Patents by Inventor Rachel Eren

Rachel Eren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8580256
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: November 12, 2013
    Assignee: Yeda Reseach and Development Company Limited
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
  • Publication number: 20100330099
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 30, 2010
    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, JR., Sandra O'Connor
  • Patent number: 7785595
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: August 31, 2010
    Assignee: Yeda Research and Development Company Limited
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
  • Publication number: 20080152658
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Application
    Filed: April 18, 2005
    Publication date: June 26, 2008
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Sandra O'Connor
  • Patent number: 7241445
    Abstract: Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis C virus (HCV) E2 glycoprotein and capable of neutralizing HCV infection in vivo in an animal model, as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HCV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HCV E2 antibodies are transformed in vitro by Epstein-Barr virus and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HCV E2 glycoprotein.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: July 10, 2007
    Assignee: DRK-Blutspendedienst Baden-Wurttemberg
    Inventors: Bernhard Kubanek, Marcia Da Silva Cardoso, Karl Sifmoneit, Shlomo Dagan, Rachel Eren
  • Publication number: 20050260195
    Abstract: Disclosed is a pharmaceutical composition for the treatment or prevention of hepatitis B virus infection, comprising a 1:3 mixture of two fully human anti HBsAg monoclonal antibodies 19.79.5 and 17.1.41. Also disclosed are preferred modes of administration. The pharmaceutical composition can be given as a monotherapy or in combination with other anti viral agents.
    Type: Application
    Filed: February 14, 2005
    Publication date: November 24, 2005
    Applicant: XTL BIOPHARMACEUTICALS LTD.
    Inventors: Shlomo Dagan, Rachel Eren
  • Publication number: 20040071710
    Abstract: Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis C virus (HCV) E2 glycoprotein and capable of neutralizing HCV infection in vivo in an animal model, as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HCV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HCV E2 antibodies are transformed in vitro by Epstein-Barr virus and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HCV E2 glycoprotein.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 15, 2004
    Inventors: Bernard Kubanek, Marcia Da Silva Cardoso, Karl Sifmoneit, Shlomo Dagan, Rachel Eren