Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a base, a first paddle, a second paddle, and a rack and pinion mechanism. The first paddle is pivotally connected to the base. The second paddle is pivotally connected to the base. The rack and pinion mechanism is coupled to the first paddle and the second paddle. The rack and pinion mechanism is configured to move the first paddle and the second paddle between an open position and a closed position.

Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a paddle, a gripping member, and an indicator. The paddle and/or the gripping member are movable to form an opening or capture region between the gripping member and the paddle. The indicator is configured to indicate whether a leaflet of the native valve is inserted into the opening or capture region between the paddle and the gripping member to at least a minimum insertion depth.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Systems and processes for operating an intelligent automated assistant are provided. In some embodiments, contextual data is obtained and used to select a set of keywords (e.g., words or phrases) for voice control of an electronic device. When a speech input is received by the electronic device, a determination is made whether the speech input includes any of the selected keywords. If the speech input does include a selected keyword, an action is performed in response.

Abstract: A valve repair system for repairing a native valve of a patient during a non-open-heart procedure includes a delivery device and a valve repair device. The valve repair device include a pair of paddles, first gripping member, a second gripping member, and a spacer. First and second gripping member controls or first and second gripping member control portions are coupled to the first and second gripping members to move the gripping members. The spacer element is configured to close a gap in the native valve of the patient when the valve repair device is attached to the native valve.

Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a compressible spacer element, a pair of paddles, and a pair of gripping members. The pair of paddles are coupled to the spacer element. The pair of gripping members are disposed between the pair of paddles. The paddles and the gripping members are configured to attach to leaflets of a heart valve.

Abstract: A nasal simulator includes a three-dimensional (3D) printed nasal cavity within based on diagnostic imagery of a human nasal cavity. The nasal simulator comprising a fan system positioned to mimic air flow through the human nasal cavity. A first probe access bore is formed through the 3D printed nasal cavity to a first location having a first internal contour. An anemometer insert having an outer diameter sized to be slidingly received in and to pneumatically seal the first probe access bore, the anemometer insert having a distal contour that aligns with the first internal contour of the 3D printed nasal cavity, the anemometer insert having a longitudinal bore that is sized to receive a probe of an anemometer to detect characteristics of the air flow through the 3D cavity.

Abstract: A fluid monitoring module includes an enclosure, a fluid sensing device assembled with the enclosure, and a controller disposed within the enclosure. The fluid sensing device includes a body member defining a fluid port external to the enclosure and a male threaded sensor port mounted to the enclosure and extending laterally into the enclosure, a female threaded nut assembled with the sensor port, a fluid sensor seated against a counterbore portion of the sensor port, and a retaining collar having a neck portion extending into the sensor port in engagement with the fluid sensor and a head portion captured between the female threaded nut and an end face of the sensor port. The controller is in circuit communication with the fluid sensor for receiving at least one of pressure indicating signals and temperature indicating signals from the fluid sensor, and for measuring fluid data based on the received signals.

Abstract: A method of cooling a battery cell includes: atomizing a cooling fluid by driving it through a micro-nozzle at a pressure sufficient to create a jet of aerosolized liquid droplets while retaining sufficient momentum in flow of the fluid to travel from the nozzle to an outer surface of the battery cell; impinging the spray of the jet of aerosolized liquid droplets on an outer surface of the battery cell; partially evaporating the liquid droplets on the outer surface to conduct heat from the outer surface; and convecting heat from the outer surface of the battery via the cooling fluid.

Abstract: A flow sensing device includes a first body member defining an inlet port, an upstream sensor port, and a first connecting port; a second body member defining an outlet port, a downstream sensor port, and a second connecting port; a flow restricting element defining a flow restricting passage and including a first end connection coupled to the first connecting port and a second end connection coupled to the second connecting port, such that the flow restricting passage is disposed between the inlet port and the outlet port, and between the upstream sensor port and the downstream sensor port; a first fluid sensor assembled with the upstream sensor port; and a second fluid sensor assembled with the downstream sensor port.

Abstract: A magnet includes a stack of a plurality of superconducting pancake wound coils having a stacking axis normal to a winding direction of the coils. The stack has axial ends and has a stack midplane relative to the stacking axis. A quench detector is provided for detecting a quench in the stack of superconducting pancake wound coils. A plurality of resistance quench heaters (RQH) are distributed symmetrically along the axis with respect to the stack midplane. Control circuitry is provided for controlling the operation of the RQH upon the detection of a quench by the quench detector. A method of quenching a magnet is also disclosed.

Abstract: Coils for superconducting magnets and methods of making coils for superconducting magnets and controlling the turn-to-turn contact resistance of coils. The coils include a REBCO superconducting tape coated with a layer of tin-lead solder, co-wound with an oxidized stainless steel tape. The inclusion of tin-lead solder on the REBCO tape and a layer of oxidation on the stainless steel tape advantageously allow for tuning of the turn-to-turn contact resistance of the coil, and advantageously mitigates the effect of repeated pressure cycling on the turn-to-turn contact resistance.

Abstract: A system for implanting a repair device onto a native valve of a natural heart to repair the native valve of a patient during a non-open-heart procedure. The system includes a base assembly, a pair of paddles, and a pair of gripping members. The base assembly includes a shaft and a coupler attached to the shaft such that the coupler can be moved along the shaft. The paddles are movable between an open position, a closed position and a bailout position. The paddles and the gripping members are configured to attach to the native valve of the patient. Movement of the coupler along the shaft causes the paddles to move between the open position, the closed position, and the bailout position. When the paddles are in the bailout position, a bailout angle between each paddle of the pair of paddles and the shaft is greater than or equal to 120 degrees.

Abstract: A flow control device includes a body and a flow control element. The body includes a thermal conditioning passage disposed within a side wall, disconnected from a flow passage, and extending between a first conditioning port and a second conditioning port. The thermal conditioning passage has a first portion extending circumferentially around a first circumferential portion of the interior surface of the flow passage, a second portion axially spaced from the first portion by a first axial U-shaped bend and extending circumferentially around the first circumferential portion and a second circumferential portion of the interior surface of the flow passage to form a first circumferential U-shaped bend, and a third portion axially spaced from the second portion by a second axial U-shaped bend and extending circumferentially around the second circumferential portion of the interior surface of the flow passage.

Abstract: A flow sensing device includes a first body member defining an inlet port, an upstream sensor port, and a first connecting port; a second body member defining an outlet port, a downstream sensor port, and a second connecting port; a flow restricting element defining a flow restricting passage and including a first end connection coupled to the first connecting port and a second end connection coupled to the second connecting port, such that the flow restricting passage is disposed between the inlet port and the outlet port, and between the upstream sensor port and the downstream sensor port; a first fluid sensor assembled with the upstream sensor port; and a second fluid sensor assembled with the downstream sensor port.

Abstract: A nasal simulator includes a three-dimensional (3D) printed nasal cavity within based on diagnostic imagery of a human nasal cavity. The nasal simulator comprising a fan system positioned to mimic air flow through the human nasal cavity. A first probe access bore is formed through the 3D printed nasal cavity to a first location having a first internal contour. An anemometer insert having an outer diameter sized to be slidingly received in and to pneumatically seal the first probe access bore, the anemometer insert having a distal contour that aligns with the first internal contour of the 3D printed nasal cavity, the anemometer insert having a longitudinal bore that is sized to receive a probe of an anemometer to detect characteristics of the air flow through the 3D cavity.

Abstract: A fluid monitoring module includes a flow sensing device and a controller disposed in an enclosure. The flow sensing device includes a body including an inlet port, an outlet port, an upstream sensor port, a downstream sensor port, and a flow passage disposed between the inlet port and the outlet port, and between the upstream sensor port and the downstream sensor port. A first fluid sensor is assembled with the upstream sensor port, and a second fluid sensor is assembled with the downstream sensor port. The controller is in circuit communication with the first and second fluid sensors for receiving at least one of pressure indicating signals and temperature indicating signals from each of the first and second fluid sensors, and for measuring fluid data based on the received signals.

Abstract: A method of cooling a battery cell includes: atomizing a cooling fluid by driving it through a micro-nozzle at a pressure sufficient to create a jet of aerosolized liquid droplets while retaining sufficient momentum in flow of the fluid to travel from the nozzle to an outer surface of the battery cell; impinging the spray of the jet of aerosolized liquid droplets on an outer surface of the battery cell; partially evaporating the liquid droplets on the outer surface to conduct heat from the outer surface; and convecting heat from the outer surface of the battery via the cooling fluid.

Abstract: The combine system provides a motor driven paddle system for the movement of grain from combine storage, such as a hopper, to secondary storage, including but not limited to a grain bin, truck, or grain cart. The paddles are constructed from a somewhat rigid material that enable the paddles to move the grain to the secondary storage. The paddle conveyor may be partially enclosed by a housing that protects users from accidental contact with the paddles and the paddle conveyor.