Patents by Inventor Rémon Boer

Rémon Boer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS
    Publication number: 20160362715
    Abstract: The present invention relates to the preparation of ?-lactam antibodies comprising contacting 4-hydroxyphenylglycine of phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 15, 2016
    Inventors: Ulrike Maria MUELLER, Rémon BOER, Roelof Ary Lans BOVENBERG
  • MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS
    Publication number: 20140349340
    Abstract: The present invention relates to the preparation of ?-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation.
    Type: Application
    Filed: January 28, 2013
    Publication date: November 27, 2014
    Inventors: Ulrike Maria Mueller, Rémon Boer, Roelof Ary Lans Bovenberg
  • Production of ?-Lactam antibiotics
    Patent number: 8293511
    Abstract: The present invention describes a process for the production of an N-?-amino-hydroxyphenylacetyl or an N-?-aminophenylacetyl ?-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl ?-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: October 23, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Marcus Hans, Roelof Ary Lans Bovenberg, Paul Klaassen, Rémon Boer, Jan Metske Van Der Laan
  • PRODUCTION OF BETA-LACTAM ANTIBIOTICS
    Publication number: 20100009404
    Abstract: The present invention describes a process for the production of an N-?-amino-hydroxyphenylacetyl or an N-?-aminophenylacetyl ?-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl ?-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides.
    Type: Application
    Filed: October 2, 2007
    Publication date: January 14, 2010
    Inventors: Marcus Hans, Roelof Ary Lans Bovenberg, Paul Klaassen, Rémon Boer, Jan Metske Van Der Laan