Patents by Inventor R. Kiplin Guy

R. Kiplin Guy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
    Patent number: 7696244
    Abstract: The invention provides compositions, including pharmaceutical preparations, which comprise one or more substituted thiophene, benzofuran, pyrimidinetrione, dihydropyridine, tetrahydrocarbazol or anthraquinone compounds. The invention also features methods of use of such compositions in increasing activity of mutant-cystic fibrosis transmembrane conductance regulator protein in a cell, e.g. by increasing ion transport in a mutant-CFTR.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: April 13, 2010
    Assignee: The Regents of the University of California
    Inventors: Alan Verkman, Luis J. V. Galietta, R. Kiplin Guy
  • Small molecule inhibition of a PDZ-domain interaction
    Patent number: 7601750
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: October 13, 2009
    Assignee: The Regents of the University of California
    Inventors: R. Kiplin Guy, Irwin D. Kuntz, Jose Haresco, Naoaki Fujii, Kathleen P. Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof
    Publication number: 20080319008
    Abstract: The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ?F508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 25, 2008
    Inventors: Alan Verkman, R.Kiplin Guy, Nicoletta Pedemonte, Luis J.V. Galietta
  • Small molecule inhibition of a PDZ-domain interaction
    Patent number: 7141600
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: November 28, 2006
    Assignee: The Regents of the University of California
    Inventors: R. Kiplin Guy, Irwin D. Kuntz, Jose Haresco, Naoaki Fujii, Kathleen P. Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David M. Jablons