Abstract: A steering shaft assembly includes a shaft having a first end region including a nose, a male spline region coupleable with a female spline region of a clamp yoke, a ring flag seat adjacent said nose, and a first ring flag locating feature between said ring flag seat and said male spline region. The steering shaft assembly also includes a ring flag having an annular band seated on said ring flag seat, a flag extending axially from said annular band in a first direction beyond said first end and radially outwardly from said annular band, and a second ring flag locating feature extending axially from said annular band in a second direction opposite said first direction, said second ring flag locating feature interacting with said first ring flag locating feature to orient said ring flag in a predetermined rotational orientation relative to said shaft.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: Systems and methods for manufacturing a composite member. The system and methods are configured to move different types of composite plies from different supply stations. The composite plies are moved along a conveyance member and then with a transfer station to a forming tool. One or more forming members form the composite plies onto the forming tool.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: According to various embodiments, an array of elements forms an artificially-structured material. The artificially-structured material can also include an array of tuning mechanisms included as part of the array of elements that are configured to change material properties of the artificially-structured material on a per-element basis. The tuning mechanisms can change the material properties of the artificially-structured material by changing operational properties of the elements in the array of elements on a per-element basis based on one or a combination of stimuli detected by sensors included in the array of tuning mechanisms, programmable circuit modules included as part of the array of tuning mechanisms, data stored at individual data stores included as part of the array of tuning mechanisms, and communications transmitted through interconnects included as part of the array of elements.

Abstract: An apparatus and method for a frequency based integrated circuit that selectively filters out unwanted bands or regions of interfering frequencies utilizing one or more tunable notch or bandpass filters or tunable low or high pass filters capable of operating across multiple frequencies and multiple bands in noisy RF environments. The tunable filters are fabricated within the same integrated circuit package as the associated frequency based circuitry, thus minimizing R, L, and C parasitic values, and also allowing residual and other parasitic impedance in the associated circuitry and IC package to be absorbed and compensated.

Abstract: Systems, methods, and apparatus are described for a locking folding knife having a handle lock and a safety switch arranged around and rotatable around a pivot axis of the knife. In an engaged position the switch overlaps at least a portion of the handle lock and prevents it from moving into an unlocked position. A spring, such as a wire form spring, can be arranged within a pocket of the switch, and when the switch is moved between engaged and disengaged positions the spring can be compressed generating a rotational bias on the switch urging the switch toward either the engaged or disengaged position.

Abstract: An apparatus and method for a frequency based integrated circuit that selectively filters out unwanted bands or regions of interfering frequencies utilizing one or more tunable notch or bandpass filters or tunable low or high pass filters capable of operating across multiple frequencies and multiple bands in noisy RF environments. The tunable filters are fabricated within the same integrated circuit package as the associated frequency based circuitry, thus minimizing R, L, and C parasitic values, and also allowing residual and other parasitic impedance in the associated circuitry and IC package to be absorbed and compensated.

Abstract: Systems and methods for manufacturing a composite member. The system and methods are configured to move different types of composite plies from different supply stations. The composite plies are moved along a conveyance member and then with a transfer station to a forming tool. One or more forming members form the composite plies onto the forming tool.

Abstract: This disclosure describes systems, methods, and apparatus for a locking folding knife having a handle lock and a safety switch arranged around and rotatable around a pivot axis of the knife. In an engaged position the switch overlaps at least a portion of the handle lock and prevents it from moving into an unlocked position. A spring, such as a wire form spring, can be arranged within a pocket of the switch, and when the switch is moved between engaged and disengaged positions the spring can be compressed generating a rotational bias on the switch urging the switch toward either the engaged or disengaged position.

Abstract: A combined exercise mat and massaging roller is an apparatus used to perform exercises, especially bodyweight floor-based exercises and mobility work. The apparatus is configured to connect and disconnect easily for conversion between an exercise surface and an acute-pressure-supplying roller device. The apparatus includes an exercise mat, a plurality of massaging protrusions, and a snapping mechanism. The exercise mat provides a clean and comfortable exercise surface for a variety of yoga or body weight exercises. The plurality of massaging protrusions relates to a set of features that extend from the exercise mat to provide stimulation to various muscle groups and tissue during rolling. The snapping mechanism is a series of interlocking fasteners that engage with each other to secure the apparatus into a rolling configuration and subsequently release to toggle back into a flat configuration. The configuration of these components allows the apparatus to provide an exercise surface and roller.

Abstract: This disclosure describes systems, methods, and apparatus for a locking folding knife having a handle lock and a safety switch arranged around and rotatable around a pivot axis of the knife. In an engaged position the switch overlaps at least a portion of the handle lock and prevents it from moving into an unlocked position. A spring, such as a wire form spring, can be arranged within a pocket of the switch, and when the switch is moved between engaged and disengaged positions the spring can be compressed generating a rotational bias on the switch urging the switch toward either the engaged or disengaged position.

Abstract: This disclosure describes systems, methods, and apparatus for a locking folding knife having a handle lock and a safety switch arranged around and rotatable around a pivot axis of the knife. In an engaged position the switch overlaps at least a portion of the handle lock and prevents it from moving into an unlocked position. A spring, such as a wire form spring, can be arranged within a pocket of the switch, and when the switch is moved between engaged and disengaged positions the spring can be compressed generating a rotational bias on the switch urging the switch toward either the engaged or disengaged position.

Abstract: An apparatus, system, and method for the secure attachment and restraint of a pipe end within a fitting is disclosed. The invention includes a mechanical restraint apparatus that is integral and monolithic with the flange of a bell of a spigot-and-bell joint architecture, along with one or more internally disposed grooves within the bell that receive a circumferential gasket, in order to maintain a seal about the pipe end when it is inserted into the bell. The inventive apparatus combines features of mechanical connections and push-on connections.

Abstract: A method and apparatus are provided for excluding ineffective Inter System Page (ISPAGE) attempts in a mobile switching center (MSC). The present invention involves determining a time difference between an arrival time of an ISPAGE message and a time of a last seen activity of a mobile communications device. The ISPAGE message is dropped if the time difference exceeds an optimum time cutoff value. Also, the present invention provides a technique for determining the optimal time cutoff value by determining the fraction of all ISPAGE messages that may be dropped, and the fraction of all ISPAGE messages that produce page respones that will be admitted as a function of the optimal cutoff time value.

Abstract: A narrowband radar arrangement having a radar transmitter and a radar receiver mounted above a targeted water surface to monitor and determine a sea state of the targeted water surface. Fixed frequency signals are transmitted by the transmitter and received by the receiver, via a direct path and via a forward scattered path off the targeted water surface. An interference pattern of interfering direct path signals and forward scattered signals is used to determine an instantaneous height of the water surface and also to determine the sea state of the targeted water surface.

Abstract: A broadband radar arrangement having a radar transmitter and a radar receiver mounted above a targeted water surface to monitor and determine a sea state of the targeted water surface. Spectrally spaced signals are transmitted by the transmitter and received by the receiver, via a direct path and via a forward scattered path off the targeted water surface. An interference pattern of interfering direct path signals and forward scattered signals is used to determine an instantaneous height of the water surface and also to determine the sea state of the targeted water surface.

Abstract: A writing instrument has a barrel, a flag dispenser partially inserted into the barrel, and a rotating or sliding cover that engages with and covers the flag dispenser. In different positions, the rotating or sliding cover enables various functions of the flag dispenser. For example, the cover may be moved into a position to enable withdrawal of tape flags by a user. The cover may also be configured to move into a position that covers and protects the tape flags. In refillable embodiments of the writing instrument, the cover may also be removed to enable a flip cover portion of the flag dispenser to be opened to provide access to a tape flag chamber.

Abstract: In one embodiment of a writing instrument with a tape flag dispenser, a writing instrument has a body portion, a writing tip, and a flag dispenser that can be attached to and detached from the body portion. The flag dispenser holds a supply of tape flags, such as a folded stack of tape flags, which can be removed through an opening in the dispenser. The flag dispenser can be, for example, a cap that covers the writing tip or an attachment that affixes to an end of the body portion. In another embodiment, a writing instrument has a body portion, a writing tip, a flag dispenser integrally incorporated into the body portion, a containing section housed in the flag dispenser, and an opening in the containing section through which tape flags can be issued.