, graphics or audible navigation systems.