Abstract: Methods and systems are presented for signed document image analysis and fraud detection. An image of a document may be received from a user's device. A first layer of a machine learning engine is used to identify a signature and a name of the user within different areas of the received image. A second layer of the machine learning engine is used to extract a plurality of features from the different areas of the image. The plurality of features includes at least one visual feature representing the signature and at least one textual feature representing the name. A combined feature representation of the signature and the name is generated based on the plurality of features extracted from the image. A third layer of the machine learning engine is used to determine whether the signature of the user has been digitally altered, based on the combined feature representation.

Abstract: An electronic device and a method for detecting an intensity of ambient light are provided. The method includes: sensing a light intensity of incident light, wherein the incident light includes ambient light passed through the display screen and light leaked from the display screen; obtaining an estimated light intensity of the light leaked from the display screen based on display data of a target region of the display screen; computing based on the estimated light intensity and a temperature compensation coefficient corresponding to a current temperature of the display screen, to obtain a light intensity of the light leaked from the display screen; and obtaining a light intensity of the ambient light passed through the display screen based on the light intensity of the incident light and the light intensity of the light leaked from the display screen.

Abstract: The invention relates to methods of enriching for target nucleic acid molecules, More particularly, the methods of enriching for target nucleic acid molecules comprise binding target nucleic acid molecules in a sample with one or more first target endonucleases that are specific to a first locus of a target region of the target nucleic acid molecules, separating the target nucleic acid molecules from nontarget nucleic acid molecules in the sample, and binding the separated target nucleic acid molecules with one or more second target endonucleases that are specific to a second locus of the target region of the target nucleic acid molecules, and uses thereof.

Abstract: The present invention provides a porous tricalcium phosphate material, modified from a coral bone and having a plurality of pores, wherein the average compressive strength of the porous tricalcium phosphate material is 4 kgf to 9 kgf. Besides, the present invention also provides a method for bone healing and a manufacturing method for the porous tricalcium phosphate material. The porous tricalcium phosphate material of the present invention has the advantages of biocompatibility and no immunological rejection response, and also has significantly better mechanical properties and bone healing efficacy so as to better meet the needs of the patients.

Abstract: The present disclosure provides primers, primer sets, kits and methods for multiple displacement amplification, especially in combination with nucleic acid sequencing. The primers comprise self-complementary sequences at their 5? termini and random or semi-random sequences at their 3? termini. Use of such primers facilitates handling of multiple samples, increases sequence coverage uniformity, and improves sequencing error corrections.

Abstract: The present disclosure provides primers, primer sets, kits and methods for multiple displacement amplification, especially in combination with nucleic acid sequencing. The primers comprise self-complementary sequences at their 5? termini and random or semi-random sequences at their 3? termini. Use of such primers facilitates handling of multiple samples, increases sequence coverage uniformity, and improves sequencing error corrections.

Abstract: The invention relates to methods of detecting analytes in samples by generating analyte-based DNA libraries amenable for sequencing. The methods include the use of proximity probe pairs, each probe comprising an analyte binding domain and oligonucleotide domain. The methods further provide for integrated DNA and RNA library preparations and methods of making and uses thereof. The invention also provides compositions useful in the methods.

Abstract: The present disclosure provides methods and kits for highly multiplex single primer extensions using a MutS protein and Mg2+ at a concentration higher than that in a typical PCR reaction. Also disclosed is the use of such methods and kits in next generation sequencing.

Abstract: A cathode of a lithium-air battery includes a carbon nanotube composite film and a protecting layer. The carbon nanotube composite film includes a carbon nanotube network structure and a catalyst in particle form located in the carbon nanotube network structure. The carbon nanotube composite film is disposed on a surface of the protecting layer. The protecting layer allows conduction of lithium ions while preventing organic substances in an electrolyte of the lithium-air battery reaching the carbon nanotube composite film. A lithium-air battery is also disclosed.

Abstract: The present disclosure provides methods and kits for highly multiplex single primer extensions using a MutS protein and Mg2+ at a concentration higher than that in a typical PCR reaction. Also disclosed is the use of such methods and kits in next generation sequencing.

Abstract: The invention relates to integrated DNA and RNA library preparations and methods of making and uses thereof, wherein the DNA molecules are labelled with a tag identifying the molecule as being a DNA molecule and the RNA molecules are labelled with a tag identifying the molecule as being a RNA molecule. The methods do not require physical separation of DNA and RNA. The methods output two separate libraries from DNA and RNA, respectively, which helps flexible manipulation on downstream sequencing platforms. The application also claims the DNA library and the cDNA library produced by the method and the DNA tag and the RNA tag used in the method.

Abstract: The present disclosure provides methods and kits for performing high multiplex PCR using molecular barcodes. The methods disclosed herein separately extend a set of primers (BC primers) that each comprise a molecular barcode and a target-specific sequence, and amplify the resulting extension products using another set of primers (LA primers) that each comprise another target-specific sequence. Such methods avoid barcode resampling and suppress primer dimers in traditional high multiplex PCR.

Abstract: The present disclosure provides methods and kits for performing high multiplex PCR using molecular barcodes. The methods disclosed herein separately extend a set of primers (BC primers) that each comprise a target-specific sequence, a molecular barcode and a universal sequence, and amplify the resulting extension products using another set of primers (LA primers) that each comprise another target-specific sequence and a universal sequence. The methods may further comprise amplification using universal primers (preferably comprising an adapter).

Abstract: The present disclosure provides methods, arrays and kits for assessing the quality of genomic DNA samples, especially those obtained from formalin-fixed paraffin-embedded (FFPE) samples. The methods, arrays and kits provided herein use primer pairs specific to regions in the genomes of the organisms from which genomic DNA samples are obtained that have identical or nearly identical copies distributed across multiple chromosomes.

Abstract: The present disclosure provides methods, arrays and kits for assessing the quality of genomic DNA samples, especially those obtained from formalin-fixed paraffin-embedded (FFPE) samples. The methods, arrays and kits provided herein use primer pairs specific to regions in the genomes of the organisms from which genomic DNA samples are obtained that have identical or nearly identical copies distributed across multiple chromosomes.

Abstract: The present disclosure provides methods, arrays and kits for assessing the quality of genomic DNA samples, especially those obtained from formalin-fixed paraffin-embedded (FFPE) samples. The methods, arrays and kits provided herein use primer pairs specific to regions in the genomes of the organisms from which genomic DNA samples are obtained that have identical or nearly identical copies distributed across multiple chromosomes.

Abstract: This invention refers to a tight-fitting full-face mask for respiratory protection, which can provide a much larger look-down field of vision as a new model. It can be applied to industrial compressed air respirator with a self-contained open circuit, positive-pressure firefighting respirator, oxygen respirator, gas mask, and middle-pressure tube respirator. This has helped to address the problems that existing wide-field full-face masks can only provide a small field of vision and users cannot observe surrounding environments well with it. Besides breaking through traditional structure of existing wide-field full-face masks, this application reduces interface area in the middle of the bottom and moves it downwards to the greatest extent. The distance H is designed to be 137 mm-170 mm (except transitions) and distance L to 65 mm-98 mm for the purpose of obtaining a brand-new model.

Abstract: This invention refers to a positive-pressure air respirator carrying tool for the air cylinder holder with a built-in decompressor in the technical field of backboard parts of positive-pressure air respirator. It breaks through the traditional structure that decompressor tends to be fixed with air respirator at the outside bottom of the backboard. The original design can be easily polluted, corroded, or damaged by hard objects, and there is a hard connection between decompressor and air cylinder valve. This application installing the decompressor within the air cylinder holder of the backboard makes use of the space inside air cylinder holder skillfully, with decompressor cover plate on air cylinder holder. As for the compressed air in the air cylinder, the air cylinder is connected with decompressor via soft tube. In this way, the decompressor will be protected and other functions will not be impaired so that the safety of decompressor can be assured.

Abstract: The present disclosure provides primers, primer sets, kits and methods for multiple displacement amplification, especially in combination with nucleic acid sequencing. The primers comprise self-complementary sequences at their 5? termini and random or semi-random sequences at their 3? termini. Use of such primers facilitates handling of multiple samples, increases sequence coverage uniformity, and improves sequencing error corrections.

Abstract: The present disclosure provides methods and kits for highly multiplex single primer extensions using a MutS protein and Mg2+ at a concentration higher than that in a typical PCR reaction. Also disclosed is the use of such methods and kits in next generation sequencing.