Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.

Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.

Abstract: Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device.

Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.

Abstract: The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants.

Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.

Abstract: The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants.

Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.

Abstract: The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and/or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device.

Abstract: Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.

Abstract: The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling.

Abstract: A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. The balloon portion is inflated to cause the sheath to rupture and release the self-expanding medical device. A number of radio-opaque markers in a pattern that will aid in determining whether or not the sheath has properly ruptured upon inflation of the balloon portion are provided on the sheath. The radio-opaque markers are positioned with respect to an expected sheath rupture propagation path along which the sheath is expected to rupture. The pattern of the markers changes as the sheath ruptures and this change is detected by an operator of the system.

Abstract: In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well with that specimen. Each well is configured to receive a sample material therein in contact with the specimen. A method includes disposing a specimen within a recessed portion of a test apparatus and coupling a top plate of the test apparatus to a base of the test apparatus such that a sealing engagement is formed between the top plate and the specimen. The top plate defines a plurality of apertures, each of at least two of the apertures collectively with the specimen defines a well. A sample material can be disposed within at least one well.