Patents by Inventor Rachel Shahinian

Rachel Shahinian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA polymerases with improved activity
    Patent number: 10597644
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: March 24, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • DNA POLYMERASES WITH IMPROVED ACTIVITY
    Publication number: 20170191044
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Application
    Filed: March 17, 2017
    Publication date: July 6, 2017
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • Methods for conducting primer extension using DNA polymerases with improved activity
    Patent number: 9637726
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 2, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Patent number: 9400235
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 26, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • DNA POLYMERASES AND RELATED METHODS
    Publication number: 20160024548
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.
    Type: Application
    Filed: July 27, 2015
    Publication date: January 28, 2016
    Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers, Joseph San Filippo, Rachel Shahinian
  • DNA POLYMERASES WITH IMPROVED ACTIVITY
    Publication number: 20150191708
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Application
    Filed: March 24, 2015
    Publication date: July 9, 2015
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • DNA polymerases with improved activity
    Patent number: 9017979
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: April 28, 2015
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES
    Publication number: 20140120547
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Application
    Filed: December 23, 2013
    Publication date: May 1, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Patent number: 8652775
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 18, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • DNA POLYMERASES WITH IMPROVED ACTIVITY
    Publication number: 20120258501
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Application
    Filed: April 10, 2012
    Publication date: October 11, 2012
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • DNA POLYMERASES AND RELATED METHODS
    Publication number: 20110294168
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.
    Type: Application
    Filed: April 15, 2011
    Publication date: December 1, 2011
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Thomas Myers, Joseph San Filippo, Rachel Shahinian
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Publication number: 20090081661
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Application
    Filed: March 28, 2008
    Publication date: March 26, 2009
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian