Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: An ultrasound system includes a transducer array including a flexible substrate, ultrasound transducer elements disposed on the flexible substrate and configured to transmit and acquire ultrasound signals that propagate in a body of a patient, and strain sensors coupled to or integrated into the flexible substrate and configured to measure a strain in the flexible substrate generated by flexing the flexible substrate. The ultrasound system also includes a processor coupled to the ultrasound transducer elements and the strain sensors, wherein the processor is configured to process the signals acquired by the ultrasound transducer elements based at least in part on the strain measured by the strain sensors.

Abstract: In a method of determining and sharing proximity of device users within an environment of an observation platform, the observation platform determines that a first communication device associated with a first user is in the environment of the observation platform. The observation platform detects that the first communication device is in proximity to a second communication device associated with a second user. Responsive to the detection, the observation platform generates proximity information for the first user and the second user. The observation platform relays the proximity information to a second observation platform via a computer network, wherein a second environment of the second observation platform is separate from the environment of the observation platform.

Abstract: The innovation discloses systems, methods and computer program products that reduce complexity and associated measures that are taken to ensure trust in secured transactions as necessitated by requirements present only in an ecommerce environment that do not have a parallel with traditional bricks and mortar commercial transactions. The innovation enables a multitude of mobile wallet applications to engage and obtain services from ecommerce applications wherein backend processing by a mobile wallet server obtains and delivers funds to ecommerce applications without sharing a subset of sensitive data, associated with a mobile wallet application user for the secured transactions. The innovation further provides for a wallet network to be initiated and engaged in which the secured transactions can take place, adopting and adapting social network application connectivity.

Abstract: A method for validating a trained artificial intelligence (AI) model on a device is provided. The method includes deploying a validation model generated by applying a plurality of anticipated configurational changes associated with the trained AI model requiring validation. Further, the method includes providing input data to each of the validation model and the trained AI model for receiving an output from each of the validation model and the trained AI model, wherein the output of the validation model is further based on one or more actual configurational deviations that occurred during training of the trained AI model since deployment of the trained AI model on the device. Furthermore, the method includes combining the output of each of the validation model and the trained AI model to validate the trained AI model.

Abstract: A system includes a computing platform having a hardware processor and a memory storing software code, a memory data structure storing memory features for an artificial intelligence interactive character (AIIC), and a trained machine learning (ML) model. The software code is executed to elicit, using the AIIC, a reminiscence from a user, predict, using the trained ML model and the reminiscence, one or more user memory feature(s) of the reminiscence, identify, using the memory data structure, one or more of the memory features for the AIIC as corresponding to the user memory feature(s), and determine, using the user memory feature(s), a mood modifier for a creative composition. The software code is further executed to produce, based on the mood modifier and the corresponding one or more of the plurality of memory features for the AIIC, the creative composition, and provide the creative composition to the AIIC.

Abstract: A method of making a silicone gel adhesive is described comprising providing an acrylic polymer, the acrylic polymer comprising at least 50 wt.-% of polymerized units of C1-C32 (meth)acrylate ester monomer; providing at least one non-functional polydiorganosiloxane, hydroxy-functional polydiorganosiloxane, or a mixture thereof; combining the acrylic polymer and polydiorganosiloxane into a mixture; coating the mixture onto a substrate, and subjecting the mixture to radiation thereby crosslinking the mixture. Also described is a silicone gel adhesive comprising a crosslinked material at least one non-functional polydiorganosiloxane, hydroxy-functional polydiorganosiloxane, or a mixture thereof; and an acrylic polymer comprising at least 50 wt.-% of polymerized units of alkyl (meth)acrylate monomers and a gel content of at least 20 wt.-%.

Abstract: An exemplary trim assembly comprises an escutcheon, a drive spindle, a lock mechanism, a cam mechanism, and a driver. The drive spindle is mounted to the escutcheon for rotation about a longitudinal axis. The lock mechanism includes a lock gear movably mounted in the escutcheon. The cam mechanism includes a first cam defined by the escutcheon and a second cam defined by the lock gear. The driver is operable to rotate the lock gear between a first rotational position and a second rotational position. The cam mechanism is configured to longitudinally drive the lock gear from a first longitudinal position to a second longitudinal position as the lock gear rotates from the first rotational position to the second rotational position. Movement of the lock gear between the first longitudinal position and the second longitudinal position transitions the lock mechanism between a locked state and an unlocked state.

Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

Abstract: In a method of query derivation in an observation platform a signal from a first communication device is received at a second communication device that is associated with a computer system. The computer system is associated with an organization and a first characteristic of the signal corresponds to an audible source. The signal is parsed, by the computer system according to a policy, to determine metadata associated with the signal, wherein the first communication device is operated by a user and wherein the policy dictates rules for use of the metadata. The computer system determines a prior user history of the user. The computer system converts the audible source of the signal to text or machine understandable language. The computer system derives a query related to the organization based on at least one of the prior user history, the metadata, and the text or machine understandable language.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize, index, search, and present time series data based on searches. Time series data are sequences of time stamped records occurring in one or more usually continuous streams, representing some type of activity. In one embodiment, time series data is stored as discrete events time stamps. A search is received and relevant event information is retrieved based in whole or in part on the time stamp, a keyword indexing mechanism, or statistical indices calculated at the time of the search.

Abstract: Techniques are disclosed relating to memory error tracking and logging. In some embodiments, a memory cache controller circuitry is configured to track, using multiple circuit entries, numbers of detected correctable errors associated with multiple respective locations, and in response to detecting a threshold number of correctable errors for a particular location, generate a signal to the one or more processors that identifies the particular location. In some embodiments, the memory cache controller circuitry includes multiple circuit entries for tracking uncorrectable errors.

Abstract: Embodiments of systems, apparatuses and methods provide enhanced function as a service (FaaS) to users, e.g., computer developers and cloud service providers (CSPs). A computing system configured to provide such enhanced FaaS service include one or more controls architectural subsystems, software and orchestration subsystems, network and storage subsystems, and security subsystems. The computing system executes functions in response to events triggered by the users in an execution environment provided by the architectural subsystems, which represent an abstraction of execution management and shield the users from the burden of managing the execution. The software and orchestration subsystems allocate computing resources for the function execution by intelligently spinning up and down containers for function code with decreased instantiation latency and increased execution scalability while maintaining secured execution.

Abstract: Systems and methods for detecting compromised sensors using dynamic watermarking. In some examples, a method includes injecting a dynamic random signal into an input of a power distribution system. The power distribution system includes at least one sensor and at least one power electronic controller configured to use the at least one sensor. The method includes monitoring a sensor signal from the at least one sensor. The method includes determining whether the at least one sensor is compromised based on a comparison between the dynamic random signal and the sensor signal.

Abstract: The present disclosure relates to digital experience development platforms and, more particularly, one or more components, systems and methods thereof of an intelligent digital experience development platform (IDXDP) configured to assist different users in the development, design and deployment of digital applications. A computer-implemented method comprises: determining, by a computing device, that each of a plurality of users of an integrated development environment (IDE) has a common question about performing a task in the IDE; determining, by the computing device, that a community-accepted answer exists to the common question about performing the task in the IDE; and updating support documentation for the IDE based on the community-accepted answer to the common question about performing the task in the IDE.

Abstract: The present disclosure provides for devices, systems and methods for precise human head positioning in space. The present disclosure provides for control of precise human head positioning in space with use of drawing lines generated via a facial recognition computer software and positioning of sensors with permanent identification markings onto the human head according to those markings.

Abstract: The innovation discloses systems, methods and computer program products that reduce complexity and associated measures that are taken to ensure trust in secured transactions as necessitated by requirements present only in an ecommerce environment that do not have a parallel with traditional bricks and mortar commercial transactions. The innovation enables a multitude of mobile wallet applications to engage and obtain services from ecommerce applications wherein backend processing by a mobile wallet server obtains and delivers funds to ecommerce applications without sharing a subset of sensitive data, associated with a mobile wallet application user for the secured transactions. The innovation further provides for a wallet network to be initiated and engaged in which the secured transactions can take place, adopting and adapting social network application connectivity.

Abstract: The innovation discloses systems, methods and computer program products that reduce complexity and associated measures that are taken to ensure trust in secured transactions as necessitated by requirements present only in an ecommerce environment that do not have a parallel with traditional bricks and mortar commercial transactions. The innovation enables a multitude of mobile wallet applications to engage and obtain services from ecommerce applications wherein backend processing by a mobile wallet server obtains and delivers funds to ecommerce applications without sharing a subset of sensitive data, associated with a mobile wallet application user for the secured transactions.

Abstract: Techniques are disclosed relating to memory error tracking and logging. In some embodiments, a memory cache controller circuitry is configured to track, using multiple circuit entries, numbers of detected correctable errors associated with multiple respective locations, and in response to detecting a threshold number of correctable errors for a particular location, generate a signal to the one or more processors that identifies the particular location. In some embodiments, the memory cache controller circuitry includes multiple circuit entries for tracking uncorrectable errors.