Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties.

Abstract: A magnetic tunneling junction (MTJ) device structure and the method of constructing such device are disclosed. Also disclosed are methods of using the device for spin-dependent transport characterization through biomolecules for structure and dynamic function analysis in physiological environments.

Abstract: The present disclosure provides chips, devices and methods for sequencing a biomolecule. The biomolecule may be DNA, RNA. a protein, or a peptide. The chip comprises a substrate; a first and second fluid chamber; fluid channels connecting the first and second fluid chamber; a first and second electrode disposed on opposing sides of the central fluid channel and having a nanogap therebetween, wherein the width of the nanogap is modulated by confined electrochemical deposition; and a passivation layer disposed on top of the first and second electrodes and the fluid channel.

Abstract: A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising a top surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

Abstract: The present disclosure provides devices, systems, and methods related to protein bioelectronics. In particular, the present disclosure provides bioelectronic devices, systems, and methods that utilize a defined electrical potential to maximize electrical conductance of a protein-of-interest, which can serve as a basis for the fabrication of enhanced bioelectronic devices for the direct measurement of protein activity.

Abstract: The present disclosure provides a method and an apparatus for searching a cartoon. The method includes: S1, receiving query information input by a user; S2, acquiring cartoon information related to the query information; and S3, providing a searching result page, and displaying the cartoon information in the searching result page in a preset form. With the method and apparatus provided by the present disclosure, the user may browse relevant cartoons through searching without needing to search and browse on the social network or click the natural result to enter a website for browsing, thereby better satisfying the user's cartoon searching requirement.

Abstract: Implantable thin-films have a variety of uses but due to their geometry and size, they are extremely fragile. The present disclosure presents devices and apparatuses for implantable thin-film probes capable of maintaining their thin-film structure through implantation through the use of degradable sacrificial layers to plant or deposit a thin film structure via a rigid substrate and remove the rigid substrate once the sacrificial layer has dissolved. The disclosed structures and methods are in reference to biocompatible films for use in vivo, but other environments and uses may also benefit from the disclosed structures and techniques, such as prosthetic/assistive devices, chronic deep tissue electrical stimulation, electrical field-directed cell migration for wound healing, nerve/neuron rehabilitation, etc.

Abstract: A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.

Abstract: The present disclosure provides chips, devices and methods for sequencing a biomolecule. The biomolecule may be DNA, RNA. a protein, or a peptide. The chip comprises a substrate; a first and second fluid chamber; fluid channels connecting the first and second fluid chamber; a first and second electrode disposed on opposing sides of the central fluid channel and having a nanogap therebetween, wherein the width of the nanogap is modulated by confined electrochemical deposition; and a passivation layer disposed on top of the first and second electrodes and the fluid channel.

Abstract: The present disclosure provides a method and an apparatus for searching a cartoon. The method includes: S1, receiving query information input by a user; S2, acquiring cartoon information related to the query information; and S3, providing a searching result page, and displaying the cartoon information in the searching result page in a preset form. With the method and apparatus provided by the present disclosure, the user may browse relevant cartoons through searching without needing to search and browse on the social network or click the natural result to enter a website for browsing, thereby better satisfying the user's cartoon searching requirement.

Abstract: The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells.

Abstract: The present invention generally relates to nanoscale devices and methods, including bent nanowires and other bent nanoscale objects, and in particular, the ability to probe cells with nanoscale objects. In some aspects, nanoscale objects, including nanowires, are provided that facilitate cell probing, e.g. nanowires that are surface modified such that cells can fuse with the nanowires. Devices including nanoscale objects are provided that allow small or large scale (e.g., multiplexed) probing of cells, and related methods of making such nanoscale objects and devices, and methods of investigating cells, are provided by certain embodiments of the invention. In a related set of embodiments, the present invention is generally related to bent nanowires and other bent nanoscale objects. For instance, in one aspect, the present invention is generally related to a semiconductor nanoscale wire having at least one kink. The semiconductor nanoscale wire may be formed out of any suitable semiconductor, e.g.

Abstract: Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.

Abstract: The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells.

Abstract: Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.

Abstract: A power supply configured for converting an input AC voltage into an output DC voltage having a desired voltage level is provided. The power supply includes a front-end power converter such as a PFC converter which is configured to convert the input AC voltage into an intermediate DC voltage generated across an output capacitive unit, and a back-end power converter such as a DC-DC converter which is configured to convert the intermediate DC voltage into an output DC voltage having a desired voltage level. The power supply further includes a resonant network consisted of a filter which is made up of at least one inductive filtering element having an inductive impedance and a capacitive filtering element having a capacitive impedance. The resonant network is placed between the front-end power converter and the back-end power converter, and coupled with the output capacitive unit for filtering the current flowing into the output capacitive unit.