Abstract: Methods and compositions for providing a cytotoxic effect against FOLR-1 expressing cancers using antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs are provided. Examples of FOLR-1 expressing cancers include leukemias, ovarian cancer, breast cancer, bladder cancer, and lung cancer, among other cancers described herein.

Abstract: In various embodiments, the present disclosure provides chimeric antigen receptors (CARs) which bind to mesothelin. The mesothelin CARs comprise an extracellular region comprising a binding domain that specifically binds to at least a portion of mesothelin, a transmembrane region, and an intracellular region comprising an effector domain or a portion or variant thereof and a costimulatory domain or a portion or variant thereof. Recombinant host cells expressing the mesothelin CARs are also provided, as well as compositions and methods of treatment, prevention, and manufacture comprising the same.

Abstract: An Automated Analysis and Warning of Optical Transmission (AWOT) between BBU unit and RRU of radio transmitting station accurately and quickly identifies errors on an optical transmission line, thereby reducing costs in terms of labor and equipment, and at the same time reducing service downtime of mobile communication systems.

Abstract: An Automated Analysis and Warning of Optical Transmission (AWOT) between BBU unit and RRU of radio transmitting station accurately and quickly identifies errors on an optical transmission line, thereby reducing costs in terms of labor and equipment, and at the same time reducing service downtime of mobile communication systems.

Abstract: An apparatus is provided including a shaft, wherein the shaft is stationary. A rotatable component is configured to rotate with respect to the shaft. A fluid is operable to flow between the shaft and the rotatable component. A limiter is at a first axial end of the shaft, and a cup is at a second axial end of the shaft. An axially extending grooved region is between the limiter and the rotatable component.

Abstract: The present invention is directed to an embossing tool having a microstructure on its surface wherein the surface of the embossing tool has a thin layer of gold or an alloy thereof. Such an embossing tool not only can reduce adhesion between the surface of the embossing tool and a cured material, but also does not cause any significant change to the profile of the microstructure.

Abstract: Provided herein is an apparatus, including a stationary component, a rotatable component configured to rotate relative to the stationary component, and a conical pumping seal formed between the stationary component and the rotatable component.

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: The present invention relates generally to mutagenesis of target genes that enhances the natural mutagenic capabilities of adaptive immune cells by providing a chimeric construct that exploits the ability of molecules such as AID to stimulate diversification and the ability of a second molecule to restrict nuclear activity of the molecules and/or protect cell viability. The invention provides a method for stimulating diversification in expressed genes, such as antibody genes, using polypeptides whose nuclear activity is restricted to specific phases of the cell cycle. This method can be coupled with selection to identify B cell clones that produce, for example, antibodies of high affinity or specificity, or for developing T cells for immunotherapy. The invention provides an improved means of developing a repertoire of variant immunoglobulins and other polypeptides.

Abstract: A device including a first axial portion, a second axial portion, and a radial portion is disclosed. A portion of the second axial portion is configured to connect to a hub. An upper surface of the second axial portion may be positioned above an upper surface of a sleeve limiter shoulder when the portion of the second axial portion is connected to the hub. The radial portion connects the first axial portion to the second axial portion. The radial portion is configured to increase stiffness by increasing surface contact between the radial portion and the sleeve limiter shoulder.

Abstract: A sealing gasket sheet and a storage drive are provided. The sealing gasket sheet includes a first adhesive layer, a metal layer disposed adjacent to the first adhesive layer, and a second adhesive layer disposed adjacent to the metal layer. The storage drive includes an enclosure formed by a storage drive base and a cover with the sealing gasket sheet between the storage drive base and the cover.

Abstract: A storage base having an interior side and an exterior side is described. The storage drive base includes a slotted aperature, a flexible circuit and a sealing-adhesive barrier. The slotted aperature passes through the storage drive base from the interior side to the exterior side. The flexible circuit has a first end and a second end. The first end of the flexible circuit is installed in the slotted aperture and aligned so that the first end extends along an interior surface of the storage drive base in a location proximal to the slotted aperture. The sealing-adhesive barrier is applied between edges of the slotted aperture and the flexible circuit to form a hermetic seal between the exterior side and the interior side of the storage drive base.

Abstract: An apparatus is provided including a shaft, wherein the shaft is stationary. A rotatable component is configured to rotate with respect to the shaft. A fluid is operable to flow between the shaft and the rotatable component. A limiter is at a first axial end of the shaft, and a cup is at a second axial end of the shaft. An axially extending grooved region is between the limiter and the rotatable component.

Abstract: An apparatus and method are provided for a robust and shock resistant fluid dynamic bearing. A fluid sealing system with fluid pumping and capillary features provides increased reliability and performance for small form factor disc drive memory systems. Concerns of motor jog are addressed, jog being the rapid and repeated opening and closing of spaces between relatively rotatable components that can dispel oil from, or draw air into, these spaces. The fluid pumping capillary sealing system includes a fluid pumping groove with a rib portion and a slot portion for pumping fluid. The fluid pumping capillary sealing system also includes a capillary seal. In an aspect, a sweeping rib sweeps fluid toward the bearing. A truncated rib is situated adjacent to the sweeping rib, the truncated rib extending a shorter radial distance as compared to the sweeping rib and forming a plenum region.

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Provided herein is an apparatus, including a stationary component; a rotatable component; a fluid dynamic bearing defined by the stationary component and the rotatable component; a first channel substantially parallel to the fluid dynamic bearing; a second channel substantially perpendicular to the first channel; and a fluid reservoir substantially parallel to the first channel, wherein the second channel fluidly connects the fluid reservoir to the first channel.

Abstract: Provided herein is an apparatus that includes a radially extending through hole in an interperimeteral region and a radial channel extending from the through hole to an inner perimeter of an annulus. The radially extending through hole and the radial channel define a compliant flange operable to engage an annular groove. In some embodiments, the apparatus may be used as a screwless disk clamp in a hard disk drive.

Abstract: The present invention is directed to an embossing tool having a microstructure on its surface wherein the surfaces of the microstructures are overcoated with a precious metal or an alloy thereof. Such an embossing tool not only can reduce adhesion between the surface of the embossing tool and a cured material, but also does not cause any significant change to the profile of the microstructure.

Abstract: The present invention is directed to an embossing tool having a microstructure on its surface wherein the surface of the embossing tool has a thin layer of gold or an alloy thereof. Such an embossing tool not only can reduce adhesion between the surface of the embossing tool and a cured material, but also does not cause any significant change to the profile of the microstructure.

Abstract: Provided herein is an apparatus, including a stator assembly and a hub configured to rotate relative to the stator assembly. The hub comprises a magnet radially outside the stator assembly. The apparatus further includes a fastener coupling radially inside the stator assembly.