Patents by Inventor Rafael Herrmann
Rafael Herrmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190271004Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).Type: ApplicationFiled: May 14, 2019Publication date: September 5, 2019Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET RICE
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Publication number: 20190233345Abstract: The disclosure relates to systems, compositions and methods for providing nutrients, fertilizers, crop protection agents and other crop inputs for a plant. The disclosure also relates to methods for increasing the uptake of a crop active compound into a growing plant.Type: ApplicationFiled: March 22, 2017Publication date: August 1, 2019Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: MARIOS AVGOUSTI, ROBERT RAY BURCH, TIMOTHY CASPAR, JASON DEBRUIN, JOHN D. EVERARD, RAJEEV L. GOROWARA, DARREN B. GRUIS, RAFAEL HERRMANN, SHANE FRANCIS KENDRA, KATRINA KRATZ, JACY CAMERON MACCHIA, RYAN ARTHUR PAPE, JEFFREY R. SCHUSSLER, NING WANG, JIHUA ZHANG
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Publication number: 20180030472Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.Type: ApplicationFiled: October 11, 2017Publication date: February 1, 2018Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: KAREN E. BROGLIE, DAVID CHARLES CERF, RAFAEL HERRMANN, ALBERT L. LU, BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL
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Patent number: 9816105Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.Type: GrantFiled: October 28, 2014Date of Patent: November 14, 2017Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: Karen E. Broglie, David Charles Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James Kevin Presnail
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Publication number: 20170175133Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).Type: ApplicationFiled: March 1, 2017Publication date: June 22, 2017Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET A. RICE
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Patent number: 9617559Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.Type: GrantFiled: September 30, 2014Date of Patent: April 11, 2017Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Edward Nelson, James Kevin Presnail, Janet A. Rice
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Publication number: 20150052643Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.Type: ApplicationFiled: October 28, 2014Publication date: February 19, 2015Inventors: KAREN E. BROGLIE, DAVID CHARLES CERF, RAFAEL HERRMANN, ALBERT L. LU, BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL
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Publication number: 20150025124Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET A. RICE
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Publication number: 20140343131Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus.Type: ApplicationFiled: August 8, 2014Publication date: November 20, 2014Inventors: RAFAEL HERRMANN, Michael Lassner, Albert Laurence Lu, Mark Edward Nelson, James Kevin Presnail, Janet Ann Rice
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Patent number: 8872001Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.Type: GrantFiled: June 3, 2011Date of Patent: October 28, 2014Assignee: Pioneer Hi Bred International IncInventors: Karen E. Broglie, David C. Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James K. Presnail
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Patent number: 8847013Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Lepidopteran pest, decreases the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest, thereby limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides as set forth, or active variants and fragments thereof, wherein a decrease in expression of one or more sequences in the target pest has insecticidal activity. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In a specific embodiment, the pest is Spodoptera frugiperda. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.Type: GrantFiled: January 9, 2009Date of Patent: September 30, 2014Assignees: Pioneer Hi Bred International Inc, E I du Pont de Nemours and CompanyInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Nelson, James K. Presnail, Janet A. Rice
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Patent number: 8809625Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, is capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.Type: GrantFiled: January 9, 2009Date of Patent: August 19, 2014Assignees: Pioneer Hi-Bred International, Inc., E.I. Du Pont de Nemours and CompanyInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark E. Nelson, James K. Presnail, Janet A. Rice
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Patent number: 8710296Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: GrantFiled: March 29, 2011Date of Patent: April 29, 2014Assignee: Pioneer Hi Bred International IncInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
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Patent number: 8367895Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. Target polynucleotides for specific protein classes and target polynucleotides set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof are provided, wherein a decrease in expression of one or more sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant part, bacteria and host cells comprising the silencing elements or an active variant or fragment thereof are also provided.Type: GrantFiled: January 9, 2009Date of Patent: February 5, 2013Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Nelson, James K. Presnail, Janet A. Rice
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Patent number: 8148510Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: GrantFiled: June 8, 2010Date of Patent: April 3, 2012Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company, The Regents of the University of CaliforniaInventors: Daniel J. Altier, Glen Dahlbacka, Irina Ellanskaya, Natalia Ellanskaya, legal representative, Rafael Herrmann, Jennie Hunter-Cevera, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Publication number: 20110301223Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.Type: ApplicationFiled: June 3, 2011Publication date: December 8, 2011Applicants: E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Karen E. Broglie, David C. Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James K. Presnail
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Patent number: 8071736Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: GrantFiled: July 30, 2009Date of Patent: December 6, 2011Assignees: Pioneer Hi-Bred International, Inc., E.I. Dupont de Nemours and CompanyInventors: Andre R. Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu
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Patent number: 8026415Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: GrantFiled: June 3, 2008Date of Patent: September 27, 2011Assignees: Pioneer Hi-Bred International, Inc., E.I. DuPont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
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Publication number: 20110179522Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: March 29, 2011Publication date: July 21, 2011Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
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Patent number: 7923599Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: GrantFiled: August 3, 2007Date of Patent: April 12, 2011Assignee: Pioneer Hi-Bred International, Inc.Inventors: Daniel J. Altier, Glen Dahlbacka, Irina Elleskaya, Natalia Ellanskaya, legal representative, Rafael Herrmann, Jennie Hunter-Cevera, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani