Patents by Inventor Rafael Victor Andino
Rafael Victor Andino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9956114Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.Type: GrantFiled: December 19, 2016Date of Patent: May 1, 2018Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Christopher John Brooks, Vladimir Zarnitsyn, Harrison J. White
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Patent number: 9937075Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: September 25, 2017Date of Patent: April 10, 2018Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20180042765Abstract: The present invention relates to a methods and devices for treating uveitis, macular edema associated with uveitis and macular edema associated with retinal vein occlusion in a human subject in need thereof. In certain aspects, devices provided herein include a medicament container defining a lumen configured to contain a medicament, a distal end portion of the medicament container including a coupling portion configured to be removably coupled to a needle assembly, a proximal end portion of the medicament container including a flange and a longitudinal shoulder; a piston assembly including a distal end portion movably disposed within the lumen of the medicament container; and a handle coupled to a proximal end portion of the piston assembly.Type: ApplicationFiled: June 17, 2015Publication date: February 15, 2018Inventors: Glenn NORONHA, Christopher John BROOKS, Rafael Victor ANDINO, Samirkumar PATEL, Daniel WHITE
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Publication number: 20180028358Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: September 25, 2017Publication date: February 1, 2018Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Patent number: 9770361Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: March 29, 2017Date of Patent: September 26, 2017Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20170224534Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: March 29, 2017Publication date: August 10, 2017Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20170224435Abstract: An apparatus includes a first tray member, a second tray member, and a lid. The first tray member has a first portion and a second portion. The first portion defines a first volume, and the second portion defines a second volume configured to receive a medicament container. The second tray member defines a third volume having a sidewall including a retention portion configured to retain an ocular injector within the third volume. The second tray member is coupled within first volume such that the sidewall of the second tray member and a sidewall of the first tray member enclose the ocular injector. The lid is coupled to the first tray member about the first volume, and is constructed from a material formulated to maintain sterility of the first volume.Type: ApplicationFiled: February 8, 2017Publication date: August 10, 2017Applicant: Clearside Biomedical, Inc.Inventors: Thomas Edward GODFREY, Rafael Victor ANDINO, Shelley Eckert HANCOCK, Keleigh Jo STRUDTHOFF
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Patent number: 9636253Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: January 5, 2017Date of Patent: May 2, 2017Assignee: Clearside Biomedical, inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20170112665Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: January 5, 2017Publication date: April 27, 2017Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20170095369Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Christopher John BROOKS, Vladimir ZARNITSYN, Harrison J. WHITE
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Patent number: 9539139Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: May 2, 2014Date of Patent: January 10, 2017Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20160106584Abstract: A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.Type: ApplicationFiled: May 30, 2014Publication date: April 21, 2016Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Samirkumar R. PATEL, Vladimir ZARNITSYN, Christopher John BROOKS
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Patent number: 9248614Abstract: The present invention provides methods for lathing at room temperature a silicone hydrogel material, in particular silicone hydrogel material having a high oxygen permeability and made of a polymerizable composition containing a relative large amount of oxyperm component, into contact lenses.Type: GrantFiled: June 8, 2005Date of Patent: February 2, 2016Assignee: Novartis AGInventors: John Christopher Phelan, Michael Hugh Quinn, Rafael Victor Andino, Marcia Kay Ash, Allen Douglas Gilliard, Tomasz Jankiewicz, Courtney Flem Morgan, Joseph Michael Lindacher, Corneliu Daniel Niculas
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Patent number: 9180047Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: October 24, 2014Date of Patent: November 10, 2015Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Christopher John Brooks, Jesse Yoo
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Publication number: 20150051581Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: October 24, 2014Publication date: February 19, 2015Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Christopher John BROOKS, Jesse YOO
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Publication number: 20150038905Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: May 2, 2014Publication date: February 5, 2015Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Christopher John BROOKS
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Patent number: 8454862Abstract: This invention is related to lenses and the associated processes used to manufacture lenses. In particular, the present invention is related to a process for designing and creating bifocal, multifocal, and single vision ophthalmic lenses by modulating an energy source.Type: GrantFiled: October 19, 2005Date of Patent: June 4, 2013Assignee: Novartis AGInventors: Rafael Victor Andino, Angelika Maria Domschke, Joseph Michael Lindacher, Courtney Flem Morgan
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Patent number: 7860594Abstract: The present invention provides a method for making an ophthalmic device. In particular, the present invention provides a method for production of a contact lens by means of stereolithography. A preferred stereolithography technique is based on polymerization and solidification of a contact lens forming liquid material by actinic irradiation one layer at a time. In addition, the present invention provides systems and methods for making a contact lens for a specific patient based on the prescription.Type: GrantFiled: April 17, 2007Date of Patent: December 28, 2010Assignee: Novartis AGInventors: Rafael Victor Andino, Robert Scott Meece, David Rosen, Benay Sager
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Patent number: 7780293Abstract: The present invention provides a method for designing and making a customized ophthalmic lens, such as a contact lens or an intraocular lens, capable of correcting high-order aberrations of an eye. The posterior surface of the customized contact lens is designed to accommodate the corneal topography of an eye. The design of the customized ophthalmic lens is evaluated and optimized in an optimizing routine using a computational model eye that reproduces the aberrations and corneal topography of an eye. The present invention also provides a system and method for characterizing the optical metrology of a customized ophthalmic lens that is designed to correct aberrations of an eye. Furthermore, the present invention provides a business model and method for placing an order for a pair of customized ophthalmic lenses.Type: GrantFiled: August 16, 2006Date of Patent: August 24, 2010Assignee: Novartis AGInventors: Rafael Victor Andino, Courtney Flem Morgan, Joseph Michael Lindacher
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Patent number: D750223Type: GrantFiled: October 14, 2014Date of Patent: February 23, 2016Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Christopher John Brooks