Patents by Inventor Rachid Skouta

Rachid Skouta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ferroptosis inducing compound, compositions comprising the same, and methods of inducing ferroptosis
    Patent number: 11932599
    Abstract: Provided is a compound according to Formula 1 wherein X, R, R1, R2, R3, and R4 are as defined herein. The compound of Formula 1 can be useful in a composition and in a method for inducing ferroptosis in a cell.
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: March 19, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Rachid Skouta, Thomas K. Dawson, Rohit Bhadoria
  • FERROPTOSIS INDUCING COMPOUND, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF INDUCING FERROPTOSIS
    Publication number: 20220324798
    Abstract: Provided is a compound according to Formula 1 wherein X, R, R1, R2, R3, and R4 are as defined herein. The compound of Formula 1 can be useful in a composition and in a method for inducing ferroptosis in a cell.
    Type: Application
    Filed: March 23, 2022
    Publication date: October 13, 2022
    Inventors: Rachid Skouta, Thomas K. Dawson, Rohit Bhadoria
  • Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
    Patent number: 11192849
    Abstract: The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Brent R. Stockwell, Rachid Skouta, Scott Dixon
  • Small molecule ferroptosis inducers
    Patent number: 10947188
    Abstract: The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 16, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Brent R. Stockwell, Kenichi Shimada, Rachid Skouta
  • Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
    Patent number: 10597381
    Abstract: The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 24, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta
  • SMALL MOLECULE FERROPTOSIS INDUCERS
    Publication number: 20190315681
    Abstract: The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 17, 2019
    Inventors: Brent R. Stockwell, Kenichi Shimada, Rachid Skouta
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
    Publication number: 20190292135
    Abstract: The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Application
    Filed: March 8, 2019
    Publication date: September 26, 2019
    Inventors: Brent R. Stockwell, Rachid Skouta, Scott Dixon
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
    Publication number: 20190135782
    Abstract: The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 9, 2019
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta
  • Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
    Patent number: 10259775
    Abstract: The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: April 16, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Brent R. Stockwell, Rachid Skouta, Scott Dixon
  • Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
    Patent number: 10233171
    Abstract: The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 19, 2019
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta
  • Antiparasitic compositions and methods utilizing substituted 5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridine derivatives
    Patent number: 9988395
    Abstract: The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula: where X, R1, R2, R3, R4, R5, and R6 are defined more fully below.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: June 5, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Rachid Skouta, Rosa A. Maldonado
  • ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED 5,5,7,7-TETRAMETHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE DERIVATIVES
    Publication number: 20170349606
    Abstract: The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula: where X, R1, R2, R3, R4, R5, and R6 are defined more fully below.
    Type: Application
    Filed: June 14, 2017
    Publication date: December 7, 2017
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Rachid Skouta, Rosa A. Maldonado
  • PHARMACEUTICAL COMPOSITIONS DIRECTLY TARGETING FKBP52 FOR THE TREATMENT OF PROSTATE CANCER AND METHODS OF USING SAME
    Publication number: 20170231964
    Abstract: Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.
    Type: Application
    Filed: August 20, 2015
    Publication date: August 17, 2017
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEM
    Inventors: Marc COX, Rachid SKOUTA, Artem CHERKASOV
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
    Publication number: 20170233370
    Abstract: The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Application
    Filed: February 24, 2017
    Publication date: August 17, 2017
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta
  • Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
    Patent number: 9580398
    Abstract: The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: February 28, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta
  • Antiparasitic Compositions and Methods Utilizing Substituted 5,5,7,7-Tetramethyl- 4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine Derivatives
    Publication number: 20160362420
    Abstract: The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula: where X, R1, R2, R3, R4, R5, and R6 are defined more fully below.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Rachid Skouta, Rosa A. Maldonado
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
    Publication number: 20160297748
    Abstract: The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Application
    Filed: December 1, 2014
    Publication date: October 13, 2016
    Inventors: Brent R. Stockwell, Rachid Skouta, Scott Dixon
  • Compounds, Compositions, and Methods For Modulating Ferroptosis and Treating Excitotoxic Disorders
    Publication number: 20150079035
    Abstract: The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 19, 2015
    Inventors: Brent R. Stockwell, Scott J. Dixon, Rachid Skouta