Patents by Inventor R. Nagarajan

R. Nagarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8002987
    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: August 23, 2011
    Assignee: Postech Academy-Industry Foundation
    Inventors: Kimoon Kim, Kyeng-Min Park, Young-Ho Ko, Narayanan Selvapalam, Erumaipatty R Nagarajan
  • Patent number: 7850992
    Abstract: Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: December 14, 2010
    Assignees: Postech Academy-Industry Foundation, Postech Foundation
    Inventors: Kimoon Kim, II Ha Hwang, Woo Sung Jeon, Hee Joon Kim, Dongwoo Kim, Narayanan Selvapalam, Erumaipatty R. Nagarajan
  • Patent number: 7718128
    Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of f
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: May 18, 2010
    Assignee: Postech Foundation
    Inventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
  • Publication number: 20090095677
    Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of f
    Type: Application
    Filed: December 19, 2008
    Publication date: April 16, 2009
    Applicants: POSTECH FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Kimoon KIM, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
  • Patent number: 7479254
    Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of f
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: January 20, 2009
    Assignees: Postech Foundation, Postech Academy-Industry Foundation
    Inventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Iiha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
  • Publication number: 20080290028
    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
    Type: Application
    Filed: March 24, 2006
    Publication date: November 27, 2008
    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Kimoon Kim, Young-Ho Ko, Kyeng-Min Park, Narayanan Selvapalam, Erumaipatty R. Nagarajan
  • Patent number: 7420061
    Abstract: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: September 2, 2008
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James W. Malecha, Stephen Bertenshaw, Matthew J. Graneto, Jeffery S. Carter, Jinglin Li, Srinivasan R. Nagarajan, David L. Brown, Donald J. Rogier, Jr., Thomas D. Penning, Ish K. Khanna, Xiangdong Xu, Richard M. Weier
  • Publication number: 20070154553
    Abstract: Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
    Type: Application
    Filed: October 25, 2006
    Publication date: July 5, 2007
    Applicants: POSTECH FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Kimoon KIM, Il Ha HWANG, Woo Sung JEON, Hee Joon KIM, Dongwoo KIM, Narayanan SELVAPALAM, Erumaipatty R. NAGARAJAN
  • Publication number: 20040092538
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: December 20, 2002
    Publication date: May 13, 2004
    Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
  • Patent number: 6414180
    Abstract: The invention herein is directed to a process for the preparation of chiral &bgr;-amino acids and esters of the formula wherein X and Y are the same or different halo groups, R2 is H or lower alkyl and isomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: July 2, 2002
    Assignee: G. D. Searle
    Inventors: Pierre-Jean Colson, Alok K. Awasthi, Srinivasan R. Nagarajan
  • Patent number: 6034256
    Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: March 7, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan R Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz
  • Patent number: 6007679
    Abstract: The invention relates to a paper making process in which improved drainage and retention is obtained by the addition of an effective amount of a cationic dispersion polymer to an aqueous cellulosic paper making slurry prior to shearing the slurry; which cationic dispersion polymer is selected from a group of copolymers consisting of:i) a copolymer of about 10 mole % DMAEA.BCQ and about 90 mole % AcAm;ii) a copolymer of about 10 mole % DMAEA.MCQ and about 90 mole % AcAm; andiii) a copolymer of about 20 mole % DMAEA.MCQ and about 80 mole % AcAm; andadding to the slurry, after said cationic dispersion polymer is added and the slurry is sheared,a microparticle selected from the group consisting ofa) copolymers of acrylic acid and acrylamide;b) bentonite; andc) dispersed silica.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: December 28, 1999
    Assignee: Nalco Chemical Company
    Inventors: R. Nagarajan, Jane B. Wong Shing
  • Patent number: 5968970
    Abstract: Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.
    Type: Grant
    Filed: January 2, 1998
    Date of Patent: October 19, 1999
    Assignee: G. D. Searle & Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan R. Nagarajan, David L. Brown, Joseph J. McDonald
  • Patent number: 5446076
    Abstract: A method of stabilizing polymeric lattices comprising the addition of an organophilic clay which, when properly activated and dispersed, sets up a network that will suspend the polymer particles and retard the settling process is disclosed. The network is easily destroyed by the application of shear, but then reforms when shear is removed.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: August 29, 1995
    Assignee: Nalco Chemical Company
    Inventors: Anthony G. Sommese, R. Nagarajan
  • Patent number: 5438088
    Abstract: Hydrogenated castor oil stabilizes water-in-oil dispersions of water soluble vinyl addition polymers.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: August 1, 1995
    Assignee: Nalco Chemical Company
    Inventors: Anthony G. Sommese, R. Nagarajan