Abstract: The present disclosure provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject.

Abstract: Operating a PNP double-sided double-base bipolar junction transistor (DSDB BJT). One example is a method of operating a DSDB-BJT, the method comprising: conducting a first load current from an upper terminal of the power module to an upper base of the transistor, through the transistor, and from a lower base to a lower terminal of the power module; and then responsive assertion of a first interrupt signal interrupting the first load current from the lower base to the lower terminal by opening a lower-main FET and commutating a first shutoff current through a lower collector-emitter of the transistor to the lower terminal; and blocking current from the upper terminal to the lower terminal by the transistor.

Abstract: A processing system may include a plasma chamber operable to generate a plasma, and an extraction assembly, arranged along a side of the plasma chamber. The extraction assembly may include an extraction plate including an extraction aperture, the extraction plate having a non-planar shape, and generating an extracted ion beam at a high angle of incidence with respect to a perpendicular to a plane of a substrate, when the plane of the substrate is arranged parallel to the side of the plasma chamber.

Abstract: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.

Abstract: A method of isotope-labelling a microbiota sample. It involves providing a first microbiota sample that was obtained from a given source; exposing the first microbiota sample to an isotope enriched medium; and culturing the exposed first microbiota sample in the isotope enriched medium to obtain an isotope-labelled microbiota sample, wherein the isotope labelled metaproteome of the isotope-labelled microbiota sample is taxon specific for taxa present in the first microbiota sample when initially obtained from the given source.

Abstract: Systems, methods, and devices for converting electric power are disclosed. Converter modules convert power in a configurable manner in conjunction with a controller.

Abstract: A digital imaging system is provided with direct view of an object, having: an optical element configured to allow visible light to pass therethrough to a user's eye and to redirect light of non-visible wavelengths away from the user's eye; a display disposed between the user's eye and the object; a digital camera mounted outside a field of view of the user's eye and configured to obtaining imaging data from the light of non-visible wavelength; a redirection optic disposed so as to redirect the light of non-visible wavelength to the digital camera; and an image processor configured to process the imaging data from the digital camera and output the data to the display such that an image generated from the imaging data from the digital camera overlays an image produced by the impingement of visible light on the user's eye following the visible light's passing through the optical element.

Abstract: A tool clip for attaching a power tool to an item worn by a user. The tool clip includes a first piece having inner and outer parts joined by a bend. The tool clip further includes a second piece having inner and outer parts joined by a bend. The second piece includes a release tab which passes through a slot in the first piece to engage the first and second pieces with each other. The first and second pieces each have a mounting hole such that a screw can be passed through the mounting holes and into an existing hole in the power tool.

Abstract: A digital imaging system is provided with direct view of an object, having: an optical element configured to allow visible light to pass therethrough to a user's eye and to redirect light of non-visible wavelengths away from the user's eye; a display disposed between the user's eye and the object; a digital camera mounted outside a field of view of the user's eye and configured to obtaining imaging data from the light of non-visible wavelength; a redirection optic disposed so as to redirect the light of non-visible wavelength to the digital camera; and an image processor configured to process the imaging data from the digital camera and output the data to the display such that an image generated from the imaging data from the digital camera overlays an image produced by the impingement of visible light on the user's eye following the visible light's passing through the optical element.

Abstract: A disaster response system includes a communication infrastructure including a plurality of sensor assemblies configured to generate data indicative of at least one of environmental conditions, motion, position, chemical detection, and medical information; and wirelessly provide the generated data to the communication infrastructure. The system also includes an incident command infrastructure configured to exchange data with the communication infrastructure; and detect an incident based on the data from the sensor assemblies. The system also includes an unmanned aerial vehicle (UAV) configured to deliver a payload in response to the detected incident.

Abstract: Disclosed are systems, including client devices and servers, and methods for creating a collaborative virtual session between client devices, wherein each of the client devices is associable with a coupler agent for interfacing with a communicating entity (such as a person). A client device includes a processor and memory operable to: generate a locally instantiated virtual room; instantiate a virtual representation of a first entity associated with the client device in the locally instantiated virtual room; transmit metadata representative of the first entity to a second client device; receive metadata representative of a second entity associated with the second client device; and, instantiate a virtual representation of the second entity as a function of the received metadata, from a perspective of the first entity, in the locally instantiated virtual room. A server can be utilized to join the client devices in the collaborative virtual session and exchange the metadata.

Abstract: An embodiment of a disaster response system is disclosed that includes a communication and monitoring environment (CME). The CME includes an incident command infrastructure, and a communication infrastructure configured to exchange data with the incident command infrastructure. The communication infrastructure includes a network comprising a plurality of sensor assemblies that are configured to wirelessly communicate with the communication infrastructure. The sensor assemblies are configured to acquire data that includes at least one of environmental conditions, motion, position, chemical detection, and medical information. One or more of the sensors are configured to aggregate data from a subset of the plurality of sensors. The CME is configured to detect an incident based on at least the data acquired by the sensor assemblies.

Abstract: A total ankle replacement prosthesis may comprise a tibial implant, a talar implant, and an intermediate implant. The intermediate implant may fixedly attach to the tibial implant and may articulate with respect to the talar implant. The intermediate implant may have unequal front and back angular extent, so as to discourage a particular direction of subluxation, and a kit may be provided containing various such intermediate implants. Various features may be provided in regard to dovetails, fins, recesses, the placement of fins and pegs, and the shape of the perimeter of the tibial implant. Recesses may allow a surgical blade to slice a latch off of an already-installed intermediate implant, in order to allow its removal from the tibial implant.

Abstract: Disclosed are systems, including client devices and servers, and methods for creating a collaborative virtual session between two or more client devices, wherein each of the client devices is associable with a coupler agent for interfacing with a communicating entity (such as a person).

Abstract: A total ankle replacement prosthesis may comprise a tibial implant, a talar implant, and an intermediate implant. The intermediate implant may fixedly attach to the tibial implant and may articulate with respect to the talar implant. The intermediate implant may have unequal front and back angular extent, so as to discourage a particular direction of subluxation, and a kit may be provided containing various such intermediate implants. Various features may be provided in regard to dovetails, fins, recesses, the placement of fins and pegs, and the shape of the perimeter of the tibial implant. Recesses may allow a surgical blade to slice a latch off of an already-installed intermediate implant, in order to allow its removal from the tibial implant.

Abstract: A cement-based tile formed from a mixture comprising: a cement in the range of about 0.1 to 88% by wet weight percent; a secondary material in the range of about 0.1 to 50% by wet weight percent, the secondary material comprising limestone, sand, silica sand, gypsum, silica fume, fumed silica, Plaster of Paris, calcium carbonate, fly ash, slag, rock, or a combination thereof; a reinforcement fiber in the range of about 0.5 to 20% by wet weight percent, the reinforcement fiber comprising cellulose fiber, glass fiber, plastic fiber, polypropylene fiber, polyvinyl alcohol (PVA) fiber, homopolymer acrylic fiber, alkali-resistant fiber, or a combination thereof; a rheology modifying agent in the range of about 0.5 to 10% by wet weight percent; a water in the range of 10 to 60% of a total wet material weight; and wherein the mixture is extruded or molded to form the cement-based tile.

Abstract: A lightweight thermal insulating cement-based material is formed from a mixture that includes cement, water and a foaming agent. The foaming agent can be an aluminum powder or a surfactant. The insulating material has a maximum use temperature of about 900 degrees Celsius or more.

Abstract: Disclosed are systems, including client devices and servers, and methods for creating a collaborative virtual session between two or more client devices, wherein each of the client devices is associable with a coupler agent for interfacing with a communicating entity (such as a person).

Abstract: A cement-based material is formed from a mixture that includes cement in the range of about 40 to 90% by wet weight percent, a lightweight expanded aggregate in the range of about 10 to 60% by wet weight percent, a secondary material in the range of about 0.1 to 50% by wet weight percent, a reinforcement fiber in the range of about 1 to 20% by wet weight percent, a rheology modifying agent in the range of about 0.5 to 10% by wet weight percent, a retarder in the range of about 0.1 to 8% by wet weight percent, and water in the range of 10 to 60% of a total wet material weight.

Abstract: An endoscope including an examination field cleaning system and a method of using the endoscope to clean an examination field in an internal body cavity are disclosed herein. The endoscope includes an inner channel that includes a primary working channel, lens system, and light delivery system and an outer secondary working channel that includes an examination field cleaning system. The inner channel is approximately cylindrical and is encompassed by a flexible tube. The outer secondary working channel is encompassed by an outer cylinder that is approximately concentric with and fully encompasses the inner channel and tube, where the examination field cleaning system may include one or more fluid delivery channels. The endoscope may further have an anchoring bridge that secures the outer cylinder to the inner channel.