Patents by Inventor R. Nagarajan
R. Nagarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8002987Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.Type: GrantFiled: March 24, 2006Date of Patent: August 23, 2011Assignee: Postech Academy-Industry FoundationInventors: Kimoon Kim, Kyeng-Min Park, Young-Ho Ko, Narayanan Selvapalam, Erumaipatty R Nagarajan
-
Patent number: 7850992Abstract: Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.Type: GrantFiled: October 25, 2006Date of Patent: December 14, 2010Assignees: Postech Academy-Industry Foundation, Postech FoundationInventors: Kimoon Kim, II Ha Hwang, Woo Sung Jeon, Hee Joon Kim, Dongwoo Kim, Narayanan Selvapalam, Erumaipatty R. Nagarajan
-
Patent number: 7718128Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: GrantFiled: December 19, 2008Date of Patent: May 18, 2010Assignee: Postech FoundationInventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
-
Publication number: 20090095677Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: ApplicationFiled: December 19, 2008Publication date: April 16, 2009Applicants: POSTECH FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon KIM, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
-
Patent number: 7479254Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: GrantFiled: April 20, 2006Date of Patent: January 20, 2009Assignees: Postech Foundation, Postech Academy-Industry FoundationInventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Iiha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
-
Publication number: 20080290028Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.Type: ApplicationFiled: March 24, 2006Publication date: November 27, 2008Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon Kim, Young-Ho Ko, Kyeng-Min Park, Narayanan Selvapalam, Erumaipatty R. Nagarajan
-
Patent number: 7420061Abstract: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.Type: GrantFiled: September 13, 2004Date of Patent: September 2, 2008Assignee: Pharmacia CorporationInventors: John J. Talley, James W. Malecha, Stephen Bertenshaw, Matthew J. Graneto, Jeffery S. Carter, Jinglin Li, Srinivasan R. Nagarajan, David L. Brown, Donald J. Rogier, Jr., Thomas D. Penning, Ish K. Khanna, Xiangdong Xu, Richard M. Weier
-
Publication number: 20070154553Abstract: Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.Type: ApplicationFiled: October 25, 2006Publication date: July 5, 2007Applicants: POSTECH FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon KIM, Il Ha HWANG, Woo Sung JEON, Hee Joon KIM, Dongwoo KIM, Narayanan SELVAPALAM, Erumaipatty R. NAGARAJAN
-
Publication number: 20040092538Abstract: The present invention relates to a class of compounds represented by the Formula I 1Type: ApplicationFiled: December 20, 2002Publication date: May 13, 2004Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
-
Patent number: 6414180Abstract: The invention herein is directed to a process for the preparation of chiral &bgr;-amino acids and esters of the formula wherein X and Y are the same or different halo groups, R2 is H or lower alkyl and isomers and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 2, 1999Date of Patent: July 2, 2002Assignee: G. D. SearleInventors: Pierre-Jean Colson, Alok K. Awasthi, Srinivasan R. Nagarajan
-
Patent number: 6034256Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.Type: GrantFiled: April 17, 1998Date of Patent: March 7, 2000Assignee: G.D. Searle & Co.Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan R Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz
-
Patent number: 6007679Abstract: The invention relates to a paper making process in which improved drainage and retention is obtained by the addition of an effective amount of a cationic dispersion polymer to an aqueous cellulosic paper making slurry prior to shearing the slurry; which cationic dispersion polymer is selected from a group of copolymers consisting of:i) a copolymer of about 10 mole % DMAEA.BCQ and about 90 mole % AcAm;ii) a copolymer of about 10 mole % DMAEA.MCQ and about 90 mole % AcAm; andiii) a copolymer of about 20 mole % DMAEA.MCQ and about 80 mole % AcAm; andadding to the slurry, after said cationic dispersion polymer is added and the slurry is sheared,a microparticle selected from the group consisting ofa) copolymers of acrylic acid and acrylamide;b) bentonite; andc) dispersed silica.Type: GrantFiled: October 14, 1998Date of Patent: December 28, 1999Assignee: Nalco Chemical CompanyInventors: R. Nagarajan, Jane B. Wong Shing
-
Patent number: 5968970Abstract: Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.Type: GrantFiled: January 2, 1998Date of Patent: October 19, 1999Assignee: G. D. Searle & CompanyInventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan R. Nagarajan, David L. Brown, Joseph J. McDonald
-
Patent number: 5446076Abstract: A method of stabilizing polymeric lattices comprising the addition of an organophilic clay which, when properly activated and dispersed, sets up a network that will suspend the polymer particles and retard the settling process is disclosed. The network is easily destroyed by the application of shear, but then reforms when shear is removed.Type: GrantFiled: May 23, 1994Date of Patent: August 29, 1995Assignee: Nalco Chemical CompanyInventors: Anthony G. Sommese, R. Nagarajan
-
Patent number: 5438088Abstract: Hydrogenated castor oil stabilizes water-in-oil dispersions of water soluble vinyl addition polymers.Type: GrantFiled: March 3, 1994Date of Patent: August 1, 1995Assignee: Nalco Chemical CompanyInventors: Anthony G. Sommese, R. Nagarajan