Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.

Abstract: Techniques and devices are described for generating modified audio signals. The techniques include receiving an audio signal at a device, tracking a movement of the device, generating a first modified audio signal to spatialize the audio signal, generating a second modified audio signal to spatialize the audio signal, causing the first modified audio signal to be rendered using a first speaker of the device, and causing the second modified audio signal to be rendered using a second speaker of the device. In some cases, the first modified audio signal is generated using a first head-related transfer function (HRTF) and the movement of the device, and the second modified audio signal is generated using a second HRTF and the movement of the device, where the second HRTF is different from the first HRTF. Numerous variations and configurations will be apparent in view of this disclosure.

Abstract: A lockbolt swage end effector incorporates a swage tool releasably engaged by a connector assembly to hydraulic operator carried in a frame. A two piece core-bolt operably connects the swage tool and the hydraulic operator through the connector assembly. A connection flange attaches the frame to a mating flange on a robotic manipulator.

Abstract: Selecting user access policies for a new system, by collecting user, access policy, and resource metadata for a plurality of other users storing data dictated by one or more access restriction policies. The collected metadata is anonymized with respect to personal identifying information, and is stored in an anonymized analytics database. The system receives specific user, access policy and resource metadata for the new system from a specific user, and matches the received specific user metadata to the collected metadata to identify an optimum access policy of the one or more access policies based on the assets and access restriction requirements of the new system. The new system is then configured with the identified optimum access policy as an initial configuration.

Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.

Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.

Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.

Abstract: A surgical restraint is disclosed including a body strap, a sling, and a connecting strap. The body strap is arranged and disposed to wrap over patient's torso and around a support disposed below the patient, restraining the patient against the support. The sling is arranged and disposed to cradle an upper arm, an elbow and a forearm of a patient's arm. The connecting strap includes a first attachment site associated with a brace and a second attachment site associated with the sling. The connecting strap is arranged and disposed to cross over the patient's shoulder between the first attachment site and the second attachment site. The surgical restraint is arranged and disposed to restrain the patient's arm against the patient's torso and removed from a surgical site.

Abstract: Disclosed are compositions suitable for use as alternatives or substitutes for natural tobacco. Disclosed compositions include combustible products comprising leafy material from one or more plants classified in the brassicaceae or spinnacia plant family. Also disclosed are methods for the manufacture and use of the disclosed compositions.

Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.

Abstract: An access panel for a body of a vehicle is provided that includes a dome portion, a flat portion, and an extension portion. The dome portion has a reinforcing element. The extension portion extends from the flat portion. A floor panel structure for a vehicle is also provided that includes a metal sheet and an access panel. The metal sheet includes an aperture. The access panel includes a dome portion, a flat portion, and an extension portion. The access panel is coupled to the metal sheet over the aperture, and the flat portion and the extension portion are configured to transmit a downward force applied to the access panel to the metal sheet.

Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.

Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.

Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.

Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.

Abstract: Methods of using glucagon-like peptide 1 receptor (GLP1R) agonists are generally disclosed herein. In certain aspects, the disclosure provides methods of treating type 2 diabetes that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of treating obesity that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of lowering glycated hemoglobin (for example, lowering HbA1c) that include administering a GLP1R agonist according to certain dosage regimens. Compositions containing GLP1R agonists and their manufacture, for example, for use as a medicament are also disclosed herein.

Abstract: A rear support structure for a vehicle includes a parcel cross-member and a brace assembly. The parcel cross-member extends from a first side structure to a second side structure of the vehicle and includes a first vertical member, a second vertical member, and an upper horizontal member that at least partially define an opening between the cargo area and the passenger compartment. The brace assembly includes a first brace extending across the opening and including a first end secured to the upper horizontal member adjacent a longitudinal centerline of the vehicle and a second brace extending across the opening and including a first end secured to the upper horizontal member adjacent to the longitudinal centerline. The first brace further includes a second end secured to the first vertical member and the second brace includes a second end secured to the first vertical member.

Abstract: A rear support structure for a vehicle includes a parcel cross-member and a brace assembly. The parcel cross-member extends from a first side structure to a second side structure of the vehicle and includes a first vertical member, a second vertical member, and an upper horizontal member that at least partially define an opening between the cargo area and the passenger compartment. The brace assembly includes a first brace extending across the opening and including a first end secured to the upper horizontal member adjacent a longitudinal centerline of the vehicle and a second brace extending across the opening and including a first end secured to the upper horizontal member adjacent to the longitudinal centerline. The first brace further includes a second end secured to the first vertical member and the second brace includes a second end secured to the first vertical member.

Abstract: An access panel for a body of a vehicle is provided that includes a dome portion, a flat portion, and an extension portion. The dome portion has a reinforcing element. The extension portion extends from the flat portion. A floor panel structure for a vehicle is also provided that includes a metal sheet and an access panel. The metal sheet includes an aperture. The access panel includes a dome portion, a flat portion, and an extension portion. The access panel is coupled to the metal sheet over the aperture, and the flat portion and the extension portion are configured to transmit a downward force applied to the access panel to the metal sheet.

Abstract: Light modules for converting the wavelength of light are described herein along with methods for using and making such modules and devices incorporating such modules.