Patents by Inventor Rabih O. Darouiche
Rabih O. Darouiche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9956319Abstract: The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.Type: GrantFiled: May 31, 2013Date of Patent: May 1, 2018Assignee: BAYLOR COLLEGE OF MEDICINEInventors: Mohammad David Mansouri, Rabih O. Darouiche
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Publication number: 20150165095Abstract: The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.Type: ApplicationFiled: May 31, 2013Publication date: June 18, 2015Inventors: Mohammad David Mansouri, Rabih O. Darouiche
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Patent number: 8062691Abstract: A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.Type: GrantFiled: July 10, 2002Date of Patent: November 22, 2011Assignee: Baylor College of MedicineInventors: Mohammad David Mansouri, Rabih O. Darouiche
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Patent number: 7790183Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.Type: GrantFiled: February 26, 2004Date of Patent: September 7, 2010Assignee: Baylor College of MedicineInventors: Rabih O. Darouiche, Richard Hull
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Patent number: 7452345Abstract: A multi-lumen endotracheal tube has means for coating an inside and an outside surface of the endotracheal tube with antimicrobial and antibiofilm agents; means for releasing antimicrobial and antibiofilm agents from the endotracheal tube; means for using electrical current to enhance the efficacy of the antimicrobial and antibiofilm agents; and means for using ultrasound energy to enhance the efficacy of the antimicrobial and antibiofilm agents. In another feature of the present invention, the multi-lumen tube further has an outer lumen, and a concentric inner lumen, and the outer lumen contains the means for coating, the means for releasing, the means for using electrical current, and the means for using ultrasound energy. In another feature of the present invention, the inside and outside surfaces have a surface coating to reduce the buildup of bacteria and biofilm on the surface.Type: GrantFiled: September 17, 2003Date of Patent: November 18, 2008Assignee: Baylor College of MedicineInventors: Rabih O. Darouiche, Randall A. Prince
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Patent number: 7238363Abstract: The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.Type: GrantFiled: March 31, 2005Date of Patent: July 3, 2007Assignee: Baylor College of MedicineInventors: Mohammad D. Mansouri, Rabih O. Darouiche
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Publication number: 20040166094Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.Type: ApplicationFiled: February 26, 2004Publication date: August 26, 2004Inventors: Rabih O. Darouiche, Richard Hull
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Publication number: 20040166102Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.Type: ApplicationFiled: February 26, 2004Publication date: August 26, 2004Inventors: Rabih O. Darouiche, Richard Hull
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Publication number: 20040116845Abstract: A multi-lumen endotracheal tube has means for coating an inside and an outside surface of the endotracheal tube with antimicrobial and antibiofilm agents; means for releasing antimicrobial and antibiofilm agents from the endotracheal tube; means for using electrical current to enhance the efficacy of the antimicrobial and antibiofilm agents; and means for using ultrasound energy to enhance the efficacy of the antimicrobial and antibiofilm agents. In another feature of the present invention, the multi-lumen tube further has an outer lumen, and a concentric inner lumen, and the outer lumen contains the means for coating, the means for releasing, the means for using electrical current, and the means for using ultrasound energy. In another feature of the present invention, the inside and outside surfaces have a surface coating to reduce the buildup of bacteria and biofilm on the surface.Type: ApplicationFiled: September 17, 2003Publication date: June 17, 2004Applicant: Baylor College of MedicineInventors: Rabih O. Darouiche, Randall A. Prince
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Patent number: 6719991Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.Type: GrantFiled: June 8, 2001Date of Patent: April 13, 2004Assignee: Baylor College of MedicineInventors: Rabih O. Darouiche, Richard Hull
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Publication number: 20030229401Abstract: A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.Type: ApplicationFiled: June 17, 2003Publication date: December 11, 2003Applicants: BAYLOR, Baylor College of MedicineInventors: Mohammad David Mansouri, Rabih O. Darouiche
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Patent number: 6589591Abstract: A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.Type: GrantFiled: July 10, 2001Date of Patent: July 8, 2003Assignee: Baylor College of MedicineInventors: Mohammad David Mansouri, Rabih O. Darouiche
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Patent number: 6558686Abstract: A medical device of metallic or non-metallic material coated with a combination of antiseptics and a method for coating such an implant with a combination of antiseptics is provided. Different combinations of antiseptics can be used for different types of medical devices depending on the spectrum of organisms that cause the infections related to each device. The combination of different antiseptics has a synergistic effect against certain bacteria and fungi. The combination of antiseptic can be applied to the surface of a metallic device by dissolving the combination of antiseptics and a polymeric sticking agent in an acid solution to form an antiseptic solution, and applying the antiseptic solution, in an effective concentration to inhibit the growth of bacterial and fungal organisms, to at least a portion of the surfaces of the medical device.Type: GrantFiled: November 8, 1995Date of Patent: May 6, 2003Assignee: Baylor College of MedicineInventor: Rabih O. Darouiche
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Publication number: 20030065292Abstract: Indwelling medical devices resistant to microbial colonization and other complications include devices having a coating on one or more surfaces comprising an effective amount or concentration of an oxygen liberating substance, such as ozone, and optionally, one or more other therapeutic agents. Devices may alternately include a sleeve or other means which allows one or more surfaces of the device to be flushed or insufflated periodically with ozone or another oxygen liberating substance.Type: ApplicationFiled: June 5, 2002Publication date: April 3, 2003Inventors: Rabih O. Darouiche, David C. Shannon
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Patent number: 6475434Abstract: A biofilm penetrating composition for coating medical devices for substantially preventing the growth or proliferation of biofilm embedded microorganisms on at least one surface of the medical device is disclosed. A biofilm penetrating composition solution for cleaning medical devices which is capable of substantially removing all of the biofilm embedded microorganisms from at least one surface of medical devices is also disclosed. The biofilm penetrating composition coating and solution include a biofilm penetrating agent and may also include a base material. Medical devices coated with the biofilm penetrating composition and methods for coating medical devices and methods for removing biofilm embedded microorganisms from at least one surface of the medical devices are also disclosed.Type: GrantFiled: December 6, 1999Date of Patent: November 5, 2002Assignee: Baylor College of MedicineInventor: Rabih O. Darouiche
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Publication number: 20020031601Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and flngal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.Type: ApplicationFiled: June 8, 2001Publication date: March 14, 2002Inventors: Rabih O. Darouiche, Richard Hull
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Patent number: 6162487Abstract: A medical device of metallic or non-metallic material coated with a combination of antiseptics and a method for coating such an implant with a combination of antiseptics is provided. Different combinations of antiseptics can be used for different types of medical devices depending on the spectrum of organisms that cause the infections related to each device. The combination of different antiseptics has a synergistic effect against certain bacteria and fungi. The combination of antiseptic can be applied to the surface of a metallic device by dissolving the combination of antiseptics and a polymeric sticking agent in an acid solution to form an antiseptic solution, and applying the antiseptic solution, in an effective concentration to inhibit the growth of bacterial and fungal organisms, to at least a portion of the surfaces of the medical device.Type: GrantFiled: March 27, 1997Date of Patent: December 19, 2000Assignee: Baylor College of MedicineInventor: Rabih O. Darouiche
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Patent number: 5902283Abstract: A non-metallic antimicrobial impregnated medical implant, such as a catheter, and a method for impregnating a non-metallic medical implant with an antimicrobial agent is provided. The method for making the impregnated implant comprises the steps of forming an antimicrobial composition of an effective concentration to inhibit the growth of organisms, such as staphylococci, other gram-positive bacteria, gram-negative bacilli and Candida and applying the antimicrobial composition to at least a portion of the medical implant under conditions where the antimicrobial composition permeates the material of the medical implant. The antimicrobial composition is formed by dissolving an antimicrobial agent in an organic solvent, adding a penetrating agent to the composition, and adding an alkalinizing agent to the composition. The antimicrobial composition is preferably heated to a temperature between about 30.degree. C. and 70.degree. C.Type: GrantFiled: March 26, 1997Date of Patent: May 11, 1999Assignees: Baylor College of Medicine Board of Regents, The University of Texas SystemInventors: Rabih O. Darouiche, Issam Raad
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Patent number: 5853745Abstract: A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant has one or more of its surfaces coated with an antimicrobial coating layer and a protective coating layer formed over the antimicrobial coating layer. The protective coating layer includes a durable coating layer composed of material such as collodion and nylon, and a resilient coating layer composed of material such as collodion. The coating layers are applied by applying an antimicrobial coating layer to at least a portion of the surfaces of the medical implant, applying a durable coating layer over the antimicrobial coating layer, and applying a resilient coating layer over the durable coating layer.Type: GrantFiled: March 26, 1997Date of Patent: December 29, 1998Assignee: Baylor College of MedicineInventor: Rabih O. Darouiche
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Patent number: 5756145Abstract: A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant has one or more of its surfaces coated with an antimicrobial coating layer and a protective coating layer formed over the antimicrobial coating layer. The protective coating layer includes a durable coating layer composed of material such as collodion and nylon, and a resilient coating layer composed of material such as collodion. The coating layers are applied by applying an antimicrobial coating layer to at least a portion of the surfaces of the medical implant, applying a durable coating layer over the antimicrobial coating layer, and applying a resilient coating layer over the durable coating layer.Type: GrantFiled: November 8, 1995Date of Patent: May 26, 1998Assignee: Baylor College of MedicineInventor: Rabih O. Darouiche