Patents by Inventor Rafael Herrmann

Rafael Herrmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190271004
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).
    Type: Application
    Filed: May 14, 2019
    Publication date: September 5, 2019
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET RICE
  • Publication number: 20190233345
    Abstract: The disclosure relates to systems, compositions and methods for providing nutrients, fertilizers, crop protection agents and other crop inputs for a plant. The disclosure also relates to methods for increasing the uptake of a crop active compound into a growing plant.
    Type: Application
    Filed: March 22, 2017
    Publication date: August 1, 2019
    Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARIOS AVGOUSTI, ROBERT RAY BURCH, TIMOTHY CASPAR, JASON DEBRUIN, JOHN D. EVERARD, RAJEEV L. GOROWARA, DARREN B. GRUIS, RAFAEL HERRMANN, SHANE FRANCIS KENDRA, KATRINA KRATZ, JACY CAMERON MACCHIA, RYAN ARTHUR PAPE, JEFFREY R. SCHUSSLER, NING WANG, JIHUA ZHANG
  • Publication number: 20180030472
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 1, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: KAREN E. BROGLIE, DAVID CHARLES CERF, RAFAEL HERRMANN, ALBERT L. LU, BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL
  • Patent number: 9816105
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: November 14, 2017
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Karen E. Broglie, David Charles Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James Kevin Presnail
  • Publication number: 20170175133
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).
    Type: Application
    Filed: March 1, 2017
    Publication date: June 22, 2017
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET A. RICE
  • Patent number: 9617559
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: April 11, 2017
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Edward Nelson, James Kevin Presnail, Janet A. Rice
  • Publication number: 20150052643
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Application
    Filed: October 28, 2014
    Publication date: February 19, 2015
    Inventors: KAREN E. BROGLIE, DAVID CHARLES CERF, RAFAEL HERRMANN, ALBERT L. LU, BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL
  • Publication number: 20150025124
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET A. RICE
  • Publication number: 20140343131
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 20, 2014
    Inventors: RAFAEL HERRMANN, Michael Lassner, Albert Laurence Lu, Mark Edward Nelson, James Kevin Presnail, Janet Ann Rice
  • Patent number: 8872001
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 28, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Karen E. Broglie, David C. Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James K. Presnail
  • Patent number: 8847013
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Lepidopteran pest, decreases the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest, thereby limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides as set forth, or active variants and fragments thereof, wherein a decrease in expression of one or more sequences in the target pest has insecticidal activity. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In a specific embodiment, the pest is Spodoptera frugiperda. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 30, 2014
    Assignees: Pioneer Hi Bred International Inc, E I du Pont de Nemours and Company
    Inventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Nelson, James K. Presnail, Janet A. Rice
  • Patent number: 8809625
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, is capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: August 19, 2014
    Assignees: Pioneer Hi-Bred International, Inc., E.I. Du Pont de Nemours and Company
    Inventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark E. Nelson, James K. Presnail, Janet A. Rice
  • Patent number: 8710296
    Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: April 29, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
  • Patent number: 8367895
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. Target polynucleotides for specific protein classes and target polynucleotides set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof are provided, wherein a decrease in expression of one or more sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant part, bacteria and host cells comprising the silencing elements or an active variant or fragment thereof are also provided.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: February 5, 2013
    Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company
    Inventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Nelson, James K. Presnail, Janet A. Rice
  • Patent number: 8148510
    Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: April 3, 2012
    Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company, The Regents of the University of California
    Inventors: Daniel J. Altier, Glen Dahlbacka, Irina Ellanskaya, Natalia Ellanskaya, legal representative, Rafael Herrmann, Jennie Hunter-Cevera, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
  • Publication number: 20110301223
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 8, 2011
    Applicants: E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Karen E. Broglie, David C. Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James K. Presnail
  • Patent number: 8071736
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: December 6, 2011
    Assignees: Pioneer Hi-Bred International, Inc., E.I. Dupont de Nemours and Company
    Inventors: Andre R. Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu
  • Patent number: 8026415
    Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: September 27, 2011
    Assignees: Pioneer Hi-Bred International, Inc., E.I. DuPont de Nemours and Company
    Inventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
  • Publication number: 20110179522
    Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Application
    Filed: March 29, 2011
    Publication date: July 21, 2011
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company
    Inventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
  • Patent number: 7923599
    Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: April 12, 2011
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Daniel J. Altier, Glen Dahlbacka, Irina Elleskaya, Natalia Ellanskaya, legal representative, Rafael Herrmann, Jennie Hunter-Cevera, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani