Patents by Inventor Radleigh G. SANTOS

Radleigh G. SANTOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective small molecule peptidomimetic melanocortin ligands
    Patent number: 11932628
    Abstract: The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: March 19, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Marcello A. Giulianotti, Clemencia Pinilla, Radleigh G. Santos, Richard A. Houghten
  • MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF
    Publication number: 20240002438
    Abstract: Certain embodiments of the invention provide a compound of formula (I) or a compound of formula (II): R1—A1—A2—A3—A4—N(R2)2 ??(I) R3—A5—A6—A7—A8—N(R4)2 ??(II) or a salt thereof, wherein R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, and A8 are as defined herein, as well as methods of use thereof.
    Type: Application
    Filed: September 14, 2022
    Publication date: January 4, 2024
    Inventors: Carrie Haskell-Luevano, Mark David Ericson, Richard A. Houghten, Clemencia Pinilla, Marcello Angelo Giulianotti, Radleigh G. Santos
  • SELECTIVE SMALL MOLECULE PEPTIDOMIMETIC MELANOCORTIN LIGANDS
    Publication number: 20220213068
    Abstract: The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: January 3, 2022
    Publication date: July 7, 2022
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Marcello A. Giulianotti, Clemencia Pinilla, Radleigh G. Santos, Richard A. Houghten
  • Polyamine compounds targeting the efflux pumps of multi-drug resistant bacterial pathogens and methods of using the same
    Patent number: 11117856
    Abstract: Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: September 14, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Renee Fleeman, Radleigh G. Santos, Marcello Angelo Giulianotti, Lindsey Shaw
  • Melanocortin ligands and methods of use thereof
    Patent number: 10899793
    Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(?O)—W—X—Y—Z—N(R2)2??(I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: January 26, 2021
    Assignees: Regents of the University of Minnesota, Torrey Pines Institute for Molecular Studies
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Jon R. Appel, Marc A. Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh G. Santos
  • POLYAMINE COMPOUNDS TARGETING THE EFFLUX PUMPS OF MULTI-DRUG RESISTANT BACTERIAL PATHOGENS AND METHODS OF USING THE SAME
    Publication number: 20190256452
    Abstract: Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 22, 2019
    Inventors: Renee Fleeman, Radleigh G. Santos, Marcello Angelo Giulianotti, Lindsey Shaw
  • Bis-cyclic guanidine compound compositions, methods of use and treatment thereof
    Patent number: 10052309
    Abstract: The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: August 21, 2018
    Assignees: University of South Florida, Torrey Pines Institute for Molecular Studies
    Inventors: Lindsey Neil Shaw, Renee Marie Fleeman, Richard Allen Houghten, Marcello Angelo Giulianotti, Radleigh G. Santos, Adel Nefzi
  • BIS-CYCLIC GUANIDINE COMPOUND COMPOSITIONS, METHODS OF USE AND TREATMENT THEREOF
    Publication number: 20180036286
    Abstract: The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: August 31, 2017
    Publication date: February 8, 2018
    Inventors: Lindsey Neil Shaw, Renee Marie Fleeman, Richard Allen Houghten, Marcello Angelo Giulianotti, Radleigh G. Santos, Adel Nefzi
  • MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF
    Publication number: 20170342107
    Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(?O)—W—X—Y—Z—N(R2)2 ??(I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
    Type: Application
    Filed: May 25, 2017
    Publication date: November 30, 2017
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Jon R. Appel, Marc A. Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh G. Santos
  • BIS-cyclic guanidine compound compositions, methods of use and treatment thereof
    Patent number: 9782388
    Abstract: The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: October 10, 2017
    Assignees: University of South Florida, Torrey Pines Institute for Molecular Studies
    Inventors: Lindsey Neil Shaw, Renee Marie Fleeman, Richard Allen Houghten, Marcello Angelo Giulianotti, Radleigh G. Santos, Adel Nefzi
  • BIS-CYCLIC GUANIDINE COMPOUND COMPOSITIONS, METHODS OF USE AND TREATMENT THEREOF
    Publication number: 20170065564
    Abstract: The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: February 19, 2015
    Publication date: March 9, 2017
    Inventors: Lindsey Neil SHAW, Renee Marie FLEEMAN, Richard Allen HOUGHTEN, Marcello Angelo GIULIANOTTI, Radleigh G. SANTOS, Adel NEFZI