Abstract: Described herein are monopolar treatment delivery systems, and methods for use therewith. Such a system can include an energy delivery electrode, a dispersive electrode, a reference electrode, and a generator in electrical communication with the energy delivery electrode, the dispersive electrode, and the reference electrode. The generator is configured to deliver an impedance measurement signal to target tissue using the energy delivery electrode and the dispersive electrode, while the energy delivery electrode is proximate to the target tissue and the dispersive electrode is remote from the target tissue. The generator is also configured to measure a voltage between the energy delivery electrode and the reference electrode, and to monitor impedance of the target tissue based on a current of the impedance measurement signal and the voltage between the energy delivery electrode and the reference electrode. The monitored impedance can be used, e.g., to deduce a treatment effect outcome.

Abstract: Devices, systems and methods are provided for delivering molecules, particularly small molecules and/or macromolecules, to cells within the body, particularly to target cells which directly therapeutically benefit from the functionality of the molecules. Example molecules include DNA plasmids, RNAs (e.g. messenger RNA (mRNA), small interfering RNA (siRNA), micro RNA), oligonucleotides, antisense oligonucleotides (ASO), proteins and/or materials which invoke genetic or epigenetic changes in the cellular behavior, to name a few. In such instances, the molecules are driven into the target cells with the use of pulsed electric fields (PEFs) which deliver the molecules through the cell wall of the target cells so that the desired genes are able to carry out the desired effect within the cells. Thus, the molecules are to be delivered to the desired location within the body at a desired time and in a desired concentration relative to the delivery of the pulsed electric fields for optimal outcomes.

Abstract: Tissue treatment systems and methods are disclosed. In an embodiment, a tissue treatment system includes a LV signal generator, a HV signal generator, and a controller. The LV signal generator is used to produce a LV tissue impedance measurement signal, and the HV signal generator is used to produce a HV tissue treatment signal having a voltage that is at least five times greater than a voltage of the LV tissue impedance measurement signal. The controller controls when the HV tissue treatment signal produced using the HV signal generator, and when the LV tissue impedance measurement signal produced using the LV signal generator, are delivered to patient tissue via an active electrode and a return electrode. The LV tissue impedance measurement signal is used to estimate the impedance of the patient tissue, which is used to control the voltage and/or current of the HV tissue treatment signal.

Abstract: Devices, systems and methods are provided for delivering pulsed electric field (PEF) energy to tissue through one or more energy delivery bodies, each having one or more electrodes. The PEF energy is generated from a waveform having a variety of features. Waveform delays, such as inter-pulse delays, inter-cycle delays, inter-phase delays, inter-packet delays, inter-bundle delays, may be utilized within a treatment to obtain a desired outcome. In particular, these delays may be specifically manipulated to obtain particular desired outcomes. For example, one, some or all of these delays may be manipulated to control various aspects of PEF therapy so as to mitigate any associated risks, such as gas formation, electrical discharge, cavity formation, muscle contraction, and temperature rise, to name a few. In some embodiments, the delays distribute the period over which PEF energy is delivered, resulting in marked changes and optimization to the treatment delivery outcomes.

Abstract: Damaged, diseased, abnormal, obstructive, cancerous or undesired neural tissue treated by delivering specialized pulsed electric field (PEF) energy to target tissue areas. In some instances, the target tissue includes a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue. Most brain and spinal cord tumors develop from glial cells. These tumors are sometimes referred to as a group called gliomas. They arise from the supporting cells of the brain, called the glia. These cells are subdivided into astrocytes, ependymal cells and oligodendroglial cells (or oligos). One difficulty in the treatment of gliomas is that they are behind the blood-brain barrier (BBB) and blood-tumor barrier (BTB) which leads to poor delivery of anti-cancer drugs or immune agents to the tumor-infiltrated brain.

Abstract: The invention refers to an implantable sensing system comprising an electronic implant and a reading unit to obtain measurements originating at the implant or its surroundings to characterize physical and/or chemical clinical parameters of a living body. The electronic implant comprises an electronic circuit and at least two electrodes connected to the electronic circuit. The electronic circuit comprises a capacitor and a device of asymmetric conductance capable of rectifying an alternating current, both connected in series between two electrodes. An electronic component is connected in parallel with the device of asymmetric conductance, for the capacitor discharge. The capacitor, the device of asymmetric conductance and/or the electronic component, can be a transducer selected such as an operational parameter of the transducer is variable depending on a physical and/or chemical condition of a medium of a living body.

Abstract: Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue.

Abstract: Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) by delivering specialized pulsed electric field (PEF) energy to target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing thermal ablation). Consequently, when extracellular matrices present, the extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to target tissue throughout the body, particularly in locations previously considered inaccessible to percutaneous approaches.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: Devices, systems and methods are provided for treating conditions of the heart, particularly the occurrence of arrhythmias. The devices, systems and methods deliver therapeutic energy to portions the heart to provide tissue modification, such as to the entrances to the pulmonary veins in the treatment of atrial fibrillation. Generally, the tissue modification systems include a specialized catheter, a high voltage waveform generator and at least one distinct energy delivery algorithm. Other embodiments include conventional ablation catheters and system components to enable use with a high voltage waveform generator. Example catheter designs include a variety of delivery types including focal delivery, “one-shot” delivery and various possible combinations. In some embodiments, energy is delivered in a monopolar fashion. However, it may be appreciated that a variety of other embodiments are also provided.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: The invention relates to a system for preventing bacterial infections in needle trajectories, comprising: a percutaneous surgical instrument (1) percutaneously introducible into a tissue (3) of a patient, such as a biopsy needle, and having an outer surface made of an electrically conductive material; a contact electrode (4) applicable to the skin (3a) of a patient; a silver coating or element (P) arranged on or forming part of the instrument (1), and configured, sized and provided so as to break down by means of electrochemical release when a current is applied thereto, releasing silver ions into its surroundings; and an electric current generator (2) arranged and configured for generating a current and inducing the temporary circulation thereof between the instrument (1) acting as an anode, the tissue (3) and the contact electrode (4) acting as a cathode, respectively, with a specific magnitude and duration for producing a massive and sudden release of silver ions for the purpose of preventing pos

Abstract: System for preventing bacterial infections in needle trajectories. The system includes a percutaneous surgical instrument (1) percutaneously introducible into a patient's tissue (3) such as a biopsy needle, and having an outer surface made of an electrically conductive material; a contact electrode (4) applicable to the patient's skin (3a); a silver coating or element (P) arranged on or forming part of the instrument (1) to break down by electrochemical release when a current is applied thereto, releasing silver ions into its surroundings; and an electric current generator (2) arranged and configured for generating a current and inducing the temporary circulation thereof between the instrument (1) acting as an anode, the tissue (3) and the contact electrode (4) acting as a cathode, respectively, with a specific magnitude and duration for producing a massive and sudden release of silver ions for the purpose of preventing post-treatment bacterial infections.

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Abstract: System for preventing bacterial infections in needle trajectories. The system includes a percutaneous surgical instrument (1) percutaneously introducible into a patient's tissue (3) such as a biopsy needle, and having an outer surface made of an electrically conductive material; a contact electrode (4) applicable to the patient's skin (3a); a silver coating or element (P) arranged on or forming part of the instrument (1) to break down by electrochemical release when a current is applied thereto, releasing silver ions into its surroundings; and an electric current generator (2) arranged and configured for generating a current and inducing the temporary circulation thereof between the instrument (1) acting as an anode, the tissue (3) and the contact electrode (4) acting as a cathode, respectively, with a specific magnitude and duration for producing a massive and sudden release of silver ions for the purpose of preventing post-treatment bacterial infections.